DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Magi and WWP1

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_008944.1	Gene:	WWP1 / 11059	HGNCID:	17004	Length:	922	Species:	Homo sapiens

Alignment Length:	331	Identity:	82/331 - (24%)
Similarity:	125/331 - (37%)	Gaps:	85/331 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 NCSRD---NVDDGGDA----GEMAA-ASQTLSSAGTDVVGNGSGH-GNGTVTGNG----EKSGGL 163
            |||..   .:.:.|||    ||.:| .:..|:..||:.:.|   | ...|:..|.    ..:|..
Human   151 NCSSSPTIEIQENGDALHENGEPSARTTARLAVEGTNGIDN---HVPTSTLVQNSCCSYVVNGDN 212

  Fly   164 AP--PGGHHLRPPPPPALKKSAS-----AVIGNSAS--REDVASLSGTSSLNSQMSVHNQFISGL 219
            .|  |.....||...||.|..||     .|.|.|:|  ..|.||::||..::.:
Human   213 TPSSPSQVAARPKNTPAPKPLASEPADDTVNGESSSFAPTDNASVTGTPVVSEE----------- 266

  Fly   220 PSNGIGSNGVHGGAATGRGGPPNSILKGSKEN----------------LLQNTYYNG------ET 262
              |.:..|..   :.|....|...||..|:.|                :|:....|.      |.
Human   267 --NALSPNCT---STTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEA 326

  Fly   263 GDSSLGSECGVGDVQHQNHESHDDPGDGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRLSK 327
            ..|.....| :..|:.|:..::.:      .||..||......|..|::||||.|:.|..|:
Human   327 AKSRQPDGC-MDPVRQQSGNANTE------TLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQ--- 381

  Fly   328 YQKKSLEDCCEDELPYGWEKIEDSMYGMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQ 392
                        .||.|||:..|....:|::||..|.|.::.|.:|:.|...:...|:.|:|...
Human   382 ------------PLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAM 434

  Fly   393 QQMQEQ 398
            ||..::
Human   435 QQFNQR 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	12/28 (43%)
		WW	342..372	CDD:238122	11/29 (38%)
		PDZ	443..534	CDD:214570
		DegQ	<455..534	CDD:223343
		PDZ_signaling	606..668	CDD:238492
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
WWP1	NP_008944.1	C2_E3_ubiquitin_ligase	17..140	CDD:175988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	210..388		50/215 (23%)
		HUL4	<307..922	CDD:227354	39/156 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900