DRSC/TRiP Functional Genomics Resources

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Protein Alignment Magi and Wwp1

DIOPT Version :9

Sequence 1:NP_001286661.1 Gene:Magi / 37403 FlyBaseID:FBgn0034590 Length:1202 Species:Drosophila melanogaster
Sequence 2:NP_796301.2 Gene:Wwp1 / 107568 MGIID:1861728 Length:918 Species:Mus musculus


Alignment Length:362 Identity:85/362 - (23%)
Similarity:120/362 - (33%) Gaps:146/362 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 PQQLA--PLNASHQHQHSHPHPHPHPVAAATSFATFNGNSNLNSSLANGSSRKFNCSRDNVDDGG 122
            |.|:|  |.||          |.|.||.:|.:..|.||.|  :|.||:.:|              
Mouse   217 PSQVAARPKNA----------PAPKPVTSAPTSDTVNGES--SSVLADNTS-------------- 255

  Fly   123 DAGEMAAASQTLSSAGTDVVGNGSGHGNGTVTGNGEKSGGLAPPGGHHLRPP--PPPALKK---- 181
            ..|.:..:..|.|::            |.|.|...|              ||  .|||..:    
Mouse   256 TMGTLLPSEDTTSTS------------NCTSTTTQE--------------PPVQEPPASSEHSEC 294

  Fly   182 --SASAVIGNSA-SREDVASLSGTSSLNSQM------------SVHNQFISGLPSNGIGSNGVHG 231
              ||||.:|..| |..|..|.|..:|:..::            ...|.....|||........||
Mouse   295 IPSASAEVGPEARSLIDPDSDSRNNSVFDKVRQPEGCVEPLRPQSGNTNTEALPSGWEQRKDPHG 359

  Fly   232 GAATGRGGPPNSILKGSKENLLQNTYYNGETGDSSLGSECGVGDVQHQNHESHDDPGDGLGPLPP 296
                                   .|||                    .:|.:.....:...||||
Mouse   360 -----------------------RTYY--------------------VDHNTRTTTWERPQPLPP 381

  Fly   297 KWETAYTERGELYFIDHNTGTSHWLDPRLS--------KYQKKSLEDCCED-------------- 339
            .||....:||.:|::||||.|:.|..|.:.        :.|:..|:...:.              
Mouse   382 GWERRVDDRGRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAA 446

  Fly   340 ------ELPYGWEKIEDSMYGMYFIDHVNRRTQYENP 370
                  .||.||||..||...:||::|..:.||:|:|
Mouse   447 ENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDP 483

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MagiNP_001286661.1 WW 294..323 CDD:278809 14/28 (50%)
WW 342..372 CDD:238122 14/29 (48%)
PDZ 443..534 CDD:214570
DegQ <455..534 CDD:223343
PDZ_signaling 606..668 CDD:238492
PDZ 925..1011 CDD:214570
PDZ_signaling 1029..1110 CDD:238492
Wwp1NP_796301.2 C2_E3_ubiquitin_ligase 17..140 CDD:175988
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 150..182
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 209..360 48/217 (22%)
Interaction with ERBB4. /evidence=ECO:0000269|PubMed:19561640 345..525 42/182 (23%)
WW 347..376 CDD:278809 9/71 (13%)
WW 379..408 CDD:278809 14/28 (50%)
WW 454..483 CDD:278809 14/28 (50%)
WW 495..524 CDD:238122
HECTc 564..916 CDD:238033
HECTc 587..915 CDD:214523
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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