DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and YAP1

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_005271435.1	Gene:	YAP1 / 10413	HGNCID:	16262	Length:	510	Species:	Homo sapiens

Alignment Length:	533	Identity:	117/533 - (21%)
Similarity:	178/533 - (33%)	Gaps:	191/533 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 GNGSGHGNGTVTGNGEKSGGLAPPGGH---HLR-------------------------------- 172
            |.|...|.|.......::...|||.||   |:|
Human    26 GQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK 90

  Fly   173 -------PPPPPALKKSASAVIGNSA--SREDVASLSGTSSLNSQMSVHNQFISGLPSNGIGSNG 228
                   ||.|.:..:.||...|.:.  :.:.|.:.|..:||.                 :|:
Human    91 LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQ-----------------LGA-- 136

  Fly   229 VHGGAATGRGGPPNSILKGSKENLLQNTYYNGETGDSSLGSECGVGDVQHQNHESHDDPGDGLGP 293
            |..|..|     |..::.|                      .......||....|.:.|.|  .|
Human   137 VSPGTLT-----PTGVVSG----------------------PAATPTAQHLRQSSFEIPDD--VP 172

  Fly   294 LPPKWETAYTERGELYFIDHNTGTSHWLDPR---LSKYQ---------KKSLEDCCEDELPYGWE 346
            ||..||.|.|..|:.||::|...|:.|.|||   ||:..         ::::.:.....||.|||
Human   173 LPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWE 237

  Fly   347 KIEDSMYGMYFIDHVNRRTQYENPVLEAK------RRAAE-----------------------QS 382
            :.......:|:|:|.|:.|.:.:|.|:.:      :|.::                       .|
Human   238 QAMTQDGEIYYINHKNKTTSWLDPRLDPRFGKAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNS 302

  Fly   383 QQQQQMQQQQQQMQEQRSK----------TPTALSETMPTEAAEAHEQE---EDESPMKLPYKFT 434
            .|||||:.||.||:::|.:          .|.|:....|:.|.....||   ..:.|.......|
Human   303 NQQQQMRLQQLQMEKERLRLKQQELLRQVRPQAMRNINPSTANSPKCQELALRSQLPTLEQDGGT 367

  Fly   435 RNPAELQG--QRINTTLLKSSRGLGFTIVGSDGSAGGDVEEFLQIKTV-VPNGPAWLDGQLQTGD 496
            :||....|  |.:.|....||.  .|...|:..|.....:..|.:.:. ||..|   |..|.:.|
Human   368 QNPVSSPGMSQELRTMTTNSSD--PFLNSGTYHSRDESTDSGLSMSSYSVPRTP---DDFLNSVD 427

  Fly   497 VLVYVNDTCVLGYTHHDMVNIFQSILPGERAA----LEVCRGYPLPFDPNDPNTEV-VTTMAVDG 556
            .:    ||       .|.:|  ||.||.::..    ||..           |.|.| :.|:..||
Human   428 EM----DT-------GDTIN--QSTLPSQQNRFPDYLEAI-----------PGTNVDLGTLEGDG 468

  Fly   557 RESDKQRRLNMDG 569
                    :|::|
Human   469 --------MNIEG 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	12/28 (43%)
		WW	342..372	CDD:238122	10/29 (34%)
		PDZ	443..534	CDD:214570	24/95 (25%)
		DegQ	<455..534	CDD:223343	20/83 (24%)
		PDZ_signaling	606..668	CDD:238492
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
YAP1	XP_005271435.1	WW	174..203	CDD:238122	12/28 (43%)
YAP1	XP_005271435.1	WW	232..261	CDD:366073	10/28 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810