DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Magi and Ube3c

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_598668.1	Gene:	Ube3c / 100763	MGIID:	2140998	Length:	1083	Species:	Mus musculus

Alignment Length:	434	Identity:	84/434 - (19%)
Similarity:	143/434 - (32%)	Gaps:	127/434 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   444 RINTTLLK----SSRGLGFTIVGSDGSAGGDVEEFLQIKTVVPNGPAWLDGQLQTGDVLVYVNDT 504
            |:..|.|.    |..|.|.....||..  .|.||     |..||.|.  ||::..    .|:.:.
Mouse   343 RVLQTFLSQLPASPTGTGCPDSTSDSE--DDNEE-----TDQPNSPE--DGRVSA----PYITEE 394

  Fly   505 CVLGYTHHDMVNIFQSILPGERAALEV-------CRGYPLPFDPNDPNTEVVTTMAVDGR----- 557
            |:.........|...:::..:.|:.||       |....:......|...::.::|.:.|
Mouse   395 CLRKLDTKQQTNTLLNLVWRDSASEEVFTRMASICHTLMVQHRMMVPKVRLLYSLAFNARFLRHL 459

  Fly   558 ---ESDKQRRLNMDGNYNFLDLSGEGAKKTSGSGSGFILMKKPEIYTFSIMKGSMGFGFTIADSA 619
               .|....::........|.|...|:..:....|..|    |..|.||.:     |..::.
Mouse   460 WFLISSMTTQMITGSMVPLLQLISRGSPMSFEDSSRII----PLFYLFSSL-----FSHSLI--- 512

  Fly   620 CGQIVKKILDRNCCTQLMEGDVLLEINGLNVRNKPHFYVVE--LLKECSQTTPTAVKIQRTPPDP 682
                  .|.|..     ..||. :|:.|....:...|.:.|  ||..|.:.....:.....|...
Mouse   513 ------SIHDNE-----FFGDP-IEVVGQRQSSMMPFTLEELILLSRCLRDACLGIIKLAYPETK 565

  Fly   683 PANNTLAQLNQVGNVAKLRKNFVGSGLFRSKTPTADLYSTQVKEVLPMRPK---------TPLV- 737
            |               ::|:.:|.:  |:|...|.   ::::::.:.|..|         |.||
Mouse   566 P---------------EVREEYVTA--FQSIGVTT---NSEMQQCIQMEQKRWVQLFKVITNLVK 610

  Fly   738 -----DTRRSRVQIQSPNNEVDDEGDGAA--------AAERK-----------PLQ--------- 769
                 ||||:   ...||:.:.::.|..|        .|.|.           |||
Mouse   611 MLKSRDTRRN---FCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLEVGLES 672

  Fly   770 LQTQGKSNSSLQELDDIPYMDPYPKISRLSERLA---EVTLQGD 810
            |.........|..|.::|::.|:.:..::.:||.   :..:|||
Mouse   673 LPLSVSEERQLAILTELPFVVPFEERVKIFQRLIYADKQEVQGD 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809
		WW	342..372	CDD:238122
		PDZ	443..534	CDD:214570	24/100 (24%)
		DegQ	<455..534	CDD:223343	20/85 (24%)
		PDZ_signaling	606..668	CDD:238492	12/63 (19%)
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
Ube3c	NP_598668.1	Cis-determinant of acceptor ubiquitin-binding. /evidence=ECO:0000250	1..60
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..386		14/40 (35%)
		HECTc	723..1081	CDD:238033
		HECTc	747..1080	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900