DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and HUWE1

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_016884680.1	Gene:	HUWE1 / 10075	HGNCID:	30892	Length:	4501	Species:	Homo sapiens

Alignment Length:	897	Identity:	178/897 - (19%)
Similarity:	307/897 - (34%)	Gaps:	289/897 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPIITATTTSTAGGGAGVAARGVATAKS-------PTDYLMLQQQQQQQQQQQQHFNSNHFYQQQ 58
            ||....||.|:.......:...:.|.:|       ||...:.:..|:.|....:..:|.......
Human  2867 MPDSYPTTPSSTDAATSESKETLGTLQSSQQQPTLPTPPALGEVPQELQSPAGEGGSSTQLLMPV 2931

  Fly    59 QPQQLAPLNASHQHQHSHPHPHPHPVAAATSFATFNGNSNLNSSLANGSSRKFNCSRDNVDDGGD 123
            :|::|.|...|.:.:.:.....|.|...:.|    ...:..:.:|...||:.         :|..
Human  2932 EPEELGPTRPSGEAETTQMELSPAPTITSLS----PERAEDSDALTAVSSQL---------EGSP 2983

  Fly   124 AGEMAAASQTLSSAGTDVVGNGSGHGNGTVTGNGEKSGGLAPP-----------GGHHLRPP--- 174
            ....:.||.||..|    ||:.|..|:......|..:.|.|||           .|...:||
Human  2984 MDTSSLASCTLEEA----VGDTSAAGSSEQPRAGSSTPGDAPPAVAEVQGRSDGSGESAQPPEDS 3044

  Fly   175 PPPALKKSASAVIGNSASREDVASLSGTSSLNSQMSVHNQFISGLPSNGIGSNGVHGGAATGRGG 239
            .|||..:|       |::|:...::||..|       .......|||..........|.:...|.
Human  3045 SPPASSES-------SSTRDSAVAISGADS-------RGILEEPLPSTSSEEEDPLAGISLPEGV 3095

  Fly   240 PPN---SILKGSKENLLQN-------TYYNGETGDSS---LGSECGVGDVQHQNHESHDDPGDGL 291
            .|:   ::....:..:|||       |.....|..|:   :|:. ||.:|.          .:.|
Human  3096 DPSFLAALPDDIRREVLQNQLGIRPPTRTAPSTNSSAPAVVGNP-GVTEVS----------PEFL 3149

  Fly   292 GPLPP-------KWETAYTERGELYFIDHNTGTSHWLDPRL------SKYQKKSLEDCCEDELPY 343
            ..|||       ..:.|..:|.||   ..|..:...:||..      |..::..|||
Human  3150 AALPPAIQEEVLAQQRAEQQRREL---AQNASSDTPMDPVTFIQTLPSDLRRSVLED-------- 3203

  Fly   344 GWEKIEDSMYGMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQQQMQEQ---RSKTPTA 405
                :|||:..                |:.....|..|:.:::|..:|:|.|.|:   .|.| :|
Human  3204 ----MEDSVLA----------------VMPPDIAAEAQALRREQEARQRQLMHERLFGHSST-SA 3247

  Fly   406 LSETMPTEAAEAHEQEEDESPMKLPYKFTRNPAELQGQR-INTTLLKSSRGLGFTIVGSDG---S 466
            ||..:.:.|                  ||   :.|.|.| :..|.|...||..|.:.||..   .
Human  3248 LSAILRSPA------------------FT---SRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRP 3291

  Fly   467 AGGDVEEFLQIKTVVPNGPAWLDGQ-LQTGDVLVYVND--------------TCVLGYTHHDMVN 516
            :|.:|:..|:::     |...||.: |....||::|::              .|....|.|.::.
Human  3292 SGSNVDTLLRLR-----GRLLLDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIR 3351

  Fly   517 IFQSILPGERAA-LEVCRGYPLPFDPNDPNTEVVTTMAVDGRESDKQRRLNMDGNYNFLDLSGEG 580
            ...|||  :|:: .|:|           ..|..:||....|::|.|....:...| ..|||..:.
Human  3352 SLLSIL--QRSSESELC-----------IETPKLTTSEEKGKKSSKSCGSSSHEN-RPLDLLHKM 3402

  Fly   581 AKKTSGSGSGFILMKKPEIYTFSIMKGSMGFGFTIADSACGQIVKKILDRNCCTQLMEGDVLLEI 645
            ..|:|..              .|.:..||       |:|.|          |.|.:.:    ::.
Human  3403 ESKSSNQ--------------LSWLSVSM-------DAALG----------CRTNIFQ----IQR 3432

  Fly   646 NGLNVRNKPHF------------------YVVELLKECSQTTPTAVKIQRT-------------- 678
            :|.....:.|.                  :|::.|.:.::..|:....|||
Human  3433 SGGRKHTEKHASGGSTVHIHPQAAPVVCRHVLDTLIQLAKVFPSHFTQQRTKETNCESDRERGNK 3497

  Fly   679 ---PPDPPANNT---------LAQLNQVGNVAKLRKNFV--------GSGLFRSKTPTADLYSTQ 723
               |....::::         |.:|:.: ||::..||.|        |.|    :|....|.::.
Human  3498 ACSPCSSQSSSSGICTDFWDLLVKLDNM-NVSRKGKNSVKSVPVSAGGEG----ETSPYSLEASP 3557

  Fly   724 VKEVL-----PMRPKTPLVDTRRSR----VQIQSPNNEVDD----EGDGAAA 762
            :.:::     |:..::.|:..:..|    :.|..|.|:|.:    .|.||::
Human  3558 LGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIALPENKVSEAQANSGSGASS 3609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	8/35 (23%)
		WW	342..372	CDD:238122	3/29 (10%)
		PDZ	443..534	CDD:214570	27/110 (25%)
		DegQ	<455..534	CDD:223343	23/97 (24%)
		PDZ_signaling	606..668	CDD:238492	11/79 (14%)
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
HUWE1	XP_016884680.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900