Protein Alignment Magi and magi1a

DIOPT Version :9

• Sequence 1: NP_001286661.1
• Gene: Magi / 37403
• FlyBaseID: FBgn0034590
• Length: 1202
• Species: Drosophila melanogaster
• Sequence 2: XP_021334196.1
• Gene: magi1a / 100319849
• ZFINID: ZDB-GENE-081105-13
• Length: 1507
• Species: Danio rerio
• Alignment Length: 1092
• Identity: 349/1092 - (31%)
• Similarity: 478/1092 - (43%)
• Gaps: 309/1092 - (28%)

  Fly   158 EKSGGLAPPG---GHHLRPPPPPALKKSASAVIGNSASREDVASLSGTSSLNSQMSVHNQFISGL 219
            |:.|.|...|   |::...|.||  |::.|..:....:.:|.:|.|..|..:.|.:...|  |.|
Zfish   144 ERCGELLEIGTYDGNYYGTPKPP--KQALSRTVITHDALQDPSSASQKSREHMQNAGVEQ--SEL 204

  Fly   220 PSNGIGSNGVHGGAATGRGGP---PNSILKGSKENLLQNTYYNGETGDSSLGSECGVGDVQH--Q 279
            ..:...:|...|..|.....|   .....:|:.......||    |.::|:.:.........  .
Zfish   205 QEDADMNNTFTGFLAASMFPPLLCTGDCSRGALRENAAPTY----TLNNSMAAAAAAAAASSPIN 265

  Fly   280 NHESHDDPGDGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRLSKYQKKSLEDCCED----- 339
            .|.:..||   |||:|..||.||||.||:|||||||.|:.|:|||......|.||||.:|
Zfish   266 KHPAEQDP---LGPMPDHWEMAYTENGEIYFIDHNTKTTSWIDPRCQDKPPKPLEDCEDDEEGVH 327

  Fly   340 --------ELPYGWEKIEDSMYGMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQQQMQ 396
                    |||.|||||:|.:||:|::||:||:||||||||||:|:....||:..:..:..::..
Zfish   328 TEELDHDLELPPGWEKIDDPVYGVYYVDHINRKTQYENPVLEARRKKQLDSQRSPEGGRYIREWI 392

  Fly   397 EQRSKTPTALSETMPTEA-----AEAHEQEEDESPMKLPYKFTRNPAELQGQRINTTLLKSSRGL 456
            |:.|.....:...:|:..     .::|...:...|.:....||||||||:|..|:|.||||.||.
Zfish   393 EEHSSAGATIGSYVPSHLETYRDPQSHSAPQAPGPKRGKPFFTRNPAELKGTFISTKLLKSRRGF 457

  Fly   457 GFTIVGSDGSAGGDVEEFLQIKTVVPNGPAWLDGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQSI 521
            |||:||.|     :.:||||||::|.:|||.:||:::||||:|.||||.||||||..:|.|||||
Zfish   458 GFTVVGGD-----EPDEFLQIKSLVLDGPAAVDGKMETGDVIVSVNDTIVLGYTHAQVVKIFQSI 517

  Fly   522 LPGERAALEVCRGYPLPFDPNDPNTEVVTTMAVDGRESDKQRRLNMDGNYNFLDLSGEGAKKTSG 586
            ..|....||:||||||||||:||||.:||::|:..:|.     :.::....|..|.|...:...|
Zfish   518 PIGSMVQLELCRGYPLPFDPDDPNTSLVTSVAILDKEP-----IIVNSQEGFEPLPGLAVQMAPG 577

  Fly   587 SGS-------------------------------------GFILMKKPEIYTFSIMKGSMGFGFT 614
            .||                                     ...:..:||:.|..|.||..|||||
Zfish   578 VGSVGVAPGLEPVPYSAVPEDTLLVTADSCLAYSSDVVTLASAIATQPELITVHIEKGDKGFGFT 642

  Fly   615 IADSAC--GQIVKKILDRNCCTQLMEGDVLLEINGLNVRNKPHFYVVELLKECSQTTPTAVKIQR 677
            ||||..  ||.||:|:|...|..|.|||:|||:|..:|:...|..||:||.:|.:.....:.:||
Zfish   643 IADSLIGGGQKVKQIVDYPRCRGLKEGDILLEVNKRSVQGLSHNQVVDLLSKCPRGGEVTMLVQR 707

  Fly   678 TPPDPPANNTLAQLNQVGNVAKLRKNFVGSGLFRSKTPTADLYSTQVKEVLPMRPKTPLVDTRRS 742
            ....|..:..:.||.        ||:..||....                         |.:.||
Zfish   708 GVLQPKRSPKILQLE--------RKDSQGSSQHS-------------------------VCSHRS 739

  Fly   743 RVQIQSPNNEVDDEGDGAAAAERKPLQLQTQGKSNSSLQELDDIPYMDPYPKISRLSERLAEVTL 807
                    ...|..|      .::|          |..||...:|
Zfish   740 --------THTDSPG------RQEP----------SGPQEPPSVP-------------------- 760

  Fly   808 QGDANGGIYGMPPSMQPLPLPLAHHESCYCYDCQAQRYRPGYFVQAQQAAMSGTTGQYSPLQTAH 872
                       ||..||||: |...|.            ||
Zfish   761 -----------PPPTQPLPV-LPAFEG------------PG------------------------ 777

  Fly   873 LQNERIQRRVNELLSDRRRVGFANLDPPQQMQHSPSWRNGALLDVSEDADQCELTEVTLERQALG 937
             .|..:||:.               ||.:....|.|.....|.|..|.       ::.|.|:..|
Zfish   778 -PNGTLQRKP---------------DPFKIWAQSRSMYESRLPDSQEQ-------DIFLWRKDTG 819

  Fly   938 FGFRIVGGTEEGSQVTVGHIVPGGAADQDQRINTGDEILSIDGINVLNSSHHKVVSLVGESALRG 1002
            |||||:||.|.|..:.:||||..||||:|.|:.:|||::.:||..|:..||..||.|:.::|.:|
Zfish   820 FGFRILGGNEPGEPIYIGHIVKYGAADEDGRLRSGDELICVDGTAVVGKSHQLVVQLMQQAAKQG 884

  Fly  1003 QVTMILRRRRTPL-------------------LQQAPVSTQLRR--------------------- 1027
            .|.:.: ||:||.                   ..|||..|:.:|
Zfish   885 HVNLTV-RRKTPYGGYKGEMDVPPSPASSHHSSTQAPSLTEEKRTPQGSQNSLNTVSSGSGSTSG 948

  Fly  1028 ---------------------YPYDVIVSRHENEGFGFVIISSSNHYYGST-------------I 1058
                                 .||||.:.|.|||||||||:||.:....:|             |
Zfish   949 IGSGGGGGSGSTVVAPAPATLLPYDVEIQRAENEGFGFVIVSSVSRPDVATTLAGNSCVSMPHKI 1013

  Fly  1059 GKLIPGSPADRCGELKVGDRIVAVNRIEIAGMSHGDVVNLIKESGLHVRLTI 1110
            |::|..|||||||:|||||||:|||...|...||.|:||||||:|..|.|.|
Zfish  1014 GRIIECSPADRCGKLKVGDRILAVNSCSITNKSHSDIVNLIKEAGNSVTLRI 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	18/28 (64%)
		WW	342..372	CDD:238122	20/29 (69%)
		PDZ	443..534	CDD:214570	51/90 (57%)
		DegQ	<455..534	CDD:223343	44/78 (56%)
		PDZ_signaling	606..668	CDD:238492	33/63 (52%)
		PDZ	925..1011	CDD:214570	36/85 (42%)
		PDZ_signaling	1029..1110	CDD:238492	50/93 (54%)
magi1a	XP_021334196.1	NK	95..>166	CDD:327404	6/21 (29%)
		MAGI_u1	175..216	CDD:318800	9/42 (21%)
		WW	278..307	CDD:238122	19/28 (68%)
		WW	337..366	CDD:306827	19/28 (68%)
		PDZ	449..530	CDD:214570	49/85 (58%)
		PDZ	626..708	CDD:214570	37/81 (46%)
		MAGI_u5	707..802	CDD:318803	35/235 (15%)
		PDZ_signaling	816..891	CDD:238492	34/75 (45%)
		PDZ_signaling	971..1066	CDD:238492	51/95 (54%)
		PDZ_signaling	1119..1197	CDD:238492
		DUF566	1318..>1498	CDD:309573

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I7892
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	498	1.000	Inparanoid score	I1337
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148234at33208
OrthoFinder	1	1.000	-	-		FOG0000831
OrthoInspector	1	1.000	-	-		otm24407
orthoMCL	1	0.900	-	-		OOG6_102187
Panther	1	1.100	-	-	O	PTHR10316
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3056
SonicParanoid	1	1.000	-	-		X573
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.000