DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and hecw2a

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_009302976.1	Gene:	hecw2a / 100150269	ZFINID:	ZDB-GENE-090311-22	Length:	1475	Species:	Danio rerio

Alignment Length:	672	Identity:	131/672 - (19%)
Similarity:	212/672 - (31%)	Gaps:	230/672 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PTDYLMLQQQQQQQQQQQQHFNSNHFYQQQQPQQLAP--------LN-ASHQHQHSHPHPHPHPV 84
            |||::          ..|.||..:  .....|..::|        || |..........|||.|:
Zfish   311 PTDHV----------SGQMHFKVD--VTSMGPDDVSPETILGAAALNGAPGTPSDDEELPHPLPI 363

  Fly    85 AAATSFATFNGNSNLNSSLANGSSRKFNCSRDNVDDGGDAGEMAAASQTL----SSAGTDVVGNG 145
            ::|....|.:..||.|   ..|||..   |.|....||...:.|.:|..|    .|...|.:
Zfish   364 SSAGPSPTASLGSNRN---GEGSSIP---SPDTEIYGGTLDDEAPSSPDLLQGSFSEQLDAI--- 419

  Fly   146 SGHGNGTVTGNGEKSGGLAPPGGHHLRPPPPPALKKSASAVIGNSASREDVASLSGTSSLNSQMS 210
                 ....|.|::..|.|.|   .||...|...:.||...|.:....:..|:...|.|..:.:.
Zfish   420 -----EAPKGPGDRPLGAASP---KLRSSFPTHTRLSAMLHIDSDEDEDRSAATEATLSTFNGIP 476

  Fly   211 VHNQ-----------FISGL--PSNGIGSNGVHGGAATGRGGPPN-------------------- 242
            ...|           |..|:  ||...|..........|...||.
Zfish   477 RSYQTPPKAAARGAVFDGGIEEPSEEAGLESEVETLNAGEEVPPEPEVVPSSVAPEVETASLMER 541

  Fly   243 --------SILKGSKENLLQNTYYNGETGDSSLGSECGVGDVQ-----HQNHESHDDP-GDGLGP 293
                    .:.:..:|.|.::.....|...||:.|:|..|...     .|..|:..|| |:.|..
Zfish   542 QEEQGREVEVEEEEEEGLARSEELATEVDISSMASDCCPGPASASQEAEQGAEAAIDPGGEDLSD 606

  Fly   294 LPP-KWETAYT----------------------ERGELYFIDHNTGTSHWL-------------- 321
            .|| .:|.|.|                      |..|...:..:|.:..|.
Zfish   607 DPPTTYEVAETAEETHLTNEPEREAPKPEPPTNEEEECEDVTEDTMSRRWSLEATAGVSQEDEDE 671

  Fly   322 ------------------------------DPRLS----------KYQKKSLEDCCEDELPYGWE 346
                                          |.|::          :||:      .::.||..||
Zfish   672 LIPSGDGESVDSETFVTETESELGVPQVNGDQRVNSLPSVRQDIHRYQR------VDEPLPPNWE 730

  Fly   347 KIEDSMYGMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQQQMQEQRSKTPTALSETMP 411
            ...||...::|:|||||.|.::.|......:...:|....||:|..::.|        ::..||.
Zfish   731 ARIDSHGRIFFVDHVNRTTTWQRPTGPPAPQGLTRSSSILQMEQLNRRYQ--------SIRRTMT 787

  Fly   412 TEAAEAHEQEE---DESPMKLPYKFTRNPAELQ-----GQRINTTLLKSSRGLGFTIVGSDGSAG 468
            :|.:|....|:   ||:.:     ..::.:|.:     ||       .|||.....::.|.|:..
Zfish   788 SERSEEPRVEDPPADETDV-----LAQSISEYRRDGIIGQ-------SSSRSRLALLLQSPGAKF 840

  Fly   469 GDVEEFLQIKTVVPNGPAWLDGQLQTGDVLVYVNDTCVL--------------GYTHH-DMVNIF 518
            ....:|..:....|:.            ..::.::||:.              .|.|: |:|| |
Zfish   841 LSSPDFFSVLHSNPSA------------YRMFTSNTCLKHMISKVRRDAQHFERYQHNRDLVN-F 892

  Fly   519 QSILPGERAALEVCRGYPLPFD 540
            .::...::  ||:.||:.:..|
Zfish   893 LNLFSNKQ--LELPRGWEMKHD 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	9/95 (9%)
		WW	342..372	CDD:238122	13/29 (45%)
		PDZ	443..534	CDD:214570	18/105 (17%)
		DegQ	<455..534	CDD:223343	14/93 (15%)
		PDZ_signaling	606..668	CDD:238492
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
hecw2a	XP_009302976.1	HECW_N	50..169	CDD:318711
		C2_NEDL1-like	188..323	CDD:176073	6/21 (29%)
		WW	724..756	CDD:197736	14/31 (45%)
		WW	903..934	CDD:197736	3/10 (30%)
		HECTc	1120..1473	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900