DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and herc5.4

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_005160166.1	Gene:	herc5.4 / 100148091	ZFINID:	ZDB-GENE-090311-7	Length:	995	Species:	Danio rerio

Alignment Length:	1058	Identity:	189/1058 - (17%)
Similarity:	332/1058 - (31%)	Gaps:	332/1058 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 QQPQQL--------APLNASHQHQHSHPHPHPHPVAAATSFATFNGNSNLNSSLANGSSR----- 109
            |.||.|        |.::|...|.          ...:.|...|...||....|..|.::
Zfish   157 QSPQHLQSLCEIPVAQISAGGNHS----------FVLSLSGVVFGWGSNSAGQLGLGDTKDRFVP 211

  Fly   110 ---KFNCSRD--NVDDGGDAGEMAAASQTLSSAGTDVVGNGSGHGNGTVTGNGEKSGGLAPPGGH 169
               |..|.:.  ::..||:      .:.|||..|| |...||| |.|.:..|..|.       .|
Zfish   212 TIVKSLCGKKTVSISCGGE------HTATLSKGGT-VFTFGSG-GFGQLGHNSLKD-------EH 261

  Fly   170 HLRPPPPPALKKSASAVIGNSASREDVASLSGTSSLNSQMSVHNQFI-----SGLPSNGIGSNGV 229
            |      |.|                :|.|.|:.........|:..:     ..:.|.|.|..|.
Zfish   262 H------PRL----------------IAELWGSKVSQVTCGRHHTLVFEESSKLIYSFGCGMQGQ 304

  Fly   230 HGGAATGRGGPPNSIL------KGSKENLLQNTYYN---------GETGDSSLGSECGV---GDV 276
            .|.....:...|..:|      :.:.|.|:...:::         .|:.....||..|:   .|.
Zfish   305 LGNGEQVKQSVPLPVLLPTECTEFTMEKLITGEHHSFALFFKNPGNESEKPKSGSNGGILTLNDR 369

  Fly   277 QHQNHESHDDPGDGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRLSKYQKKSLEDCCEDEL 341
            ......|..||          |.|...|...::....:...|.....|...|| .|:|.|..|
Zfish   370 MIDRWVSESDP----------WPTVKNEINTVFSSAASLNGSFLKTSRDEHYQ-TSVEHCGLD-- 421

  Fly   342 PYGWEKIEDSMYGMY----FIDHVNRRTQYE-NPVLEAKRRAAEQSQQQQQMQQQQQQMQEQRSK 401
               ::.::.|...::    .|..|.:..|.. .|.|.......|..:....:.:....:::||:|
Zfish   422 ---FDLVKTSFAKLFASKSLISEVVKVVQQTLLPSLNPNPTGVEALRLYLLLPELINGLKKQRTK 483

  Fly   402 TPTALSETMPTEAAEAHEQEE-------DESPMKLPYKFTRNPAELQGQRINTTLLKSSRGLGFT 459
            ...||:..:....:.|.:..|       |:...:|...|.:...:|..|..:.|..:|:|.|
Zfish   484 LIEALASKILELNSAARKVLEMYWSRLPDDWFERLIKLFHKESTDLIDQICDETDHQSTRHL--- 545

  Fly   460 IVGSDGSAGGDVEEFLQIKTVVPNGPAWLDGQLQTGDVLVYVNDTCVLGYTHHD-MVNIFQSILP 523
                     .::.|.||:...:                      :|....|||| :::....:|
Zfish   546 ---------KNILEILQMAYQI----------------------SCSTDITHHDFIIHKINDLL- 578

  Fly   524 GERAALEVCRGYPLPFDPNDPNTEVVTTMAVDGRESDKQRRLNMDGNYNFLDLSGEGAKKTSGSG 588
                                   :::.|:..|....:...::|.|    |.|
Zfish   579 -----------------------DLLQTITADLLRMELYMQINED----FHD------------- 603

  Fly   589 SGFILMKKPEIYTFSIMKGSMGFGFTIADSACGQIVKKILDRNCCTQLMEGDVLLEINGLNVRNK 653
                 |.|.|.|.|..:|..:.|.|. :|....|.:..:|...|                 .||.
Zfish   604 -----MVKLEEYYFRTVKILVKFPFA-SDFITKQRMFNLLQEEC-----------------FRNV 645

  Fly   654 PHFYVVELLKECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGN--VAKLRKNFVGSGLFRSKTPT 716
            |:..:       ..:....:.|.|   :....:||..|.|..:  :..|:..|:|......:..:
Zfish   646 PNLAM-------GNSFSNLLHINR---ESVLTDTLQYLRQNTHSFMHPLQVAFIGEDGIDMRGLS 700

  Fly   717 ADLYSTQVKEVLPMRPKTPLVDTRRSRVQIQSPNNEVDDEG-------DGAAAAERKPLQLQTQG 774
            |:.:|...|..:....|  :::...|.:...:|::...::.       .|.|...|..:.:....
Zfish   701 AEFFSLISKSFIEWDKK--ILEVHESSLVWFNPHHTRGNKNFYYLGVICGMALYNRHHINIDFPL 763

  Fly   775 KSNSSLQELDDIPYMDPYPKISRLSERLAEVTLQGDANGGIYGMPPSMQPLPLPLAHHESCYCYD 839
            .....|  |...|.:|...::|.:..|..:..|:.|....:     ::|.|.           :.
Zfish   764 ALFKKL--LQQKPSLDDLEELSPVEARSLKNLLEEDEEEVV-----NLQHLD-----------FT 810

  Fly   840 CQAQRYRP-GYFVQAQQAAMSGTTGQYSPLQ---TAHLQNERIQRRVNELLSDRRRVGFANLDP- 899
            |:.|...| |..:|..:.........|..|:   :...|.|:..|            ||:...|
Zfish   811 CKGQELVPNGSQIQVNKVNRQKYVDLYVDLEFNKSVKTQFEQFTR------------GFSKGCPL 863

  Fly   900 -------PQQMQH----SP--SWRNGALLDVSEDADQC---------------ELTEVTLERQAL 936
                   |:::|.    ||  :|:.   |..|...:.|               ||:|.. :::.|
Zfish   864 DAWTMFHPEELQELLHGSPQYNWKE---LQQSASYEGCSASDELIKNFWTVFFELSEEN-KKKFL 924

  Fly   937 GFGFRIVGGTEEGSQVTVGHIVP-GGAADQDQRINTGD---------------EILSIDGINVLN 985
            .|.:    |||.         || ||.:.:..:|:..|               |.|.:...:.:|
Zfish   925 MFLY----GTER---------VPAGGLSKRALKISQTDCPDPDDHLPEAQTCFERLVLPKYSDIN 976

  Fly   986 SSHHKVVSLVGESALRGQ 1003
            :.|.|::..:...|:.|:
Zfish   977 TLHDKLIHAINSCAVFGR 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	4/28 (14%)
		WW	342..372	CDD:238122	5/34 (15%)
		PDZ	443..534	CDD:214570	14/91 (15%)
		DegQ	<455..534	CDD:223343	10/79 (13%)
		PDZ_signaling	606..668	CDD:238492	10/61 (16%)
		PDZ	925..1011	CDD:214570	21/95 (22%)
		PDZ_signaling	1029..1110	CDD:238492
herc5.4	XP_005160166.1	RCC1_2	117..146	CDD:290274
		RCC1	133..183	CDD:278826	7/35 (20%)
		RCC1	186..235	CDD:278826	10/54 (19%)
		RCC1	239..286	CDD:278826	18/77 (23%)
		RCC1	294..343	CDD:278826	9/48 (19%)
		HECTc	658..993	CDD:294058	69/386 (18%)
		HECTc	682..992	CDD:214523	63/358 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900