DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and magi2

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_031753371.1	Gene:	magi2 / 100101686	XenbaseID:	XB-GENE-493689	Length:	1496	Species:	Xenopus tropicalis

Alignment Length:	1119	Identity:	356/1119 - (31%)
Similarity:	490/1119 - (43%)	Gaps:	350/1119 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 EKSGGLAPPGGHH------LRPP--PPPALKKSASAVIGNSASREDVASLSGTSSLNSQMSVHNQ 214
            ||||.|...|.:.      .:||  |.|.|..:...:......|     :.|....|.  ||.|.
Frog   166 EKSGALLESGTYEENYYGTPKPPAEPAPLLLNATDHIFPGGIPR-----VEGKRKRNK--SVSNM 223

  Fly   215 FISGL--PSNG------IGSNGVHGGAATGRGGPPNSILKGSKENLLQNTYYNGETGDSSLGSE- 270
            ..:|:  |...      :..|||             ::...|.|:..::|..:||.  |||...
Frog   224 EKTGIEPPEEEEEERPVVNGNGV-------------AVTPESSEHEDKSTDASGEI--SSLPYTA 273

  Fly   271 ---CGVGDVQHQNHESHD-------DPGDGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRL 325
               |     ..:..|..|       |..|.||.||..||.||||:||:|||||||.|:.||||||
Frog   274 PLYC-----HSEEKEGTDTIKILKPDDADELGSLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRL 333

  Fly   326 SKYQKKSLEDCCEDELPYGWEKIEDSMYGMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQ 390
            :| :.|..|:|.|:|||||||||:|.:||.|::||:|||||:|||||||||:..:.|....::..
Frog   334 AK-KAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHSMPSTELGT 397

  Fly   391 QQQQMQEQRSKTPTALSETMPTEAAEAHEQEEDESPMKLPYKFTRNPAELQGQRINTTLLKSSRG 455
            |..|.|..|                        |.|:     |||:.::|:|..::|.|.||:.|
Frog   398 QPMQPQVFR------------------------EKPL-----FTRDASQLKGTFLSTILKKSNMG 433

  Fly   456 LGFTIVGSDGSAGGDVEEFLQIKTVVPNGPAWLDGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQS 520
            .||||:|.|     :.:||||:|:|:|.|||..||:::||||:||:|:.|||||||.|:|.||||
Frog   434 FGFTIIGGD-----EPDEFLQVKSVIPEGPAAQDGKMETGDVIVYINEACVLGYTHADVVKIFQS 493

  Fly   521 ILPGERAALEVCRGYPLPFDPNDPNTEVVTTMA--------VDGRESDKQRRLNMDGNYNFLDLS 577
            :..|:...|.:|||||||:||.|....:|:.:|        |:||.       |.:....::..:
Frog   494 VPIGQSVNLVLCRGYPLPYDPEDSANNLVSPLAVIERPPVVVNGRN-------NYETYLEYISRT 551

  Fly   578 GEGA--------------------------------KKTSGSGSGFILMKKPEIYTFSIMKGSMG 610
            .:..                                ...|.:.||   ..:.|:.|.:|:||:.|
Frog   552 SQSVPDVAERPLPSLHSVPTDSPLENTFPPPPPTHDDNVSMASSG---ATQAELMTLTIVKGAQG 613

  Fly   611 FGFTIADSACGQIVKKILDRNCCTQLMEGDVLLEINGLNVRNKPHFYVVELLKECSQTTPTAVKI 675
            ||||||||..||.||:|||...|..|.|||:::|||..||:|..|..||||||||.....|::.|
Frog   614 FGFTIADSPTGQRVKQILDVQGCPGLFEGDLIVEINQQNVQNLNHLEVVELLKECPVGNETSLVI 678

  Fly   676 QRTPPDPPANNTLAQLNQVGNVAKLRKNFVGSGLFRSKTPTADLYSTQVKEVLPMRPKTPLVDTR 740
            ||                             .|.|.                 |.:...|:::
Frog   679 QR-----------------------------GGFFS-----------------PWKSSKPIME-- 695

  Fly   741 RSRVQIQSPNNEVDDEGDGAAAAERKPLQLQTQGKSNSSLQELDDIPYMDPYPKISRLSERLAEV 805
                                        :.:.||...:||.
Frog   696 ----------------------------RWENQGSPQTSLS------------------------ 708

  Fly   806 TLQGDANGGIYGMPPSMQP-LPL-PLAHHESCYCYDCQAQRYRPGYFVQAQQAAMSGTTGQYSPL 868
                         .||:.| :|. |:.|..|                       ...:|..:.|.
Frog   709 -------------APSLPPNVPFAPMLHRSS-----------------------FPDSTEAFDPR 737

  Fly   869 QTAHLQNERIQRRVNELLSDRRRVGFANLDPPQQMQHSPSWRNGALLDVSEDADQCELTEVTLER 933
            :....:.....|.:.|   .|::|      ||         |.|..:| ....|..|| :|.|.|
Frog   738 KPDPYELYEKSRAIYE---SRQQV------PP---------RTGFRVD-GVGPDYKEL-DVHLRR 782

  Fly   934 QALGFGFRIVGGTEEGSQVTVGHIVPGGAADQDQRINTGDEILSIDGINVLNSSHHKVVSLVGES 998
            |..||||||:||.|.|..:.:|.::..|:||:|.|:..|||:|.:|||.|...:|..|:.|:..:
Frog   783 QESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLRPGDELLYVDGIPVAGKTHRYVIDLMHNA 847

  Fly   999 ALRGQVTMILRRRRTPLLQQAP--------VSTQL------RRYP-------------------- 1029
            |..|||.:.:||:...:....|        .|||.      ..||
Frog   848 ARNGQVNLTVRRKVLSIADTCPENGRSPGSASTQHSSPRSDSAYPNSNHSAPCNPSPPEGFTSQS 912

  Fly  1030 ---YDVIVSRHENEGFGFVIISSSNH-YYGST------IGKLIPGSPADRCGELKVGDRIVAVNR 1084
               .||::.|.||||||||||||.|. ..|:|      ||::|.||||||||:|||||||:|||.
Frog   913 MQSSDVVIHRKENEGFGFVIISSLNRPESGATIAVPHKIGRIIEGSPADRCGKLKVGDRILAVNS 977

  Fly  1085 IEIAGMSHGDVVNLIKESGLHVRLTIGVPLKE-----GGPSPGGSSVGVSSNTPL-QASPSLLKA 1143
            ..|..|.|.|:|.|||::||.|.|.| ||.:|     ..||....|.....::|: |.||...::
Frog   978 QSIINMPHADIVKLIKDAGLSVTLCI-VPQEELNSPASAPSSEKQSPMAQQHSPMAQQSPVAQQS 1041

  Fly  1144 QLSHQQQLPQQHLQ 1157
            .::|  .||.|.||
Frog  1042 PVAH--SLPPQPLQ 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	20/28 (71%)
		WW	342..372	CDD:238122	21/29 (72%)
		PDZ	443..534	CDD:214570	46/90 (51%)
		DegQ	<455..534	CDD:223343	42/78 (54%)
		PDZ_signaling	606..668	CDD:238492	38/61 (62%)
		PDZ	925..1011	CDD:214570	38/85 (45%)
		PDZ_signaling	1029..1110	CDD:238492	52/110 (47%)
magi2	XP_031753371.1	PDZ_signaling	15..95	CDD:238492
		NK	117..292	CDD:418433	33/152 (22%)
		WW	302..331	CDD:395320	20/28 (71%)
		WW	348..379	CDD:197736	22/30 (73%)
		PDZ_signaling	425..505	CDD:238492	45/84 (54%)
		PDZ	601..682	CDD:214570	45/109 (41%)
		MAGI_u5	686..757	CDD:406953	18/163 (11%)
		PDZ	774..860	CDD:214570	38/86 (44%)
		PDZ_signaling	917..1004	CDD:238492	52/87 (60%)
		PAT1	<1012..>1133	CDD:401645	13/44 (30%)
		PDZ_signaling	1145..1225	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	110	1.000	Domainoid score	I6240
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	502	1.000	Inparanoid score	I1317
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D284488at2759
OrthoFinder	1	1.000	-	-		FOG0000831
OrthoInspector	1	1.000	-	-		otm48006
Panther	1	1.100	-	-	LDO	PTHR10316
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X573
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160