DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and magi3

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_012811019.1	Gene:	magi3 / 100036692	XenbaseID:	XB-GENE-981179	Length:	1595	Species:	Xenopus tropicalis

Alignment Length:	1219	Identity:	334/1219 - (27%)
Similarity:	483/1219 - (39%)	Gaps:	413/1219 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 CSRDNVDDGGDAGEMAAASQTLSSAGTDVVGNGSGHGNGTVTGNGEKSGGLAPPGGH-------- 169
            ||...:..|.:.||.....:......:.:||.....|:..:..||....||.    |
Frog    28 CSLLEIRGGAEHGEFPYLGRQREDVASFIVGKVPSQGDVLLEVNGTPVSGLT----HRDTLAVIR 88

  Fly   170 HLRPP-------PPPALKK-----------------SASAVIGNSASREDVASLSGTSSLNSQMS 210
            |.|.|       |...:.|                 ....||.::.....:...:.:........
Frog    89 HFREPIRLKTVKPGKVINKDLRHYLSLQFQKGSIDHKLQQVIRDNLYLRTIPCTTRSPRDGEVPG 153

  Fly   211 VHNQFIS-----GLPSNGI-GSNGVHGGAATGRGGP---PNSILKGSKENLLQNTYYNGET---- 262
            |...|||     .|..:|: ..:|.:.|...|...|   ||.......:.:|.:..::.||
Frog   154 VDYNFISVEQFKALEDSGVLLESGTYDGNFYGTPKPPAEPNPFQADPVDQVLFDGEFDTETQRKR 218

  Fly   263 ---------GDSSLGSE----------CGVGDVQHQNHESHDDPG-------------------- 288
                     .||||..|          ...|...|::.:...:.|
Frog   219 TTSVSKMQRTDSSLPEEEDEEEREAVNGSSGSTDHRDRQEPSEWGKTVPSYNQTNSSMDFRNYLT 283

  Fly   289 --DGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRLSKYQKKSLEDCCEDELPYGWEKIEDS 351
              :.|.|||..||.||||.|.:|||||||.|:.||||||.| :.|:.|||.:.|||||||||||.
Frog   284 RDENLEPLPKNWEMAYTEAGMIYFIDHNTKTTTWLDPRLCK-KAKAPEDCEDGELPYGWEKIEDP 347

  Fly   352 MYGMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQQQMQEQRSKTPTALSETMPTEAAE 416
            .||.|::||:|::||::||||||||:                     :...|.      |:|..
Frog   348 QYGTYYVDHINQKTQFDNPVLEAKRK---------------------KQLNPA------PSEGT- 384

  Fly   417 AHEQEEDESPMKLPYKFTRNPAELQGQRINTTLLKSSRGLGFTIVGSDGSAGGDVEEFLQIKTVV 481
            .|::.|:.       :|||:|::|:|..::|:|.||:.|.||||:|.|..     :||||:|.|:
Frog   385 VHQEPENS-------QFTRDPSQLKGALLHTSLKKSAMGFGFTIIGGDRP-----DEFLQVKNVL 437

  Fly   482 PNGPAWLDGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQSILPGERAALEVCRGYPLPFDPNDPNT 546
            .:|||..||::..|||:|.:|.|||||:||.::|.:||.|...:...:.:|||||||.|.:||..
Frog   438 KDGPAAQDGKIAPGDVIVDINGTCVLGHTHAEVVQMFQLIPINQYVNMTLCRGYPLPEDSDDPVA 502

  Fly   547 EVVTTM------------------------AVDGRESDKQRRLNMDGNYN--FLDLSGEGAKKTS 585
            ::|.|:                        .:|..:..|...:.::|..|  .||:..:   :||
Frog   503 DIVNTVPPIINGQMLTQGDINMGSQELKSGVIDLDQRGKPGLMVVNGRLNGPSLDIQDQ---RTS 564

  Fly   586 GSGSGFILMKKPEIYTFSIMKGSMGFGFTIADSACGQIVKKILDRNCCTQLMEGDVLLEINGLNV 650
            .:.||..|   ||:.|..::||..||||.||||..||.||.|||...|..|.:|||:.||...||
Frog   565 MASSGNSL---PELVTIPLLKGPKGFGFAIADSPMGQKVKMILDSQWCPGLQKGDVIKEICHQNV 626

  Fly   651 RNKPHFYVVELLKECSQTTPTAVKIQR-TPPDPPANNTLAQLNQVGNVAKLRKNFVGSGLFRSKT 714
            :|..|..|||:||:........:.|.| .||.|         ::|..|...::..:||
Frog   627 QNLTHIQVVEVLKQFPVGAEVPLLILRGGPPSP---------SKVTKVKSDKQELMGS------- 675

  Fly   715 PTADLYSTQVKEVLPMRPKTPLVDTRRSRVQIQSPNNEVDDEGDGAAAAERKPLQLQTQGKSNSS 779
                     ::.:.|..|
Frog   676 ---------IEAIAPGEP----------------------------------------------- 684

  Fly   780 LQELDDIPYMDPYPKISRLSERLAEVTLQGDANGGIYGMPPSMQPLPLPLAHHESCYCYDCQAQR 844
                                                  :|   ||||.|.....||
Frog   685 --------------------------------------LP---QPLPFPPNLARSC--------- 699

  Fly   845 YRPGYFVQAQQAAMSGTTGQYSPLQTAHLQNERIQRRVNELLSDRRRVGFANLDPPQQMQHSPSW 909
                                 ||    .|....:.::...:..|:         ||.
Frog   700 ---------------------SP----KLDPSEVYKKSKNIFEDK---------PPN-------- 722

  Fly   910 RNGALLDVSEDADQCELTEVTLERQALGFGFRIVGGTEEGSQVTVGHIVPGGAADQDQRINTGDE 974
                    ::|.|      |.|.:|..|||||::||......:.:|.|:|.|||::|.|:...||
Frog   723 --------TKDLD------VFLRKQESGFGFRVLGGDGPDQAIYIGAIIPLGAAEKDGRLRAADE 773

  Fly   975 ILSIDGINVLNSSHHKVVSLVGESALRGQVTMILRRR---------------------RTPLLQQ 1018
            ::.|||:.|...||.:|:.|:..:|..|.|.:.:||:                     .:|.|.:
Frog   774 LICIDGVPVKGKSHKQVLDLMTNAARNGHVLLTVRRQIYYTDKQQEEEELQHTPPAHNGSPRLNR 838

  Fly  1019 APVST--QLRRYPYDVIVSRHENEGFGFVIISSSN--------HYYGSTIGKLIPGSPADRCGEL 1073
            ..||.  :|....||||:.|.:||||||||::|.|        |    .||::|.|||||||.:|
Frog   839 IEVSAIPKLPAEAYDVILQRKDNEGFGFVILTSKNKPPPGVIPH----KIGRVIEGSPADRCRKL 899

  Fly  1074 KVGDRIVAVNRIEIAGMSHGDVVNLIKESGLHVRLTIGVPLKEGGPSPGGSSVGVSSNTPLQASP 1138
            ||||||.|||...|..:||.::|.|||::|..|.||:....:..||..|.:|
Frog   900 KVGDRISAVNGQSIVELSHDNIVQLIKDAGNTVTLTVIAEEEHRGPPSGSNS------------- 951

  Fly  1139 SLLKAQLSHQQQLPQQHLQQAQLNHHHQHLEMPMSMPVPGHGSYLERPS 1187
                   :.|...||..               ||....|.:|: |:|.|
Frog   952 -------ARQSPAPQHR---------------PMGQTQPTYGT-LDRYS 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	19/28 (68%)
		WW	342..372	CDD:238122	19/29 (66%)
		PDZ	443..534	CDD:214570	39/90 (43%)
		DegQ	<455..534	CDD:223343	35/78 (45%)
		PDZ_signaling	606..668	CDD:238492	33/61 (54%)
		PDZ	925..1011	CDD:214570	32/85 (38%)
		PDZ_signaling	1029..1110	CDD:238492	46/88 (52%)
magi3	XP_012811019.1	PDZ_signaling	31..97	CDD:238492	14/69 (20%)
		NK	119..>193	CDD:388413	12/73 (16%)
		WW	290..322	CDD:197736	22/31 (71%)
		WW	337..368	CDD:197736	20/30 (67%)
		PDZ	410..490	CDD:214570	38/84 (45%)
		PDZ	574..655	CDD:214570	37/80 (46%)
		PDZ_signaling	727..808	CDD:238492	32/86 (37%)
		PDZ_signaling	852..937	CDD:238492	47/88 (53%)
		PDZ_signaling	1004..1082	CDD:238492
		PTZ00121	<1202..1571	CDD:173412
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	93	0.259	Domainoid score	I7418
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	502	1.000	Inparanoid score	I1317
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148234at33208
OrthoFinder	1	1.000	-	-		FOG0000831
OrthoInspector	1	1.000	-	-		otm48006
Panther	1	1.100	-	-	O	PTHR10316
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3056
SonicParanoid	1	1.000	-	-		X573
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100