Protein Alignment Magi and magi2b

DIOPT Version :10

• Sequence 1: NP_611551.1
• Gene: Magi / 37403
• FlyBaseID: FBgn0034590
• Length: 1202
• Species: Drosophila melanogaster
• Sequence 2: XP_073799220.1
• Gene: magi2b / 100001810
• ZFINID: ZDB-GENE-141211-6
• Length: 1340
• Species: Danio rerio
• Alignment Length: 1179
• Identity: 355/1179 - (30%)
• Similarity: 481/1179 - (40%)
• Gaps: 412/1179 - (34%)

  Fly   158 EKSGGLAPPGGHH---LRPPPPPALKKSASAVIGNSASREDVASLSGTSSLNSQMSVHNQFISGL 219
            ||||.|...|.:.   ...|.|||   ..:.::.|...:    .|.|...........|:.:|.:
Zfish   166 EKSGALLESGTYEDNFYGTPKPPA---EPTPMLFNVTDQ----LLPGARPSAEWKRKRNKSVSNM 223

  Fly   220 PSNG-------------IGSNGV--------HGGAATGRGG-------PPNSILKGSKENLLQNT 256
            ..:.             |..||:        |...:|...|       ||.:       ..|..|
Zfish   224 EKDSIEPPEEEEEESPIINGNGIAITPESSEHEDKSTDASGDVPVQPCPPET-------PTLTAT 281

  Fly   257 YYNGETGDSSLGSECGVGDVQHQNHESHDDPGDGLGPLPPKWETAYTERGELYFIDHNTGTSHWL 321
            ....|.||:....:    |:|.         .|.:|.||..||.||||:||:|||||||.|:.||
Zfish   282 DVPEEEGDAPKSPQ----DLQE---------NDDMGSLPDNWEMAYTEKGEVYFIDHNTKTTSWL 333

  Fly   322 DPRLSKYQKKSLEDCCEDELPYGWEKIEDSMYGMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQ 386
            ||||:| :.|..|:|.|||||||||||:|.:||.|::||:|||||:||||||||||.
Zfish   334 DPRLAK-KAKPPEECEEDELPYGWEKIDDPIYGSYYVDHINRRTQFENPVLEAKRRI-------- 389

  Fly   387 QMQQQQQQMQEQRSKT---PTALSETMPTEAAEAHEQEEDESPMKLPYKFTRNPAELQGQRINTT 448
               |||||||.|....   ||...|..|                     |||:..:|:|..:.|.
Zfish   390 ---QQQQQMQSQGLSALPLPTIYREKPP---------------------FTRDATQLKGTFLTTV 430

  Fly   449 LLKSSRGLGFTIVGSDGSAGGDVEEFLQIKTVVPNGPAWLDGQLQTGDVLVYVNDTCVLGYTHHD 513
            |.||:.|.||||:|.|     :.:||||:|:|:|.|||..|.::.||||:||:||.||||.||.|
Zfish   431 LQKSNMGFGFTIIGGD-----EPDEFLQVKSVIPEGPAAQDSKMDTGDVIVYINDICVLGTTHAD 490

  Fly   514 MVNIFQSILPGERAALEVCRGYPLPFDPNDPNTE--------VVTTMAVDGRESDKQRRLNMDGN 570
            :|.:|||:..|:...|.:|||||||:||.||:..        |...:.::||.       |.:..
Zfish   491 VVKLFQSVPIGQSVTLVLCRGYPLPYDPEDPSASSSMPPLGLVDHPLLLNGRN-------NYENY 548

  Fly   571 YNFLDLSG-------------------------------------EGAKKTSGSGSGFILMKKPE 598
            ..::.|:|                                     :.....|.||:.......||
Zfish   549 MEYMSLTGRLVPEHGEGLTPLPHPGDTHLDGSQPPSLTTPGPPPDDSVSMASSSGATAGATVAPE 613

  Fly   599 IYTFSIMKGSMGFGFTIADSACGQIVKKILDRNCCTQLMEGDVLLEIN-----GLNVRNKPHFYV 658
            :.:.:|.||:.|||||||||..||.||::|:...|..|.|||:::|||     |||     |..|
Zfish   614 LLSLTITKGAEGFGFTIADSPTGQRVKQVLEPQGCPGLCEGDLIVEINQKCLQGLN-----HTQV 673

  Fly   659 VELLKECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVAKLRKNFVGSGLFRS----------K 713
            |:|||:|...|...:.|||                 |..|         |||.:          .
Zfish   674 VQLLKDCPVGTEATLVIQR-----------------GTTA---------GLFTAWDPAKQWDPQG 712

  Fly   714 TPTADLYSTQVKEVLPMRPKTPLVDTRRSRVQIQSPNNEVDDEGDGAAAAERKPLQLQTQGKSNS 778
            :|...|.:|    :||.....|.....||.|    |::|....|        ||
Zfish   713 SPQTGLSAT----LLPHGAPHPAQTLHRSSV----PDSEAFHLG--------KP----------- 750

  Fly   779 SLQELDDIPYMDPYPKISRLSERLAEVTLQGDANGGIYGMPPSMQPLPLPLAHHESCYCYDCQAQ 843
                       |||.    |.|:          :..||   .|.||||
Zfish   751 -----------DPYD----LYEK----------SRAIY---ESRQPLP----------------- 770

  Fly   844 RYRPGYFVQAQQAAMSGTTG-QYSPLQTAHLQNERIQRRVNELLSDRRRVGFANLDPPQQMQHSP 907
                       ...::.:|| :|..:
Zfish   771 -----------PRTLTDSTGVEYQEV--------------------------------------- 785

  Fly   908 SWRNGALLDVSEDADQCELTEVTLERQALGFGFRIVGG--------TEEGSQVTVGHIVPGGAAD 964
                                ||.|.|:..||||||:||        .|...::.:|.|:....|:
Zfish   786 --------------------EVHLLREKTGFGFRILGGDEAVQAVSPEARDKIVIGAIIENSPAE 830

  Fly   965 QDQRINTGDEILSIDGINVLNSSHHKVVSLVGESALRGQVTMILRRRRTPLLQQA---------- 1019
            :|.|:..|||::|:|.:.|....|..|:.|:..:|..||||:.:|||  .|.||:
Zfish   831 RDGRLRPGDELVSVDRMPVGGRPHRYVIDLMHAAARNGQVTLTVRRR--VLTQQSQPCEENGGSA 893

  Fly  1020 ----------------PVSTQLRRYPYDVIVSRHENEGFGFVIISSSNHYYGST-------IGKL 1061
                            |.:|       ||::.|.|:||||||||||.|....:.       ||::
Zfish   894 NQNSSPRGHAVCPVNLPPTT-------DVVIHRKESEGFGFVIISSLNRPETTNTITVPHKIGRI 951

  Fly  1062 IPGSPADRCGELKVGDRIVAVNRIEIAGMSHGDVVNLIKESGLHVRLTIGVPLKEGGPSPGGSSV 1126
            |.||||||||:|||||||:|||...|..|.|.|:|.|||::||.|.|.| :|.::         |
Zfish   952 IEGSPADRCGKLKVGDRIMAVNCQSIINMPHADIVKLIKDAGLTVTLHI-IPEED---------V 1006

  Fly  1127 GVSSNTPLQASPSLLKAQLSHQQQLPQQHLQQAQLNHHHQHLEMPMSMPVPGHGSYLERPSNNIS 1191
            ..:.:.|.....|.:.||....|.......||:....|       .|.|.| |.|    |:....
Zfish  1007 NGAHSAPTSEKQSPMVAQKHSPQTQSSPATQQSPTMAH-------PSPPAP-HPS----PATTQP 1059

  Fly  1192 ATLALHQQP 1200
            :.|.:.|.|
Zfish  1060 SPLLVDQSP 1068

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_611551.1	WW	294..323	CDD:459800	20/28 (71%)
		WW	342..372	CDD:238122	21/29 (72%)
		PDZ1_MAGI-1_3-like	444..533	CDD:467213	43/88 (49%)
		PDZ2_MAGI-1_3-like	597..677	CDD:467214	39/84 (46%)
		PDZ3_MAGI-1_3-like	926..1010	CDD:467215	32/91 (35%)
		PDZ4_MAGI-1_3-like	1029..1111	CDD:467216	48/88 (55%)
magi2b	XP_073799220.1	None