DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tmtc3 and TMTC1

DIOPT Version :9

Sequence 1:	NP_477246.2	Gene:	Tmtc3 / 37401	FlyBaseID:	FBgn0020312	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_001354804.1	Gene:	TMTC1 / 83857	HGNCID:	24099	Length:	944	Species:	Homo sapiens

Alignment Length:	975	Identity:	303/975 - (31%)
Similarity:	458/975 - (46%)	Gaps:	187/975 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 ACIVCYYNSTQCGLVFDDISAIRDNKDLRPHTPL-INVFLNDFWGTPMRKEQSHKSYRPLTVLTF 106
            |..:||..|.|...|.||:.||.:|.|:||..|| ..:|.|||||..|.:..||||||||.||||
Human    36 ASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHKSYRPLCVLTF 100

  Fly   107 RFNYLLHALEPFGYHLVNLLLHLSVCLLWRRVCRLLLRQCAASGSNAISAPSSSSVSQLNTCAFV 171
            :.|..|..:.||.:|.||::||..|.|:....|                   ..:|.:....|||
Human   101 KLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTC-------------------DKTVFKNRGLAFV 146

  Fly   172 ASLLFAVHPVHTEAVTGVVGRAELLSSICFLAAFLSYAKSVGDSGC-----PRRTN----WLTLF 227
            .:|||||||:|||||.|:||||::|:.:.||.|||||.:|: |.||     |...:    .|:||
Human   147 TALLFAVHPIHTEAVAGIVGRADVLACLLFLLAFLSYNRSL-DQGCVGGSFPSTVSPFFLLLSLF 210

  Fly   228 GCFGSCLLASMLCKEQGITIAGICVVYELFVVHQLRPLH----LCHFVLRLFDERTEQQSPKLAN 288
              .|:|   :||.||.|||:.|:|:||:||.:...:...    ||        .|:.|| |....
Human   211 --LGTC---AMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALC--------PRSPQQ-PGSPQ 261

  Fly   289 PSGI-----------RRWSSSTLW----------------------------------------- 301
            ||.:           :|:.....|
Human   262 PSSLPGHPHRENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSNRNFLLT 326

  Fly   302 -----KRLSFLVGITLTLLVGRVYVMGSQLPIFTRFDNPASAADTP---ERQLTYGYLIYLNCWL 358
                 ||...::...|.:|..|:::||..:|:|:..|||||.  :|   .|.|||.||:..|.||
Human   327 MRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFSEQDNPASF--SPYILTRFLTYSYLLAFNVWL 389

  Fly   359 LLCPSLLCCDWTMGTVPLLQGFTDSRNITTLLTFLA-LGAMVAKTCFTRNLALS-RTLIMCLGWM 421
            ||.|..||.||.:|::||::...|.||:.|:  ||| :.|:::..|......|. :.:::.|.::
Human   390 LLAPVTLCYDWQVGSIPLVETIWDMRNLATI--FLAVVMALLSLHCLAAFKRLEHKEVLVGLLFL 452

  Fly   422 VLPFLPASNLFFPVGFVVAERILYMPSMGYCLLVAYGFEQLQRRGSLSW-QRFSQAAL----AIL 481
            |.||:|||||||.||||||||:|||||||||:|..:|..:|     .:| .|.....|    .:|
Human   453 VFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKL-----CTWLNRCGATTLIVSTVLL 512

  Fly   482 LLTHALKTHQRNLDWRTEYSLFMSGVHVNQRNAKLYNNVGHALENEGKFEEALLYFQQAVRIQTD 546
            ||..:.||.::|..|.:..|||.|||.....|||::.|..:.|:::|:.:||:.:::.|:::...
Human   513 LLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPR 577

  Fly   547 DIGAHINVGRTFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLANLIAKNQT 611
            ...|..|:|....:.   |||:..|.:|..|.||              |.....||.||: |:|.
Human   578 HASALNNLGTLTRDT---AEAKMYYQRALQLHPQ--------------HNRALFNLGNLL-KSQE 624

  Fly   612 RLEEADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEVYEQALLYDNENADIYYNLGVVFL 676
            :.|||..|.:.:|....::..||.:...:|.:..|..:|:|:|:..:....:::|::.|.||..:
Human   625 KKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLV 689

  Fly   677 EQGKSQQAQVYFNKAIELYPEHEQALLNSAILLQELGGEEARRVSRSRLYKVLENDDQNEKVYFN 741
            :.|..::|..::.:||:|.|.|..|::|...|.:.||..........|..:|.    ...::...
Human   690 DTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVA----HKAEILSP 750

  Fly   742 LGMLAMDESSFDEAEQFFKRAIHLKADFRSALFNLALLLADTKRPLDAVPFLNQLIRHHPSHVKG 806
            ||.|..:...::||.|.::.|..|:...|.....||.:||...:..:|....|.::......::.
Human   751 LGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLEC 815

  Fly   807 LILLGDIYI---NHMKDLDEAEKCYRSILHYDPHNTQGLHNLCVV----FVERKRLAKAAACLQY 864
            ..||..||.   ||.|.||..:|.    |...|.:.:.:..|...    ..|:..|.||....:.
Human   816 YRLLSAIYSKQENHDKALDAIDKA----LQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRV 876

  Fly   865 AQRLAP---------------------AEDYIGRHLQIV---------LARLQKINKLPESAPER 899
            |.:|.|                     |..|..|.||:|         ||:|.::.|..:...|:
Human   877 AVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKLDRLEKRLQEVREK 941

Fly 900 899
Human 942 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	DUF1736	323..396	CDD:369859	35/76 (46%)
		PEP_TPR_lipo	<513..871	CDD:274350	92/385 (24%)
		TPR repeat	514..542	CDD:276809	8/27 (30%)
		TPR repeat	547..591	CDD:276809	11/43 (26%)
		TPR repeat	598..625	CDD:276809	10/26 (38%)
		TPR repeat	630..660	CDD:276809	7/29 (24%)
		TPR repeat	665..693	CDD:276809	7/27 (26%)
		TPR repeat	737..764	CDD:276809	7/26 (27%)
		TPR repeat	803..834	CDD:276809	11/33 (33%)
		TPR repeat	839..867	CDD:276809	6/31 (19%)
TMTC1	NP_001354804.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820