DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tmtc3 and Lonrf3

DIOPT Version :9

Sequence 1:NP_477246.2 Gene:Tmtc3 / 37401 FlyBaseID:FBgn0020312 Length:926 Species:Drosophila melanogaster
Sequence 2:XP_006541467.1 Gene:Lonrf3 / 74365 MGIID:1921615 Length:805 Species:Mus musculus


Alignment Length:428 Identity:89/428 - (20%)
Similarity:142/428 - (33%) Gaps:131/428 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   521 GHALENEGKFEEALLYFQQAVRIQTDDIGAHINVGRTFNNLKRYAEA-EQAYVQAKALFPQAKPG 584
            |:.|..|.:.|.|||.:.:|||:..:|...:.|..:.:..|:.:.:| ..|.:..| |.|.   |
Mouse   251 GNRLFREHQVEAALLKYNEAVRLAPNDHLLYSNRSQIYFTLESHEDALHDAEIACK-LRPM---G 311

  Fly   585 VSYHARIA---------PNHLNVFINLANLIAKNQTRLEEADHLYRQAISMRSDYVQAYINRGDI 640
            ...|.|.|         ...|..|:...:|..||::...||                        
Mouse   312 FKAHFRKAQALATLGKVKEALKEFLYCVSLDGKNKSARSEA------------------------ 352

  Fly   641 LMKLNRTAQAQEVYEQALLYDNENADIYYNLGVVFLEQGKSQQAQVYFNKAIELYP---EHEQAL 702
                           |.||:.      :::..|    .|:||:......|.:..:|   ||.:::
Mouse   353 ---------------QRLLFS------FFSPSV----PGESQEHSPDILKLLAPHPRLKEHVESM 392

  Fly   703 L------NSAILLQE-------------LGGEEARRVSRSRLYKVLENDDQNEKVYFNLGMLAMD 748
            .      |...|.||             ...||:..::.|...||...:|:.:           |
Mouse   393 ATEGTSHNLPKLSQENLELPHCSNQEGAAAAEESSSLANSAQGKVSSKEDRKK-----------D 446

  Fly   749 ESSFD---------EAEQFFKRAIHLKADFRSALFNLALLLADTKRPLDAVPFLNQLIRHHPSHV 804
            :...|         :.::..:....::....:.|.| .:...|......|.|.|:     :|   
Mouse   447 QEGEDRDAASVRTGKCQEKKRNRCQIETQEDTELPN-KVSKQDFPAEQGAKPDLS-----NP--- 502

  Fly   805 KGLILLGDIYINHMKDLDEAEKCYRSILHYDPHNTQGLHNLCVVFVER--KRLAKAAACLQYAQR 867
                 ||..   ...|| |...|.|  |.|:|..|...|..|:..:||  ...||...|.....:
Mouse   503 -----LGSF---DASDL-ECSLCMR--LFYEPVTTPCGHTFCLKCLERCLDHNAKCPLCKDVLLQ 556

  Fly   868 LAPAEDYIGRHLQIVLARLQKINKLPESAPERKLAYED 905
            ..|:..|   ...::|..| ....|||...|||..||:
Mouse   557 CLPSRKY---SKNVILEEL-IATFLPEEFKERKRLYEE 590

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tmtc3NP_477246.2 DUF1736 323..396 CDD:369859
PEP_TPR_lipo <513..871 CDD:274350 77/392 (20%)
TPR repeat 514..542 CDD:276809 8/20 (40%)
TPR repeat 547..591 CDD:276809 10/44 (23%)
TPR repeat 598..625 CDD:276809 6/26 (23%)
TPR repeat 630..660 CDD:276809 2/29 (7%)
TPR repeat 665..693 CDD:276809 5/27 (19%)
TPR repeat 737..764 CDD:276809 2/35 (6%)
TPR repeat 803..834 CDD:276809 8/30 (27%)
TPR repeat 839..867 CDD:276809 8/29 (28%)
Lonrf3XP_006541467.1 RING1-HC_LONFs 159..197 CDD:319427
3a0801s09 <244..>359 CDD:273380 32/156 (21%)
TPR repeat 244..272 CDD:276809 8/20 (40%)
TPR repeat 277..307 CDD:276809 6/30 (20%)
TPR repeat 312..335 CDD:276809 4/22 (18%)
PEX10 <456..551 CDD:227861 24/114 (21%)
RING2-HC_LONFs 510..551 CDD:319428 15/43 (35%)
LON_substr_bdg 601..802 CDD:366967
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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