DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tmtc3 and KDM6A

DIOPT Version :9

Sequence 1:NP_477246.2 Gene:Tmtc3 / 37401 FlyBaseID:FBgn0020312 Length:926 Species:Drosophila melanogaster
Sequence 2:XP_011542260.1 Gene:KDM6A / 7403 HGNCID:12637 Length:1489 Species:Homo sapiens


Alignment Length:551 Identity:108/551 - (19%)
Similarity:189/551 - (34%) Gaps:149/551 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   462 LQRRGSLSWQRFSQAALAILLL---THALKTHQRNLDWRTEY---SLFMSGV-----HVNQ---- 511
            |:..|.:....|.|.....|||   ..||..:||....:::|   :.|:.|:     |.|.    
Human    85 LKAEGKVESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKNAAFLYGLGLVYFHYNAFQWA 149

  Fly   512 ---------------RNAKLYNNVGHALENEGKFEEALLYFQQAV------RIQTDDIGAHINVG 555
                           |..:::..:|...:....:|.:|.:||.|:      .:...:|..||  .
Human   150 IKAFQEVLYVDPSFCRAKEIHLRLGLMFKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFHI--A 212

  Fly   556 RTFNNLKRYAEAEQAY---VQAKALFPQAKPGVSYHARIAPNHLNVFINLANLIAKNQTRLEEAD 617
            ..:...::|..|::||   :|.:.|..|.|..|.       ..|....:..:|:....|:...|.
Human   213 HLYETQRKYHSAKEAYEQLLQTENLSAQVKATVL-------QQLGWMHHTVDLLGDKATKESYAI 270

  Fly   618 HLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEVYEQALLYDNENADIYYNLGVVFLEQGKSQ 682
            ...::::....:..|::...|.....:.:...|...|.|::.....:||.:.::||::.:|.:..
Human   271 QYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPM 335

  Fly   683 QAQVYFNKAIELYPEHEQALLNSAILLQELGGEEARRVSRSRLYKVLENDDQNEKVYFNLGMLAM 747
            .|...:..|::|...|..|.:       :||          .||:.........|.|.|    |.
Human   336 DALQAYICAVQLDHGHAAAWM-------DLG----------TLYESCNQPQDAIKCYLN----AT 379

  Fly   748 DESSFDEAEQFFKRAIHLKADF----RSALFNLALLL------------ADTKRPLDAVPFLNQL 796
            ...|.........|..:|:|..    :.:|.|...||            |:......|:....|.
Human   380 RSKSCSNTSALAARIKYLQAQLCNLPQGSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQQA 444

  Fly   797 IR-HHPS--HVKGL---------ILLGDIYINHMKDLDEAEKCYR----------------SILH 833
            .: |||:  .|.||         :.|..|..:.:.||....|..|                ::.|
Human   445 CKPHHPNTEPVLGLSQTPISQQSLPLHMIPSSQVDDLSSPAKRKRTSSPTKNTSDNWSGGHAVSH 509

  Fly   834 YDPHNTQGLHNLCVVFVERKRLAKAAACLQYAQRLAPAEDYIGRHLQIVLARLQKINKLPESAPE 898
              |...|..|:.|:.                .|:|        :||:.:.|....:|      |.
Human   510 --PPVQQQAHSWCLT----------------PQKL--------QHLEQLRANRNNLN------PA 542

  Fly   899 RKLAYEDYDPLEFKLPQD---RPTHKSRKRS 926
            :||..|..:. :|.|.|.   |||..::.||
Human   543 QKLMLEQLES-QFVLMQQHQMRPTGVAQVRS 572

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tmtc3NP_477246.2 DUF1736 323..396 CDD:369859
PEP_TPR_lipo <513..871 CDD:274350 75/410 (18%)
TPR repeat 514..542 CDD:276809 6/33 (18%)
TPR repeat 547..591 CDD:276809 12/46 (26%)
TPR repeat 598..625 CDD:276809 3/26 (12%)
TPR repeat 630..660 CDD:276809 5/29 (17%)
TPR repeat 665..693 CDD:276809 7/27 (26%)
TPR repeat 737..764 CDD:276809 6/26 (23%)
TPR repeat 803..834 CDD:276809 9/55 (16%)
TPR repeat 839..867 CDD:276809 3/27 (11%)
KDM6AXP_011542260.1 TPR repeat 93..121 CDD:276809 9/27 (33%)
TPR 106..399 CDD:223533 59/322 (18%)
TPR repeat 129..159 CDD:276809 4/29 (14%)
TPR_1 130..163 CDD:278916 4/32 (13%)
TPR repeat 164..194 CDD:276809 6/29 (21%)
TPR repeat 205..233 CDD:276809 7/29 (24%)
TPR repeat 243..278 CDD:276809 5/41 (12%)
TPR_17 272..303 CDD:290167 2/30 (7%)
TPR repeat 285..312 CDD:276809 5/26 (19%)
TPR repeat 317..347 CDD:276809 7/29 (24%)
TPR_1 318..351 CDD:278916 8/32 (25%)
TPR repeat 352..378 CDD:276809 8/46 (17%)
JmjC 1151..1215 CDD:214721
JmjC 1185..1293 CDD:202224
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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