Protein Alignment Tmtc3 and Tmtc4

DIOPT Version :10

• Sequence 1: NP_477246.2
• Gene: Tmtc3 / 37401
• FlyBaseID: FBgn0020312
• Length: 926
• Species: Drosophila melanogaster
• Sequence 2: NP_082927.1
• Gene: Tmtc4 / 70551
• MGIID: 1921050
• Length: 741
• Species: Mus musculus
• Alignment Length: 809
• Identity: 269/809 - (33%)
• Similarity: 403/809 - (49%)
• Gaps: 124/809 - (15%)

  Fly    38 LCICVACIVCYYNSTQCGLVFDDISAIRDNKDLRPHTPLINVFLNDFWGTPMRKEQSHKSYRPLT 102
            |.:....::|:..|.....||||..||.:||||:..|||.:::.:||||:.:....|||||||||
Mouse    23 LVVGFVSLLCFARSYDGDFVFDDSEAIVNNKDLQSDTPLGDLWHHDFWGSKLSSNTSHKSYRPLT 87

  Fly   103 VLTFRFNYLLH-ALEPFGYHLVNLLLHLSVCLLWRRVCRLLL--RQCAASGSNAISAPSSSSVSQ 164
            |||||.||.|. ...|.|:|:||:|||.|:.:|...|..:|.  .|....|.....||.:|
Mouse    88 VLTFRINYYLSGGFHPVGFHVVNILLHGSISILMLDVFSVLFGGLQYTGKGQRVHLAPRAS---- 148

  Fly   165 LNTCAFVASLLFAVHPVHTEAVTGVVGRAELLSSICFLAAFLSYAKSVGDSGCPRRTN----WLT 225
                 .:|:|||||||||||.|.||||||:||.::.||.:||.|.::..::|....|:    |:.
Mouse   149 -----LLATLLFAVHPVHTECVAGVVGRADLLCALFFLLSFLGYCQAFKETGNKEGTHSSTFWVL 208

  Fly   226 LFGCFGSCLLASMLCKEQGITIAGICVVYELFVVHQLRPLHLCHFVLRLFDERTEQQSPKLANPS 290
            |....|:   .:|||||||||:.|:..|:::.|:.:|..|.....||.  .:::::.:....|
Mouse   209 LSIFLGA---VAMLCKEQGITVLGLNAVFDILVIGKLDILAAVRKVLH--KDKSQENAGMFKN-- 266

  Fly   291 GIRRWSSSTLWKRLSFLVGITLTLLVGRVYVMGSQLPIFTRFDNPASAADTP-ERQLTYGYLIYL 354
                  ...|::.....:|.|..|.: |..:||:..|.||..|||||.||:. .|.:.|.|...|
Mouse   267 ------GGLLFRIALLTIGGTSMLYI-RWKIMGTGPPAFTEVDNPASFADSMLVRAINYNYYYSL 324

  Fly   355 NCWLLLCPSLLCCDWTMGTVPLLQGFTDSRNITTLLTFLALGAMVAKTCFTRNLALSRTLIMCLG 419
            |.||||||..||.||:||.:||::...|.|.|.....:|.|..::.:...:.:....|.|.:.||
Mouse   325 NAWLLLCPWWLCFDWSMGCIPLIKSVGDWRVIALAALWLCLIGLIFQALCSEDSCKRRILTLGLG 389

  Fly   420 WMVLPFLPASNLFFPVGFVVAERILYMPSMGYCLLVAYGFEQLQRRGSLSWQRFSQAALAI-LLL 483
            ::|:||||||||||.||||||||:||:||.|||:|:.:||..|.|.   :.::...||:.: :||
Mouse   390 FLVIPFLPASNLFFRVGFVVAERVLYLPSAGYCVLLTFGFGALSRH---TKKKKPVAAIILGILL 451

  Fly   484 THALKTHQRNLDWRTEYSLFMSGVHVNQRNAKLYNNVGHALENEGKFEEALLYFQQAVRIQTDDI 548
            .:||:...|:.:||:|..||.|.:.|...|||::.|:|..|.::|....|:.|:::|||:.
Mouse   452 INALRCVIRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADQGNQTAAIKYYREAVRLN---- 512

  Fly   549 GAHINVGRTFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLANLIAKNQTRL 613
                                                        |.:::...||.|:: |.:..|
Mouse   513 --------------------------------------------PKYVHAMNNLGNIL-KERNEL 532

  Fly   614 EEADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEVYEQALLYDNENADIYYNLGVVFLEQ 678
            :||:.|...|:.::.|:..|::|.|.:...|.|..:|::.|..|:.:..:..|.|||||.::.:.
Mouse   533 QEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEEAEQSYRTAIKHRRKYPDCYYNLGRLYADL 597

  Fly   679 GKSQQAQVYFNKAIELYPEHEQALLNSAILLQELGG-EEARRVSRSRLYKVLENDDQNEKVYFNL 742
            .:...|...:..|..|.|||..|..|..|||...|. .:|..|.|..| :::.||   ..:.|:|
Mouse   598 NRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREAL-QLIPND---HSLMFSL 658

  Fly   743 GMLAMDESSFDEAEQFFKRAIHLKADFRSALFNLALLLADTKRPLDAVPFLNQLIRHHPSHVKGL 807
            ..:......:.|:|..|.:||....:..|...|||:|.                  |...|
Mouse   659 ANVLGKSQKYKESEALFLKAIKANPNVASYHGNLAVLY------------------HRWGH---- 701

  Fly   808 ILLGDIYINHMKDLDEAEKCYRSILHYDP 836
                         ||.|:|.|...|..||
Mouse   702 -------------LDSAKKHYEISLQLDP 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	TMTC_DUF1736	323..396	CDD:462468	34/73 (47%)
		TPR	507..762	CDD:440225	61/255 (24%)
		TPR repeat	514..542	CDD:276809	9/27 (33%)
		TPR repeat	547..591	CDD:276809	0/43 (0%)
		TPR repeat	598..625	CDD:276809	9/26 (35%)
		TPR repeat	630..660	CDD:276809	8/29 (28%)
		LapB	634..896	CDD:442196	53/204 (26%)
		TPR repeat	665..693	CDD:276809	8/27 (30%)
		TPR repeat	737..764	CDD:276809	6/26 (23%)
		TPR repeat	803..834	CDD:276809	7/30 (23%)
		TPR repeat	839..867	CDD:276809
Tmtc4	NP_082927.1	TMTC_DUF1736	292..366	CDD:462468	34/73 (47%)
		TPR	475..681	CDD:440225	63/258 (24%)
		TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	482..515		12/80 (15%)
		TPR repeat	482..510	CDD:276809	9/27 (33%)
		TPR repeat	515..545	CDD:276809	9/30 (30%)
		TPR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	516..549		9/33 (27%)
		TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	550..583		8/32 (25%)
		TPR repeat	550..578	CDD:276809	8/27 (30%)
		TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	584..617		10/32 (31%)
		TPR repeat	584..610	CDD:276809	7/25 (28%)
		TPR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	618..651		10/33 (30%)
		TPR repeat	618..646	CDD:276809	10/28 (36%)
		TPR	645..>738	CDD:440225	25/112 (22%)
		TPR repeat	651..681	CDD:276809	8/32 (25%)
		TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	652..685		7/32 (22%)
		TPR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	686..719		15/67 (22%)
		TPR repeat	686..714	CDD:276809	12/62 (19%)