DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tmtc3 and Ttc32

DIOPT Version :9

Sequence 1:	NP_477246.2	Gene:	Tmtc3 / 37401	FlyBaseID:	FBgn0020312	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	XP_003750178.1	Gene:	Ttc32 / 684830	RGDID:	1585566	Length:	148	Species:	Rattus norvegicus

Alignment Length:	177	Identity:	37/177 - (20%)
Similarity:	58/177 - (32%)	Gaps:	73/177 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   623 AISMRSDYVQAYINRGDILMKLNRTAQAQEVY-----------------EQALLYDNENADIYYN 670
            |::|    .||...|||.       .:|:|:|                 :.|..|:|.....|::
  Rat    15 ALAM----AQARFARGDF-------TEARELYSAFIGQCASHRSKCSPEDLATAYNNRGQTKYFS 68

  Fly   671 LGVVFLEQGKSQQAQVYFNKAIELYPEHEQALLNSAILLQELGGEEARRVSRSRLYKVLENDDQN 735
              |.|.|      |...:..|||:.|..|..
  Rat    69 --VDFYE------AMDDYTSAIEILPNFEVP---------------------------------- 91

  Fly   736 EKVYFNLGMLAMDESSFDEAEQFFKRAIHLKADFRSALFNLALLLAD 782
               |:|.|::......||||.:.||:|:.....|:.|:.:|...:.|
  Rat    92 ---YYNRGLIRYRLGYFDEAVEDFKKALDRNPAFQDAVLSLKQTILD 135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	DUF1736	323..396	CDD:369859
		PEP_TPR_lipo	<513..871	CDD:274350	37/177 (21%)
		TPR repeat	514..542	CDD:276809
		TPR repeat	547..591	CDD:276809
		TPR repeat	598..625	CDD:276809	1/1 (100%)
		TPR repeat	630..660	CDD:276809	9/46 (20%)
		TPR repeat	665..693	CDD:276809	6/27 (22%)
		TPR repeat	737..764	CDD:276809	10/26 (38%)
		TPR repeat	803..834	CDD:276809
		TPR repeat	839..867	CDD:276809
Ttc32	XP_003750178.1	TPR_11	14..86	CDD:290150	21/89 (24%)
		TPR repeat	14..48	CDD:276809	10/43 (23%)
		TPR repeat	53..84	CDD:276809	10/38 (26%)
		TPR_11	55..120	CDD:290150	23/109 (21%)
		TPR_1	55..88	CDD:278916	12/40 (30%)
		TPR repeat	89..117	CDD:276809	11/64 (17%)
		TPR_1	92..120	CDD:278916	10/27 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900