DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tmtc3 and SPAG1

DIOPT Version :9

Sequence 1:NP_477246.2 Gene:Tmtc3 / 37401 FlyBaseID:FBgn0020312 Length:926 Species:Drosophila melanogaster
Sequence 2:XP_016869243.1 Gene:SPAG1 / 6674 HGNCID:11212 Length:961 Species:Homo sapiens


Alignment Length:298 Identity:55/298 - (18%)
Similarity:102/298 - (34%) Gaps:118/298 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   636 NRGDILMKLNRTAQAQEVYEQALLY----DNENAD----IYYNLGVVFLEQGKSQQAQVYFNKAI 692
            ::|:.|.:..:.|:|...|..|:..    .:|.||    :|.|....:|::|.........|:|:
Human   485 SQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCIQDCNRAL 549

  Fly   693 ELYPEHEQALLNSAI-----------------LLQ-----ELGGEEARRVSR------------- 722
            ||:|...:.||..|:                 :||     :|..:...|:||             
Human   550 ELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGLQLANDSVNRLSRILMELDGPNWREK 614

  Fly   723 ----------------------------------------SRLYKVLEND------DQNEK---- 737
                                                    .:.:|.|:.:      |:|.|    
Human   615 LSPIPAVPASVPLQAWHPAKEMISKQAGDSSSHRQQGITDEKTFKALKEEGNQCVNDKNYKDALS 679

  Fly   738 --------------VYFNLGMLAMDESSFDEAEQFFKRAIHL-----KADFRSALFNLALLLADT 783
                          :|.|..:..:....|:||:|...:|:.|     ||.:|.||.:..|     
Human   680 KYSECLKINNKECAIYTNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGL----- 739

  Fly   784 KRPLDAVPFLNQLIRHHPSHVKGLILLGDI-YINHMKD 820
            |....::..||::|...||.::..:.|.:: .:.::||
Human   740 KNYQKSLIDLNKVILLDPSIIEAKMELEEVTRLLNLKD 777

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tmtc3NP_477246.2 DUF1736 323..396 CDD:369859
PEP_TPR_lipo <513..871 CDD:274350 55/298 (18%)
TPR repeat 514..542 CDD:276809
TPR repeat 547..591 CDD:276809
TPR repeat 598..625 CDD:276809
TPR repeat 630..660 CDD:276809 6/23 (26%)
TPR repeat 665..693 CDD:276809 8/31 (26%)
TPR repeat 737..764 CDD:276809 8/44 (18%)
TPR repeat 803..834 CDD:276809 3/19 (16%)
TPR repeat 839..867 CDD:276809
SPAG1XP_016869243.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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