DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tmtc3 and ifit8

DIOPT Version :9

Sequence 1:NP_477246.2 Gene:Tmtc3 / 37401 FlyBaseID:FBgn0020312 Length:926 Species:Drosophila melanogaster
Sequence 2:NP_001032654.1 Gene:ifit8 / 641567 ZFINID:ZDB-GENE-051127-17 Length:429 Species:Danio rerio


Alignment Length:445 Identity:98/445 - (22%)
Similarity:172/445 - (38%) Gaps:163/445 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   377 LQGFTDSRNITTLLTFLALGAMVAKTCFTRNLALS--------RTLIMCLGWMVLPFLPASNLFF 433
            ||||.|.          ||          :||.|:        ||:|:..|          ||.:
Zfish    59 LQGFNDE----------AL----------KNLLLAKEEHPNDDRTVIVTYG----------NLAW 93

  Fly   434 PVGFV--VAERILYMPSMGYCLLVAYGFEQLQRR--GSLSWQ--RFSQAAL--AILLLTHALKTH 490
            ...|:  ..|...|:..:.. :|.|:...:|.|.  ...:|.  :||:.:.  |..:...||:..
Zfish    94 VHSFLSNATEAEAYIEKINE-ILRAFPTPELHREVLSEKAWSLLKFSKKSYIRAKEIFLEALQKE 157

  Fly   491 QRNLDWRT--EYSLF-MSGVHVNQRNAKLYNNVGHALENEGKFEE--ALLYFQQAVRIQTDDIGA 550
            ..:.:|.|  .:||| :.|:.:.|     |:.|        :|||  |:|..::|:::..|:...
Zfish   158 PDDKEWNTGLAFSLFRLEGLKIGQ-----YHRV--------RFEESPAVLQLKKALKLDPDNPMI 209

  Fly   551 HINVG-RTFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLANLIAKNQTRLE 614
            .:.:| :.:.|:|. :||.|...||              .::||::|:|.:::|..:.|.|    
Zfish   210 LVYLGLKCYKNIKN-SEAWQYMTQA--------------LKMAPHNLSVVLHVAKFMKKEQ---- 255

  Fly   615 EADHLYRQAISMRSDYVQAYINRGDILMKLNRTA-------------------QAQEVYEQALL- 659
                .|.:|:              |:|:::.:.|                   |..:::...|| 
Zfish   256 ----CYDRAL--------------DVLLEMLKKAPDSSRLHHEVANNYRWKAMQIDDIHNPELLG 302

  Fly   660 ----YDNENADIYYNLGVVF-----------LEQ-GKSQQAQVYFNKAIELYPEHEQA--LLNSA 706
                :..:.|.:  |.|.|:           |:| ||::|.........:|.|...||  .|...
Zfish   303 LCVHHLEKGASL--NPGYVYPQLELALRYAELKQAGKAEQKFTELFSKPDLKPADLQAWHRLYGD 365

  Fly   707 ILLQELGGEEAR-----------RVS------RSRLYKVLENDDQN---EKVYFN 741
            ..|..||.|:|.           |||      |:||.|:|:.|.::   .:|:|:
Zfish   366 FKLYRLGSEKAAVEHYKQGMMLGRVSTEWISCRNRLKKILQRDKRDIYEIRVFFD 420

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tmtc3NP_477246.2 DUF1736 323..396 CDD:369859 6/18 (33%)
PEP_TPR_lipo <513..871 CDD:274350 62/290 (21%)
TPR repeat 514..542 CDD:276809 8/29 (28%)
TPR repeat 547..591 CDD:276809 8/44 (18%)
TPR repeat 598..625 CDD:276809 6/26 (23%)
TPR repeat 630..660 CDD:276809 6/53 (11%)
TPR repeat 665..693 CDD:276809 9/39 (23%)
TPR repeat 737..764 CDD:276809 2/5 (40%)
TPR repeat 803..834 CDD:276809
TPR repeat 839..867 CDD:276809
ifit8NP_001032654.1 TPR_12 50..117 CDD:290160 20/88 (23%)
TPR repeat 206..236 CDD:276809 8/44 (18%)
TPR repeat 241..269 CDD:276809 9/49 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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