Protein Alignment Tmtc3 and ifit12

DIOPT Version :10

• Sequence 1: NP_477246.2
• Gene: Tmtc3 / 37401
• FlyBaseID: FBgn0020312
• Length: 926
• Species: Drosophila melanogaster
• Sequence 2: NP_001177394.1
• Gene: ifit12 / 567504
• ZFINID: ZDB-GENE-120406-2
• Length: 474
• Species: Danio rerio
• Alignment Length: 344
• Identity: 72/344 - (20%)
• Similarity: 134/344 - (38%)
• Gaps: 82/344 - (23%)

  Fly   591 IAPNHLNVFINLANLIAKNQTRLEEADHL--------YRQAISMRSDYVQAYIN-RGDILMKLNR 646
            |..:||: |.||.|       ||||.:.|        .|...||  .|::..:| :.:.|..|:|
Zfish    26 ITKDHLD-FTNLLN-------RLEEQNKLDLGNEEGAARAQCSM--GYLKFLLNCKEEALTHLSR 80

  Fly   647 TAQAQEVYEQALLYDN--ENAD-----IYYNLGVVFLEQGKSQQAQVYFNKAIELYPEHEQALLN 704
            :        :||:.:|  :|.|     .|.|...:........:.:.|.   ::|...||:....
Zfish    81 S--------EALIKENFADNNDKALIVTYGNFAWINYHMENYTECESYL---VKLQKIHERFATE 134

  Fly   705 SAILLQELGGEEARRVSRSRLYKVLENDDQNEKVYFNLGMLAMDESSFDEAEQFFKRAIHLK--- 766
            |:.:.:.||.:....:..||.|                         :|:|.:.|::|:.|.
Zfish   135 SSAVPEVLGEKGWTYLKFSRKY-------------------------YDKAVEVFQKAVELDPTN 174

  Fly   767 ---------ADFRSALFNLALLLADTKRPLDAVPFLNQLIRHHPSHVKGLILLGDIYINHMKDL- 821
                     |.:|:..||......:|    .|:..|.|.|..:|......::||...:|..|.|
Zfish   175 SEWNAGYAIALYRTENFNPPPCTVET----PAIKQLRQAIDLNPDDDVLRVILGIKLLNCSKGLM 235

  Fly   822 DEAEKCYRSILHYDPHNTQGLHNLCVVFVERKRLAKAAACLQYAQRLAPAEDYIGRHLQIVLARL 886
            :|:|:.....|:..|.:...:..:.:...::..:.::...|:.|.:.:|...:|...|.:.. :.
Zfish   236 NESEQLVEKALNQSPEHPHVIRYVGMFLRDQGSVDRSIEILKKALQRSPKSGFICHQLAMCY-KT 299

  Fly   887 QKINKLPESAPERKLAYED 905
            :|||...|.  .||:..::
Zfish   300 KKINLCKEK--RRKVEVDE 316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	TMTC_DUF1736	323..396	CDD:462468
		TPR	507..762	CDD:440225	40/186 (22%)
		TPR repeat	514..542	CDD:276809
		TPR repeat	547..591	CDD:276809	72/344 (21%)
		TPR repeat	598..625	CDD:276809	10/34 (29%)
		TPR repeat	630..660	CDD:276809	7/30 (23%)
		LapB	634..896	CDD:442196	54/282 (19%)
		TPR repeat	665..693	CDD:276809	4/32 (13%)
		TPR repeat	737..764	CDD:276809	4/26 (15%)
		TPR repeat	803..834	CDD:276809	8/31 (26%)
		TPR repeat	839..867	CDD:276809	2/27 (7%)
ifit12	NP_001177394.1	TPR	55..>248	CDD:440225	48/234 (21%)
		TPR repeat	55..83	CDD:276809	8/37 (22%)
		TPR repeat	88..127	CDD:276809	7/41 (17%)
		TPR repeat	139..169	CDD:276809	9/54 (17%)
		LapB	157..406	CDD:442196	35/167 (21%)
		TPR repeat	174..212	CDD:276809	9/41 (22%)
		TPR repeat	217..246	CDD:276809	7/28 (25%)
		TPR repeat	286..331	CDD:276809	8/34 (24%)
		TPR repeat	336..364	CDD:276809
		TPR repeat	374..402	CDD:276809