Protein Alignment Tmtc3 and tmtc2a

DIOPT Version :9

• Sequence 1: NP_477246.2
• Gene: Tmtc3 / 37401
• FlyBaseID: FBgn0020312
• Length: 926
• Species: Drosophila melanogaster
• Sequence 2: NP_001124075.1
• Gene: tmtc2a / 564667
• ZFINID: ZDB-GENE-041210-299
• Length: 844
• Species: Danio rerio
• Alignment Length: 938
• Identity: 292/938 - (31%)
• Similarity: 418/938 - (44%)
• Gaps: 235/938 - (25%)

  Fly    34 LLEFLCICVACIVCYYNSTQCGLVFDDISAIRDNKDLRPHTPLINVFLNDFWGTPMRKEQSHKSY 98
            ::|.:|..|| ::.|.|:......:||..||:.|:||.|.||..|:..:|||||.:....||||:
Zfish     2 IVELVCSAVA-LLLYMNTLSADFCYDDSRAIKTNQDLLPDTPWTNILYDDFWGTLLTHSGSHKSF 65

  Fly    99 RPLTVLTFRFNYLLHALEPFGYHLVNLLLHLSVCLLWRRVCRLLLRQCAASGSNAISAPSSSSVS 163
            |||..::||.||.|..|:|:|:||.|:.||..|..|:...||.||.          ..|.|
Zfish    66 RPLCTISFRLNYFLGGLDPYGFHLFNVGLHCCVTALFTAFCRPLLG----------GGPWS---- 116

  Fly   164 QLNTCAFVASLLFAVHPVHTEAVTGVVGRAELLSSICFLAAFLSYAKSVGDSGCPRRTN------ 222
                  .:|.||||.||:|||||.||||||::.::.|||.:.|.|::.     |..|.|
Zfish   117 ------LLAGLLFASHPIHTEAVAGVVGRADVGAAFCFLLSLLCYSQY-----CRLRHNAAHSSR 170

  Fly   223 -------WLTLFGCFGSCLLASMLCKEQGITIAGICVVYELFVVHQLRPLHLCHFVLRLFDERTE 280
                   ||.  |..|:. .|::|.||||:|:..:..||::.|||:|| |.....||
Zfish   171 VAWRAGSWLA--GSLGAA-AAALLWKEQGVTVLAVSAVYDVCVVHRLR-LRQALIVL-------- 223

  Fly   281 QQSPKLANPSGIRRWSSSTLWKRLSFLVGITLTLLVGRVYVMGSQLPIFTRFDNPASAADTPE-- 343
                       ::|.:.|.| ..|::|||..:.||..|.:.||::.|.|:..|||  |||:|.
Zfish   224 -----------LKRKNRSLL-VSLAWLVGWGIILLTARFHWMGNKPPNFSNSDNP--AADSPHFL 274

  Fly   344 -RQLTYGYLIYLNCWLLLCPSLLCCDWTMGTVPLLQGFTDSRNITT--------LLTFLAL---- 395
             |.||:.||..:|.||||||..|..||:|..||||:...|.||:.:        ||.:.:|
Zfish   275 TRALTFLYLPSVNAWLLLCPDKLSFDWSMDAVPLLKSIADWRNLQSVMFYSGFALLAWFSLRNPP 339

  Fly   396 -----------------GAMVAKTC-------------------FTRNLALSR--------TLIM 416
                             |......|                   ..::|.:|:        .::.
Zfish   340 LQATKINESNGKSHVSNGKYATNGCSHKHNDNHYRDLNLKSNGYHNKSLKVSQKTLPATESVVVF 404

  Fly   417 CLGWMVLPFLPASNLFFPVGFVVAERILYMPSMGYCLLVAYGFEQL-QRRGSLSWQRFSQAALAI 480
            .||.:||||:||:||||.||||||||:||:||||:||||..|...| .|..|.|::.......|.
Zfish   405 SLGLLVLPFIPATNLFFYVGFVVAERVLYIPSMGFCLLVTAGVRSLFVRCRSKSFRALLLTCTAG 469

  Fly   481 LLLTHALKTHQRNLDWRTEYSLFMSGVHVNQRNAKLYNNVGHALENEGKFEEALLYFQQAVRIQT 545
            |:|.::|||.:||.||::|..|:.||:.||.  ||.:.|:|:.|:|:||.
Zfish   470 LVLLYSLKTVRRNQDWKSEEMLYRSGIAVNP--AKAWGNLGNVLKNQGKM--------------- 517

  Fly   546 DDIGAHINVGRTFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLANLIAKNQ 610
                               ||||:||  ..||:        |...:|    ::..||..|:.:|:
Zfish   518 -------------------AEAERAY--RNALY--------YRGNMA----DMLYNLGLLLQENE 549

  Fly   611 TRLEEADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEVYEQALLYDNEN----------- 664
             |..||.|.|:.||..|.....||:|.|.||:......:|:..:.......:||
Zfish   550 -RFSEALHYYKLAIGSRPTLASAYLNVGIILVSQGNIEEAKRTFHTCADIPDENLKDPHAHKSSV 613

  Fly   665 ADIYYNLGVVFLEQGKSQQAQVYFNKAI-----------------ELY----------------- 695
            ....||||.:..:||:.::|...:.:|:                 |.|
Zfish   614 TSCLYNLGKLLHDQGQHEEALSVYKEAVRKMPRQFAPQSLYNMMGEAYMRLNILEEAGHWYRESL 678

  Fly   696 ---PEHEQALLNSAILLQELGGE-EARRVSRSRLYKVLENDDQNEKVYFNLGMLAMDESSFDEAE 756
               |:|..|.|....||..:|.: ||.|.    ..|.:|.|......|.:.|...::||...||.
Zfish   679 KAKPDHIPAHLTYGKLLSIMGQKSEAERY----FLKAIELDPARGNCYMHYGQFLLEESRLAEAA 739

  Fly   757 QFFKRAIHLKADFRSALFNLALLLADTKRPLDAVPFLNQLIRHHPSHVKGLILLGDIYINHMK-D 820
            ...::|..|..:....:|:.|.:|.......:|..:..:.....|.|...|:.||.|.  |:. .
Zfish   740 AMAQKAAELDNEEFDVVFSAAHMLRQASLNEEAETYYGKAADLRPDHPAALMNLGAIL--HLNGK 802

  Fly   821 LDEAEKCYRSILHYDPHN--TQ-GLHNL 845
            |.|||..|...|...|.:  || .||.|
Zfish   803 LKEAESNYLRALQLKPDDLITQSNLHKL 830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	DUF1736	323..396	CDD:369859	36/104 (35%)
		PEP_TPR_lipo	<513..871	CDD:274350	93/386 (24%)
		TPR repeat	514..542	CDD:276809	8/27 (30%)
		TPR repeat	547..591	CDD:276809	9/43 (21%)
		TPR repeat	598..625	CDD:276809	10/26 (38%)
		TPR repeat	630..660	CDD:276809	7/29 (24%)
		TPR repeat	665..693	CDD:276809	8/44 (18%)
		TPR repeat	737..764	CDD:276809	7/26 (27%)
		TPR repeat	803..834	CDD:276809	12/31 (39%)
		TPR repeat	839..867	CDD:276809	5/8 (63%)
tmtc2a	NP_001124075.1	DUF1736	254..328	CDD:285594	33/75 (44%)
		TPR_11	501..562	CDD:290150	27/109 (25%)
		TPR repeat	501..529	CDD:276809	15/63 (24%)
		TPR_1	501..>528	CDD:278916	14/62 (23%)
		TPR repeat	534..564	CDD:276809	12/34 (35%)
		TPR_1	535..>562	CDD:278916	10/31 (32%)
		TPR_12	565..642	CDD:290160	18/76 (24%)
		TPR repeat	569..597	CDD:276809	7/27 (26%)
		TPR repeat	603..642	CDD:276809	8/38 (21%)
		TPR_2	617..646	CDD:285020	8/28 (29%)
		TPR_11	653..716	CDD:290150	14/66 (21%)
		TPR repeat	653..679	CDD:276809	2/25 (8%)
		TPR repeat	684..714	CDD:276809	10/33 (30%)
		TPR_8	685..716	CDD:289924	10/34 (29%)
		TPR_16	757..820	CDD:290168	18/64 (28%)
		TPR_1	787..820	CDD:278916	12/34 (35%)
		TPR repeat	787..815	CDD:276809	10/29 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820