DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tmtc3 and Fkbpl

DIOPT Version :9

Sequence 1:NP_477246.2 Gene:Tmtc3 / 37401 FlyBaseID:FBgn0020312 Length:926 Species:Drosophila melanogaster
Sequence 2:NP_063926.1 Gene:Fkbpl / 56299 MGIID:1932127 Length:347 Species:Mus musculus


Alignment Length:363 Identity:75/363 - (20%)
Similarity:134/363 - (36%) Gaps:88/363 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   560 NLKRYAEAEQAYVQAKAL------FPQAKPGVSYHARIAPNHLNVFI--NLANLIAKNQTRLEEA 616
            |.|..|:.:|....|:.:      |.|..||      :.|..|.|.:  :.||.|.:.|    |.
Mouse    10 NEKNTAQPQQREENAQQILNTAIPFRQRSPG------LLPEALKVGVRPDPANQIVETQ----EI 64

  Fly   617 DH----------LYRQAISMRSDYVQA----YINRGDILMK-------LNRTAQAQEVYEQALLY 660
            :|          .::.:.:..::::||    |...|..:.|       |::.....:....||.:
Mouse    65 EHPVAGFEGDSDQFQVSTNEMAEHLQASDLWYCPDGSFVKKIIVPGHGLDKPKLGSKCQVLALGF 129

  Fly   661 DNENADIYYNLGV--------VFLEQGKSQQAQVYFNKAIELYPEHEQALLNSAILLQELGGEEA 717
            .       :..|:        :.:.|.:.:.......|.:|...:.|:|.::       |.|..|
Mouse   130 P-------FGSGMPEGWTELTIGIGQWREKMWGELMEKCLESMRQGEEAKIH-------LPGSSA 180

  Fly   718 RRVSRSRLYKVLENDDQNEKVYFNLGMLAMDE----------SSFDEAEQFFKRAIHLKADF--- 769
             .:::.||.......|..|........||.:|          .:...|.:.:.||:.|....   
Mouse   181 -PLAKLRLDSFTNGRDSWEMEAMEKEALAKEEHRRGTELFRAGNPQGAARCYGRALRLLLTLPPP 244

  Fly   770 ----RSALF-NLA---LLLADTKRPLDAVPFLNQLIRHHPSHVKGLILLGDIYINHMKDLDEAEK 826
                |:.|: |||   |||.   .|..|....::::...|.|:|.|...| :....:.||::|..
Mouse   245 GPPERTTLYANLAACQLLLG---HPQLAAQSCDRVLEREPGHLKALYRRG-VARAALGDLEKATA 305

  Fly   827 CYRSILHYDPHNTQGLHNLCVVFVE-RKRLAKAAACLQ 863
            .::.:|..||.|......|..|.:: ||:.|..|..|:
Mouse   306 DFKKVLAVDPKNRAAKEELGKVVIQGRKQDAGLARGLR 343

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tmtc3NP_477246.2 DUF1736 323..396 CDD:369859
PEP_TPR_lipo <513..871 CDD:274350 75/363 (21%)
TPR repeat 514..542 CDD:276809
TPR repeat 547..591 CDD:276809 9/36 (25%)
TPR repeat 598..625 CDD:276809 7/38 (18%)
TPR repeat 630..660 CDD:276809 8/40 (20%)
TPR repeat 665..693 CDD:276809 3/35 (9%)
TPR repeat 737..764 CDD:276809 6/36 (17%)
TPR repeat 803..834 CDD:276809 8/30 (27%)
TPR repeat 839..867 CDD:276809 7/26 (27%)
FkbplNP_063926.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24 4/13 (31%)
TPR_11 208..281 CDD:290150 16/75 (21%)
TPR 1 208..241 6/32 (19%)
TPR repeat 208..236 CDD:276809 5/27 (19%)
TPR repeat 249..279 CDD:276809 10/32 (31%)
TPR 2 250..283 10/35 (29%)
TPR_11 252..315 CDD:290150 18/66 (27%)
TPR 3 284..317 9/33 (27%)
TPR repeat 284..312 CDD:276809 6/28 (21%)
TPR_1 285..317 CDD:278916 9/32 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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