DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tmtc3 and tmtc4

DIOPT Version :9

Sequence 1:	NP_477246.2	Gene:	Tmtc3 / 37401	FlyBaseID:	FBgn0020312	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_001166973.1	Gene:	tmtc4 / 560605	ZFINID:	ZDB-GENE-070912-148	Length:	739	Species:	Danio rerio

Alignment Length:	750	Identity:	266/750 - (35%)
Similarity:	390/750 - (52%)	Gaps:	88/750 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LCICVACIVCYYNSTQCGLVFDDISAIRDNKDLRPHTPLINVFLNDFWGTPMRKEQSHKSYRPLT 102
            |......::|:.||.....||||..||.:||||.|.|||.|::.|||||:.:....|||||||||
Zfish    24 LTTAFVALICFINSYDGDFVFDDSEAIINNKDLNPDTPLSNIWKNDFWGSNLSSNSSHKSYRPLT 88

  Fly   103 VLTFRFNYLL-HALEPFGYHLVNLLLHLSVCLLWRRVCRLLLRQCAASGSNA-ISAPSSSSVSQL 165
            |||||.|||| ..|.|.|:|::|:.||..:.:|...|..:|:......|..| :|.|..:|
Zfish    89 VLTFRINYLLAGGLHPVGFHVLNVALHCVISVLMIDVFAILIGGPVQDGKGAKLSLPPKAS---- 149

  Fly   166 NTCAFVASLLFAVHPVHTEAVTGVVGRAELLSSICFLAAFLSYAKSVGDSGCPRRTNWLTLFGCF 230
                |:|:|.||.||||||:|.|:||||:||.::.|..:||.|.|:. ..|..::.:.|.:||..
Zfish   150 ----FLAALFFAAHPVHTESVAGIVGRADLLCALFFQLSFLVYCKAF-QVGGDKKFSVLWIFGSI 209

  Fly   231 GSCLLASMLCKEQGITIAGICVVYELFVVHQLRPLHLCHFVLRLFDERTEQQSPKLANPSGIRRW 295
            ..|.:| |||||||||..|:...|::.:|..|....|.|   ||...|      |.|:..|:.|
Zfish   210 LLCAVA-MLCKEQGITALGVNAAYDILMVCNLNIYELAH---RLLSRR------KSADIGGLPR- 263

  Fly   296 SSSTLWKRLSFL-VGITLTLLVGRVYVMGSQLPIFTRFDNPASAADT-PERQLTYGYLIYLNCWL 358
              :.|..||:.| :|.:| |:..|..:||:..|.||..|||||.|:. ..|.:.|.|...||.||
Zfish   264 --NGLLMRLALLFLGGSL-LMYTRWKIMGTGPPSFTEVDNPASFAENIILRIVNYNYYYSLNAWL 325

  Fly   359 LLCPSLLCCDWTMGTVPLLQGFTDSRNITTLLTFLALGAMVAKTCFTRNLALSRTLIMCLGWMVL 423
            ||||..||.||:||.|||:....|.|.:...:.:..|..:|::..|:::....|||...|..:|:
Zfish   326 LLCPWWLCFDWSMGCVPLISSAADWRIVWPAVLWFCLIGLVSQALFSQDSNKRRTLTFGLVLLVI 390

  Fly   424 PFLPASNLFFPVGFVVAERILYMPSMGYCLLVAYGFEQLQRRGSLSW---QRFSQAALAILLLTH 485
            |||||||:||.||||:|||:||:.|.||||::||.....    |..|   :|..:||...||..:
Zfish   391 PFLPASNVFFRVGFVIAERVLYLSSAGYCLILAYAVGYC----SCHWRKHKRLLRAATLTLLCVN 451

  Fly   486 ALKTHQRNLDWRTEYSLFMSGVHVNQRNAKLYNNVGHALENEGKFEEALLYFQQAVRIQTDDIGA 550
            ..::.||:..||:|.|||.|.:.|...|||::.|||..|.:.|....|:.|:::|||:.
Zfish   452 VTRSAQRSQQWRSEQSLFTSALSVCPLNAKVHYNVGKNLADRGNQSAAVQYYREAVRLH------ 510

  Fly   551 HINVGRTFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLANLIAKNQTRLEE 615
                                                      |.:::...||.|:: |.:..|:|
Zfish   511 ------------------------------------------PKYVHAMNNLGNIL-KERNELKE 532

  Fly   616 ADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEVYEQALLYDNENADIYYNLGVVFLEQGK 680
            |:.|...|:.::.|:..|::|.|.:...|.:..:|::.|..|:.:..:..|.|||||.::.:..:
Zfish   533 AEELLSAAVHIQPDFAAAWMNLGIVQNSLKKFNKAEQSYWNAIRFRKKYPDCYYNLGRLYADLNR 597

  Fly   681 SQQAQVYFNKAIELYPEHEQALLNSAILLQELGG-EEARRVSRSRLYKVLENDDQNEKVYFNLGM 744
            |..|...:..|..|.|:|..|..|..|||...|. .:|..:.:..| |:|..|   ..:.|:|..
Zfish   598 SIDALNAWRNATMLKPDHSLAWNNMVILLDNTGNLAQAELIGKEAL-KILPKD---HTIMFSLAN 658

  Fly   745 LAMDESSFDEAEQFFKRAIHLKADFRSALFNLALL 779
            :...:..:.|:|.||..|:.:..:..|...|||:|
Zfish   659 VLGKQEKYKESEGFFLNALKINPNVASCHGNLAVL 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	DUF1736	323..396	CDD:369859	32/73 (44%)
		PEP_TPR_lipo	<513..871	CDD:274350	65/267 (24%)
		TPR repeat	514..542	CDD:276809	10/27 (37%)
		TPR repeat	547..591	CDD:276809	0/43 (0%)
		TPR repeat	598..625	CDD:276809	9/26 (35%)
		TPR repeat	630..660	CDD:276809	7/29 (24%)
		TPR repeat	665..693	CDD:276809	9/27 (33%)
		TPR repeat	737..764	CDD:276809	7/26 (27%)
		TPR repeat	803..834	CDD:276809
		TPR repeat	839..867	CDD:276809
tmtc4	NP_001166973.1	DUF1736	291..363	CDD:312047	31/71 (44%)
		TPR	479..716	CDD:223533	65/267 (24%)
		TPR repeat	480..508	CDD:276809	10/27 (37%)
		TPR repeat	513..543	CDD:276809	9/30 (30%)
		TPR repeat	548..576	CDD:276809	7/27 (26%)
		TPR repeat	582..608	CDD:276809	8/25 (32%)
		TPR repeat	618..644	CDD:276809	8/26 (31%)
		TPR repeat	649..679	CDD:276809	8/32 (25%)
		TPR repeat	684..712	CDD:276809	4/9 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820