DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tmtc3 and tmtc1

DIOPT Version :9

Sequence 1:	NP_477246.2	Gene:	Tmtc3 / 37401	FlyBaseID:	FBgn0020312	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	XP_001922025.3	Gene:	tmtc1 / 555449	ZFINID:	ZDB-GENE-070705-219	Length:	872	Species:	Danio rerio

Alignment Length:	960	Identity:	307/960 - (31%)
Similarity:	469/960 - (48%)	Gaps:	160/960 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 APSTLPRE---REREGATNSPQRNLLEFLCICVACIVCYYNSTQCGLVFDDISAIRDNKDLRPHT 74
            |||.:.|.   ..|.||    ...||.:..:...|.:||.||.....|.|||.||.:|.|::|.:
Zfish    11 APSPVRRRLCVLPRPGA----GVRLLRYAALVAVCALCYSNSLWGEFVHDDIWAITNNPDVKPGS 71

  Fly    75 PLINVFLNDFWGTPMRKEQSHKSYRPLTVLTFRFNYLLHALEPFGYHLVNLLLHLSVCLLWRRVC 139
            .|.::|.|||||..|....||||||||.:|||:.|.||..|.||.:||||:.||..|..|....|
Zfish    72 SLRSIFTNDFWGKRMADNTSHKSYRPLCILTFKLNILLGGLTPFFFHLVNVFLHCVVTALLMYTC 136

  Fly   140 RLLLRQCAASGSNAISAPSSSSVSQLNTCAFVASLLFAVHPVHTEAVTGVVGRAELLSSICFLAA 204
                :||....||               .:|:.:|||:|||:|||||:|:||||::|:|:.||.|
Zfish   137 ----QQCVFEDSN---------------FSFLTALLFSVHPIHTEAVSGIVGRADVLASMLFLLA 182

  Fly   205 FLSYAKSV-----GDSGCPRRTNW-LTLFGCFGSCLLASMLCKEQGITIAGICVVYELFVVHQLR 263
            ||||.:||     .|...|....| |.|....|:|   :||.||.|:|:.|:||:|: |:|...:
Zfish   183 FLSYIRSVSPIRSADEFPPTVCVWSLALSLLLGTC---AMLVKETGVTVFGVCVLYD-FLVLCRK 243

  Fly   264 PLHLCHFVLRLFDERTEQQSPKLANPSGIRRWSSSTLWKRLSFLVGITLTLLVG-RVYVMGSQLP 327
            ||     :|.|...|.::.. ::::|           :.:.:.:|.:.:|:::. |:::||..:|
Zfish   244 PL-----ILHLSRSRLKELG-RISSP-----------FVKRACVVSLHVTVIMSVRLWLMGGSMP 291

  Fly   328 IFTRFDNPASAADTP---ERQLTYGYLIYLNCWLLLCPSLLCCDWTMGTVPLLQGFTDSRNITTL 389
            :|:..|||||.  :|   .|.|||.||:..|.||||.|.:||.||.:|::||::...|.|||.:|
Zfish   292 LFSEQDNPASF--SPYLLTRFLTYCYLLAFNAWLLLAPIMLCYDWQVGSIPLVESLWDGRNIASL 354

  Fly   390 LTFLALGAMVAKTCFTRNLALSRTLIMCLG------------WMVLPFLPASNLFFPVGFVVAER 442
            ...|.:            ||||...:.||.            ::|.||:|||||||.||||||||
Zfish   355 TLALVM------------LALSLNCVTCLQKMKGKEVLVGLLFLVFPFIPASNLFFRVGFVVAER 407

  Fly   443 ILYMPSMGYCLLVAYGFEQLQRRGSLSWQRFSQAALA----ILLLTHALKTHQRNLDWRTEYSLF 503
            :|||||||||:||.:|..:|....|    |:..|||.    ::||..:.||.|:|..|.:..:||
Zfish   408 VLYMPSMGYCILVVHGLNRLYSVVS----RWGAAALTVSMLVVLLLFSWKTVQQNEIWLSREALF 468

  Fly   504 MSGVHVNQRNAKLYNNVGHALENEGKFEEALLYFQQAVRIQTDDIGAHINVGRTFNNLKRYAEAE 568
            .||:.....|||::.|..:.|:::|:.:||:.:::.|:|:......|..|:|    .|...||..
Zfish   469 RSGIQTLPHNAKVHYNYANFLKDKGRNQEAIYHYKTALRLYPRHASALNNLG----TLTHQAEEA 529

  Fly   569 QAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLANLIAKNQTRLEEADHLYRQAISMRSDYVQA 633
            :.|.: :||            .|.|.|.....||.||: |:|.:.|||:.:.:::|.....:..|
Zfish   530 EVYYR-RAL------------DINPQHNRALFNLGNLL-KSQGKEEEAERMLKESIRFGPHFADA 580

  Fly   634 YINRGDILMKLNRTAQAQEVYEQALLYDNENADIYYNLGVVFLEQGKSQQAQVYFNKAIELYPEH 698
            |.:...:......:.:|.|:|.:.:....|::|::.|.||..::.|:..:|..::.:|:.|.|.|
Zfish   581 YSSLASLYADQGHSKEANEIYTKGIENCPESSDLHNNYGVFLVDTGRGDRAAFHYQEAVRLKPAH 645

  Fly   699 EQALLNSAILLQELGGEEARRVSRSRLYKVLENDDQNEKVYFNLGMLAMDESSFDEAEQFFKRAI 763
            ..|::|...||:.....:...:...|..:|:...|    :...||.|..:...::||.:.::.|.
Zfish   646 YVAMVNLGRLLRSSNDNKEAELWYKRALQVVRKVD----ILTPLGALYYNTGRYEEALEVYREAS 706

  Fly   764 HLKADFRSALFNLALLLADTKRPLDAVPFLNQLIRHHPSHVKGLILLGDIYI---NHMKDLD--- 822
            .|:.|.......||.:||...|..:|......:|....:.::...||..||.   ||.:.||
Zfish   707 TLQPDSTDIWLALAQVLAMAGRSTEAEKMTLGIISKTSNCIECYRLLSAIYSKQGNHTEALDALK 771

  Fly   823 ------EAEKCYRSILHYDPHNTQGLHNLCVVFVERKRLAKAAACLQYAQRLAPAE--------- 872
                  .:|...|:.||:...|.         ..|...|.:|....:.|..|.|.:
Zfish   772 TALQQESSEPAVRAELHFSMGNQ---------LREMNELDRAFQSYKLAVELKPEQSQAWMNMGG 827

  Fly   873 ------DYIGRHLQIVLARLQKINKLPESAPERKLAYED---YDPLEFKL 913
                  ||....:....|.|        .:|:.||..|:   .|.||.||
Zfish   828 IQHIKGDYAAARMYYQRALL--------LSPDSKLLKENLAKLDRLEKKL 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	DUF1736	323..396	CDD:369859	34/75 (45%)
		PEP_TPR_lipo	<513..871	CDD:274350	88/369 (24%)
		TPR repeat	514..542	CDD:276809	8/27 (30%)
		TPR repeat	547..591	CDD:276809	9/43 (21%)
		TPR repeat	598..625	CDD:276809	9/26 (35%)
		TPR repeat	630..660	CDD:276809	5/29 (17%)
		TPR repeat	665..693	CDD:276809	7/27 (26%)
		TPR repeat	737..764	CDD:276809	6/26 (23%)
		TPR repeat	803..834	CDD:276809	11/42 (26%)
		TPR repeat	839..867	CDD:276809	4/27 (15%)
tmtc1	XP_001922025.3	DUF1736	287..361	CDD:285594	34/87 (39%)
		TPR_11	478..541	CDD:290150	20/79 (25%)
		TPR_2	479..512	CDD:285020	9/32 (28%)
		TPR repeat	479..507	CDD:276809	8/27 (30%)
		TPR repeat	512..539	CDD:276809	9/43 (21%)
		TPR_17	532..565	CDD:290167	15/46 (33%)
		TPR repeat	544..572	CDD:276809	9/28 (32%)
		TPR_11	545..609	CDD:290150	15/64 (23%)
		TPR_11	578..643	CDD:290150	14/64 (22%)
		TPR repeat	578..606	CDD:276809	5/27 (19%)
		TPR repeat	611..641	CDD:276809	7/29 (24%)
		TPR repeat	646..674	CDD:276809	5/27 (19%)
		TPR_11	648..710	CDD:290150	14/65 (22%)
		SNAP	655..>856	CDD:305195	46/221 (21%)
		TPR repeat	661..711	CDD:276937	10/53 (19%)
		TPR_14	685..722	CDD:290164	10/36 (28%)
		TPR_19	693..756	CDD:291240	14/62 (23%)
		TPR repeat	712..742	CDD:276809	7/29 (24%)
		TPR repeat	715..760	CDD:276937	11/44 (25%)
		TPR repeat	747..775	CDD:276809	8/27 (30%)
		TPR repeat	763..814	CDD:276937	12/59 (20%)
		TPR_11	784..850	CDD:290150	14/82 (17%)
		TPR repeat	784..814	CDD:276809	8/38 (21%)
		TPR repeat	815..851	CDD:276937	5/43 (12%)
		TPR repeat	819..846	CDD:276809	2/26 (8%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820