Protein Alignment Tmtc3 and tmtc2b

DIOPT Version :10

• Sequence 1: NP_477246.2
• Gene: Tmtc3 / 37401
• FlyBaseID: FBgn0020312
• Length: 926
• Species: Drosophila melanogaster
• Sequence 2: XP_021323440.2
• Gene: tmtc2b / 555381
• ZFINID: ZDB-GENE-081031-100
• Length: 837
• Species: Danio rerio
• Alignment Length: 935
• Identity: 289/935 - (30%)
• Similarity: 415/935 - (44%)
• Gaps: 239/935 - (25%)

  Fly    34 LLEFLCICVACIVCYYNSTQCGLVFDDISAIRDNKDLRPHTPLINVFLNDFWGTPMRKEQSHKSY 98
            :.|.:|..|| ::.|.|:......:||..||:.|:||.|.||.||:|.:|||||.:....|||||
Zfish     2 IAELVCSAVA-LLLYVNTLDADFCYDDSRAIKTNQDLFPETPWINIFYDDFWGTLLTHSGSHKSY 65

  Fly    99 RPLTVLTFRFNYLLHALEPFGYHLVNLLLHLSVCLLWRRVCRLLLRQCAASGSNAISAPSSSSVS 163
            |||..|:||.||.|..|:|:||||||::||.:...|:..:..|||      ||...|
Zfish    66 RPLCTLSFRLNYALGGLDPWGYHLVNVVLHCTATGLFSSLSSLLL------GSGCWS-------- 116

  Fly   164 QLNTCAFVASLLFAVHPVHTEAVTGVVGRAELLSSICFLAAFLSYAKSVGDSGCPRRT------N 222
                  .:|.||||.||:|||||.|:||||::.:::.:|.|...|.:.     |..||      :
Zfish   117 ------LLAGLLFAAHPIHTEAVAGIVGRADVGAALFYLLALRCYIRH-----CTLRTSSAHGWS 170

  Fly   223 WLTLFGCFGSCLLASMLCKEQGITIAGICVVYELFVVHQLRPLHLCHFVLRLFDERTEQQSPKLA 287
            |:...|..| |...|||.||||:|:..:..:|::||.|:|:                .||.|.|.
Zfish   171 WMWFLGTLG-CASCSMLWKEQGVTVLAVAAIYDVFVFHKLK----------------LQQVPALF 218

  Fly   288 NPSGIRRWSSSTLWKRLSFLVGITL------TLLVGRVYVMGSQLPIFTRFDNPASAADTP---E 343
            ...           |.|..|:.:.|      .||..|:|.||::.|.|:..|||  |||.|   .
Zfish   219 QKK-----------KNLRLLLSVFLLGFWGVILLACRLYWMGNKPPNFSNSDNP--AADCPCFLT 270

  Fly   344 RQLTYGYLIYLNCWLLLCPSLLCCDWTMGTVPLLQGFTDSRNITTLLTFLALGAM---------- 398
            |.||:.:|..:|.||||||.:|..||:|..:|||:...|.||:.|:..:.:|.::
Zfish   271 RTLTFLFLPAINVWLLLCPDMLSFDWSMDALPLLRSIADWRNLHTVAFYTSLLSLAWFGLHLYPT 335

  Fly   399 -----------VA----------------KTCFTRNLALSRT-----------------LIMCLG 419
                       ||                .|.::.::.::.|                 ::..||
Zfish   336 KSKETNGKAHHVANGKSSNGHSCSTDYENSTFYSNSVQMNGTNGTVKHYSSSLPTTESLVVFSLG 400

  Fly   420 WMVLPFLPASNLFFPVGFVVAERILYMPSMGYCLLVAYG----FEQLQRRGSLSWQRFSQAALAI 480
            .:.:||:||:||||.||||||||:||:||||||||||.|    :.:|:|:.|.:......|||.:
Zfish   401 LLAVPFIPATNLFFYVGFVVAERVLYIPSMGYCLLVALGMRCLYVRLRRKSSRTLVLGCSAALVL 465

  Fly   481 LLLTHALKTHQRNLDWRTEYSLFMSGVHVNQRNAKLYNNVGHALENEGKFEEALLYFQQAVRIQT 545
            |.   .:||..||.||:.|..|:.||:.||.  ||.:.|:|:.|:|:||.|
Zfish   466 LF---GIKTVLRNRDWQNEEMLYKSGISVNP--AKAWGNLGNVLKNQGKVE-------------- 511

  Fly   546 DDIGAHINVGRTFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLANLIAKNQ 610
                                ||||||..|           .|:.|   |..::..||..|:.:|
Zfish   512 --------------------EAEQAYRNA-----------LYYRR---NMADMLYNLGLLLQEN- 541

  Fly   611 TRLEEADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEVYEQALLYDNEN----------- 664
            :|..||.|.|:.||..|.....||:|.|.:||...|..:|:..:.......:||
Zfish   542 SRFSEALHYYKLAIGSRPTLASAYLNTGIVLMNQGRLEEAKRTFVTCAEISDENLKDPHAHKSSV 606

  Fly   665 ADIYYNLGVVFLEQGKSQQAQVYFNKAIE----------LY------------------------ 695
            ....||||.:..|||..::|...:.:||:          ||
Zfish   607 TSCLYNLGKLLHEQGHQEEAISVYKEAIQKMPRQFAPQSLYNMMGEAFMRLNKLTEAEHWYKESL 671

  Fly   696 ---PEHEQALLNSAILLQELGGE-EARRVSRSRLYKVLENDDQNEKVYFNLGMLAMDESSFDEAE 756
               |:|..|.|....||...|.: ||.:.    ..|.:|.|......|.:.|...::||...||.
Zfish   672 RAKPDHIPAHLTYGKLLAMTGQKTEAEKF----FLKAIELDPTKGNCYMHYGQFLLEESRLLEAA 732

  Fly   757 QFFKRAIHLKADFRSALFNLALLLADTKRPLDAVPFLNQLIRHHPSHVKGLILLGDIYINHMK-D 820
            :..::|..|..:....:|:.|.:|........|..:..|.....|::...|:.||.|.  |:. .
Zfish   733 EMAEKAAQLDTEEFDVVFSAAHMLRQASLNDAAEKYYRQAASLRPNYPAALMNLGAIL--HLNGK 795

  Fly   821 LDEAEKCYRSILHYDPHNTQGLHNL 845
            |.|||..|...|...|.:|....||
Zfish   796 LQEAEANYLRALQLKPDDTITQSNL 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	TMTC_DUF1736	323..396	CDD:462468	32/75 (43%)
		TPR	507..762	CDD:440225	73/303 (24%)
		TPR repeat	514..542	CDD:276809	9/27 (33%)
		TPR repeat	547..591	CDD:276809	8/43 (19%)
		TPR repeat	598..625	CDD:276809	10/26 (38%)
		TPR repeat	630..660	CDD:276809	8/29 (28%)
		LapB	634..896	CDD:442196	62/262 (24%)
		TPR repeat	665..693	CDD:276809	9/27 (33%)
		TPR repeat	737..764	CDD:276809	7/26 (27%)
		TPR repeat	803..834	CDD:276809	11/31 (35%)
		TPR repeat	839..867	CDD:276809	3/7 (43%)
tmtc2b	XP_021323440.2	None