DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tmtc3 and Spag1

DIOPT Version :9

Sequence 1:	NP_477246.2	Gene:	Tmtc3 / 37401	FlyBaseID:	FBgn0020312	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_651514.1	Gene:	Spag1 / 43239	FlyBaseID:	FBgn0039463	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	402	Identity:	72/402 - (17%)
Similarity:	138/402 - (34%)	Gaps:	131/402 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   558 FNNLKRYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLANLIAKNQTRLEEADHLYRQ 622
            :.:|:|.||.     :.|||.|.:|                       :.:.:.:::::..|.:.
  Fly    49 YPDLQRCAEE-----KLKALKPDSK-----------------------LFRYEEQIKQSTDLDKT 85

  Fly   623 AISMRSDYVQAYINRGDILMKLNRTAQAQEVYEQALLYDNENADIYYNLGVVFLEQ--------- 678
            .:....|:..|...:.:.|.:|.:..|            |.|......|..:.||:
  Fly    86 ELKPILDWTDAIKTKDNALNELKKVKQ------------NLNLPSVRKLSKIDLEKESKTEKPKP 138

  Fly   679 ---------GKSQQAQVY---FNKAIELYPEHEQALLNSAILLQELGGEEARRVSRSRLYKVLEN 731
                     .|:::|::.   :.|..:..|:.|       ||..:|..|              .:
  Fly   139 APKATSPSNTKNKEARIKSTDYRKWDKYDPDEE-------ILRMDLNEE--------------RD 182

  Fly   732 DDQNEKVYFNLGMLAMDESSFDEAEQFFKRAIHLKADFRSALFNLALLLADTKRPLDAVPFLNQL 796
            .:|.||:..|.......:....|.:..::|       .::.|.||:.|..:            |.
  Fly   183 QEQREKIISNHSKSVTTDKLQSERDSLYER-------LQAQLKNLSQLEKE------------QF 228

  Fly   797 IRHHPSHVKGLILLGDIYINH---MKDLDEAEKCYRSILHYDPHN-TQGLHNLCVVFVERKR--- 854
            ...|  .::|         |.   .|:.:.|.:.|...:.|||.| ....:|..|..::.|:
  Fly   229 AERH--RLRG---------NESFKAKEYENAIEEYNCSIIYDPENAVHAYNNRAVAHLKLKKYFS 282

  Fly   855 -LAKAAACLQYAQ-------RLAPAEDYIGRHLQIVLARLQKINKLPESAPERKLAYEDYDPLEF 911
             ::...||||...       |:|.|.:..|:||:    .|....||.:..|:..:|.:..:.|..
  Fly   283 AISDCQACLQIDPMNIKAHLRMAEAHNAEGKHLE----SLNVYKKLLDFEPDNAIAKKAVEKLTS 343

  Fly   912 KLPQDRPTHKSR 923
            .|.:..|:..:|
  Fly   344 MLGEVAPSSATR 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	DUF1736	323..396	CDD:369859
		PEP_TPR_lipo	<513..871	CDD:274350	59/348 (17%)
		TPR repeat	514..542	CDD:276809
		TPR repeat	547..591	CDD:276809	9/32 (28%)
		TPR repeat	598..625	CDD:276809	1/26 (4%)
		TPR repeat	630..660	CDD:276809	4/29 (14%)
		TPR repeat	665..693	CDD:276809	6/48 (13%)
		TPR repeat	737..764	CDD:276809	4/26 (15%)
		TPR repeat	803..834	CDD:276809	5/33 (15%)
		TPR repeat	839..867	CDD:276809	7/38 (18%)
Spag1	NP_651514.1	TPR_11	229..295	CDD:290150	17/76 (22%)
		TPR repeat	229..257	CDD:276809	6/38 (16%)
		TPR repeat	262..293	CDD:276809	7/30 (23%)
		TPR_11	266..329	CDD:290150	16/66 (24%)
		TPR	266..297	CDD:197478	7/30 (23%)
		TPR repeat	298..326	CDD:276809	9/31 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900