DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tmtc3 and Tmtc1

DIOPT Version :9

Sequence 1:	NP_477246.2	Gene:	Tmtc3 / 37401	FlyBaseID:	FBgn0020312	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_945318.2	Gene:	Tmtc1 / 387314	MGIID:	3039590	Length:	942	Species:	Mus musculus

Alignment Length:	996	Identity:	318/996 - (31%)
Similarity:	476/996 - (47%)	Gaps:	169/996 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PREREREGATNSPQRNLLEFLCICVACIVCYYNSTQCGLVFDDISAIRDNKDLRPHTPL-INVFL 81
            |..|.|.|...:....||     ..|..:||..|.:...|.||:.||.:|.|:||.||| ..:|.
Mouse    15 PSRRPRCGLVPAGAAALL-----AGASCLCYGRSLRGEFVHDDVWAIVNNPDVRPGTPLRWAIFA 74

  Fly    82 NDFWGTPMRKEQSHKSYRPLTVLTFRFNYLLHALEPFGYHLVNLLLHLSVCLLWRRVCRLLLRQC 146
            |||||..:....||||||||.||:||.|..|..:.||.:|.||::||..|.|:....|
Mouse    75 NDFWGKGLADSTSHKSYRPLCVLSFRLNIFLTGMNPFYFHAVNVILHCLVTLVLMYTC------- 132

  Fly   147 AASGSNAISAPSSSSVSQLNTCAFVASLLFAVHPVHTEAVTGVVGRAELLSSICFLAAFLSYAKS 211
                        ..:|.:....|||.:|||||||||||||.|:||||::|:.:.||.|||||.:|
Mouse   133 ------------DKTVFKNRGLAFVTALLFAVHPVHTEAVAGIVGRADVLACLLFLLAFLSYQRS 185

  Fly   212 VGDSGC-----PRRTN----WLTLFGCFGSCLLASMLCKEQGITIAGICVVYELFVVHQLRPLH- 266
            : |.||     |...:    .|:||  .|:|   :||.||.|||:.|:|:||:||     .|.|
Mouse   186 L-DQGCAGQCFPTTASPFFLLLSLF--LGTC---AMLVKETGITVFGVCLVYDLF-----SPSHK 239

  Fly   267 --------LCHFVLRLFDERTEQQSPKLANPSGIRR---------W------------------S 296
                    :|..  ......:.|.|.:.|:|....|         |                  |
Mouse   240 QDKLSNGAVCQH--SSGQPGSPQPSSQQAHPHRESRKQRFPHKDSWGGCHSPLPPEPKSSGFPMS 302

  Fly   297 SSTLWKRLSFLVGIT-----LTL-----------------LVGRVYVMGSQLPIFTRFDNPASAA 339
            ...:|..:..|.|.|     |||                 |..|:::||..:|:|:..|||||.
Mouse   303 PRAMWSLMRCLTGSTNRNFLLTLRPFLKRAILVISYVTVILYFRLWIMGGTMPLFSEQDNPASF- 366

  Fly   340 DTP---ERQLTYGYLIYLNCWLLLCPSLLCCDWTMGTVPLLQGFTDSRNITTLLTFLALGAMVAK 401
             :|   .|.|||.||:..|.||||.|..||.||.:|::||::...|.||:.|:|..:.: |:::.
Mouse   367 -SPYILTRFLTYSYLLAFNVWLLLAPITLCYDWQVGSIPLVETIWDVRNLATILLAVVM-ALLSL 429

  Fly   402 TCFTRNLALSRTLIMC-LGWMVLPFLPASNLFFPVGFVVAERILYMPSMGYCLLVAYGFEQ---- 461
            .|......|....::. |.::|.||:|||||||.||||||||:|||||||||:|..:|..:
Mouse   430 HCVAAFKRLEHKEVLAGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCAG 494

  Fly   462 LQRRGSLSWQRFSQAALAILLLTHALKTHQRNLDWRTEYSLFMSGVHVNQRNAKLYNNVGHALEN 526
            |.|.|:.|    ..|:..:|||..:.||.::|..|.:..|||.|||.....|||::.|..:.|::
Mouse   495 LSRCGATS----LMASTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKD 555

  Fly   527 EGKFEEALLYFQQAVRIQTDDIGAHINVGRTFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHARI 591
            :|:.:||:.:::.|:::......|..|:|..   .|..|||:..|.:|..|.||
Mouse   556 QGRNKEAIYHYRTALKLYPRHASALNNLGTL---TKDMAEAKMYYQKALQLHPQ----------- 606

  Fly   592 APNHLNVFINLANLIAKNQTRLEEADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEVYEQ 656
               |.....||.||: |:|.:.|||..|.:::|....|:..||.:...:|.:..|..:|:::|:.
Mouse   607 ---HNRALFNLGNLL-KSQEKTEEAIMLLKESIKYGPDFADAYSSLASLLAEQERFKEAEDIYQA 667

  Fly   657 ALLYDNENADIYYNLGVVFLEQGKSQQAQVYFNKAIELYPEHEQALLNSAILLQELGGEEARRVS 721
            .:....:::|::.|..|..::.|..::|..::.:||:|.|.|..|::|...|.:.||........
Mouse   668 GIKNCPDSSDLHNNYAVFLVDSGFPEKAVAHYQQAIQLSPSHHVAVVNLGRLYRSLGENSKAEEW 732

  Fly   722 RSRLYKVLENDDQNEKVYFNLGMLAMDESSFDEAEQFFKRAIHLKADFRSALFNLALLLADTKRP 786
            ..|..||.    :..:|...||.|..:.....||.:.::.|:.|:...|.....||.:||...:.
Mouse   733 YRRALKVA----RTAEVLSPLGALYYNTGRHKEALEVYREAVSLQPSQRELRLALAQVLAVMGQT 793

  Fly   787 LDAVPFLNQLIRHHPSHVKGLILLGDIYI---NHMKDLDEAEKCYRSILHYDPHNTQGLHNLCVV 848
            .:|....:.::...|..::...||..|:.   :|.|.|:..||.    |...|.:.:.:..|...
Mouse   794 KEAEKITSHIVSEEPRCLECYRLLSAIHSKQEHHGKALEAIEKA----LQLKPKDPKVISELFFT 854

  Fly   849 ----FVERKRLAKAAACLQYAQRLAP--AEDYIG----RHLQ--IVLAR--LQKINKLPESAPER 899
                ..|:..|.||....:.|..|.|  |:.::.    ||:|  .|.||  .::..||   .|:.
Mouse   855 KGNQLREQNLLDKAFESYEAAVTLDPDQAQAWMNMGGIRHIQGSYVSARAYYERALKL---VPDS 916

  Fly   900 KLAYED---YDPLEFKLPQDR 917
            ||..|:   .|.||.:|.:.|
Mouse   917 KLLKENLAKLDRLERRLQEVR 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	DUF1736	323..396	CDD:369859	33/75 (44%)
		PEP_TPR_lipo	<513..871	CDD:274350	91/366 (25%)
		TPR repeat	514..542	CDD:276809	8/27 (30%)
		TPR repeat	547..591	CDD:276809	12/43 (28%)
		TPR repeat	598..625	CDD:276809	10/26 (38%)
		TPR repeat	630..660	CDD:276809	6/29 (21%)
		TPR repeat	665..693	CDD:276809	6/27 (22%)
		TPR repeat	737..764	CDD:276809	7/26 (27%)
		TPR repeat	803..834	CDD:276809	9/33 (27%)
		TPR repeat	839..867	CDD:276809	6/31 (19%)
Tmtc1	NP_945318.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..285		7/41 (17%)
		DUF1736	351..425	CDD:285594	33/76 (43%)
		TPR_11	542..605	CDD:290150	19/65 (29%)
		TPR 1	543..576		8/32 (25%)
		TPR_2	543..576	CDD:285020	8/32 (25%)
		TPR repeat	543..571	CDD:276809	8/27 (30%)
		TPR repeat	576..603	CDD:276809	9/29 (31%)
		TPR 2	577..607		12/46 (26%)
		TPR	577..607	CDD:197478	12/46 (26%)
		TPR_17	596..628	CDD:290167	14/46 (30%)
		TPR 3	608..641		11/33 (33%)
		TPR repeat	608..636	CDD:276809	10/28 (36%)
		TPR	621..940	CDD:223533	82/328 (25%)
		TPR 4	642..675		6/32 (19%)
		TPR repeat	642..670	CDD:276809	6/27 (22%)
		TPR repeat	675..705	CDD:276809	7/29 (24%)
		TPR 5	676..709		9/32 (28%)
		TPR 6	710..742		8/35 (23%)
		TPR repeat	710..738	CDD:276809	6/27 (22%)
		TPR_7	715..744	CDD:289919	7/32 (22%)
		TPR 7	743..776		8/32 (25%)
		TPR repeat	743..771	CDD:276809	7/27 (26%)
		TPR_14	749..786	CDD:290164	10/36 (28%)
		TPR repeat	776..806	CDD:276809	6/29 (21%)
		TPR 8	811..844		10/36 (28%)
		TPR repeat	812..839	CDD:276809	8/30 (27%)
		TPR repeat	844..878	CDD:276809	6/33 (18%)
		TPR 9	849..882		8/32 (25%)
		TPR 10	883..916		10/35 (29%)
		TPR_1	883..915	CDD:278916	9/34 (26%)
		TPR repeat	883..911	CDD:276809	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810