DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tmtc3 and sxc

DIOPT Version :9

Sequence 1:	NP_477246.2	Gene:	Tmtc3 / 37401	FlyBaseID:	FBgn0020312	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_523620.1	Gene:	sxc / 35486	FlyBaseID:	FBgn0261403	Length:	1059	Species:	Drosophila melanogaster

Alignment Length:	565	Identity:	135/565 - (23%)
Similarity:	231/565 - (40%)	Gaps:	109/565 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   424 PFLPASNLFFPVGFVVAER-ILYMPSMGYCLLV-----AYGFEQLQRRGSLSWQRFSQAALAILL 482
            |....|||      ||.:. |..:.|:|...|.     |..:|..::.....|::.| ....:||
  Fly    31 PNSTGSNL------VVKQNDIQSLSSVGLLELAHREYQAVDYESAEKHCMQLWRQDS-TNTGVLL 88

  Fly   483 LTHALKTHQRNLDWRTEYSLFMSGVHVNQRNAKLYNNVGHALENEGKFEEALLYFQQAVRIQTDD 547
            |..::....|.||...::|..  .:..|...|:.|:|:|:..:..|:.:|||..:::|||::.|.
  Fly    89 LLSSIHFQCRRLDKSAQFSTL--AIKQNPVLAEAYSNLGNVFKERGQLQEALDNYRRAVRLKPDF 151

  Fly   548 IGAHINVGRTFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLANLIAKNQTR 612
            |..:||:.......:....|.|||:.|          :.|:    |:...|..:|.||: |...|
  Fly   152 IDGYINLAAALVAARDMESAVQAYITA----------LQYN----PDLYCVRSDLGNLL-KALGR 201

  Fly   613 LEEAD----------------------------------HLYRQAISMRSDYVQAYINRGDILMK 643
            ||||.                                  |.:.:|:::..:::.||||.|::|.:
  Fly   202 LEEAKACYLKAIETCPGFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKE 266

  Fly   644 LNRTAQAQEVYEQALLYDNENADIYYNLGVVFLEQGKSQQAQVYFNKAIELYPEHEQALLNSAIL 708
            .....:|...|.:||.....||.::.||..|:.|||....|...:.:||||.|....|..|.|..
  Fly   267 ARIFDRAVAAYLRALNLSPNNAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPNFPDAYCNLANA 331

  Fly   709 LQELGGEEARRVSRSRLYKVLEN--DDQNEKVYFNLGMLAMDESSFDEAEQFFKRAIHLKADFRS 771
            |:|.|..:......:...::..|  |..|     ||..:..::...:||.:.:.:|:.:..||.:
  Fly   332 LKEKGQVKEAEDCYNTALRLCSNHADSLN-----NLANIKREQGYIEEATRLYLKALEVFPDFAA 391

  Fly   772 ALFNLALLLADTKRPLDAVPFLNQLIRHHPSHVKGLILLGDIYINHMKDLDEAEKCYRSILHYDP 836
            |..|||.:|....:..:|:....:.||..|:.......:|:. :..::|:..|.:||...:..:|
  Fly   392 AHSNLASVLQQQGKLKEALMHYKEAIRIQPTFADAYSNMGNT-LKELQDVSGALQCYTRAIQINP 455

  Fly   837 HNTQGLHNLCVVFVERKRLAKAAACLQYAQRLAPAEDY------IGRHLQIVL------ARLQKI 889
            .......||..:..:...:.:|....:.|.:|.|  |:      :...||||.      .|::|:
  Fly   456 AFADAHSNLASIHKDSGNIPEAIQSYRTALKLKP--DFPDAYCNLAHCLQIVCDWTDYDIRMKKL 518

  Fly   890 ----------NKLPESAPERKLAYEDYDPLEFKLPQDRPTHKSRK 924
                      |:||...|...:.|    ||         ||..||
  Fly   519 VSIVTEQLEKNRLPSVHPHHSMLY----PL---------THDCRK 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	DUF1736	323..396	CDD:369859
		PEP_TPR_lipo	<513..871	CDD:274350	94/393 (24%)
		TPR repeat	514..542	CDD:276809	9/27 (33%)
		TPR repeat	547..591	CDD:276809	9/43 (21%)
		TPR repeat	598..625	CDD:276809	12/60 (20%)
		TPR repeat	630..660	CDD:276809	10/29 (34%)
		TPR repeat	665..693	CDD:276809	9/27 (33%)
		TPR repeat	737..764	CDD:276809	5/26 (19%)
		TPR repeat	803..834	CDD:276809	5/30 (17%)
		TPR repeat	839..867	CDD:276809	4/27 (15%)
sxc	NP_523620.1	TPR repeat	53..78	CDD:276809	3/24 (13%)
		TPR_11	86..149	CDD:290150	19/64 (30%)
		TPR repeat	86..112	CDD:276809	7/27 (26%)
		TPR_11	118..183	CDD:290150	21/78 (27%)
		TPR_1	118..151	CDD:278916	11/32 (34%)
		TPR repeat	118..146	CDD:276809	9/27 (33%)
		TPR repeat	151..181	CDD:276809	8/39 (21%)
		TPR_12	182..252	CDD:290160	13/74 (18%)
		TPR_1	192..219	CDD:278916	9/27 (33%)
		TPR_1	220..253	CDD:278916	2/32 (6%)
		TPR repeat	220..248	CDD:276809	2/27 (7%)
		TPR	233..490	CDD:223533	63/264 (24%)
		TPR_1	255..287	CDD:278916	10/31 (32%)
		TPR repeat	255..282	CDD:276809	9/26 (35%)
		TPR repeat	287..317	CDD:276809	11/29 (38%)
		TPR_1	288..321	CDD:278916	13/32 (41%)
		TPR_17	310..342	CDD:290167	11/31 (35%)
		TPR repeat	322..350	CDD:276809	6/27 (22%)
		TPR repeat	355..385	CDD:276809	7/34 (21%)
		TPR_10	356..>385	CDD:290111	7/33 (21%)
		TPR_1	390..423	CDD:278916	9/32 (28%)
		TPR repeat	390..418	CDD:276809	6/27 (22%)
		TPR repeat	423..453	CDD:276809	5/30 (17%)
		TPR_1	424..455	CDD:278916	5/31 (16%)
		TPR_1	458..491	CDD:278916	6/34 (18%)
		TPR repeat	458..486	CDD:276809	4/27 (15%)
		Glyco_transf_41	584..1044	CDD:290556
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467057
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840