Protein Alignment Tmtc3 and IFIT1

DIOPT Version :10

• Sequence 1: NP_477246.2
• Gene: Tmtc3 / 37401
• FlyBaseID: FBgn0020312
• Length: 926
• Species: Drosophila melanogaster
• Sequence 2: NP_001539.3
• Gene: IFIT1 / 3434
• HGNCID: 5407
• Length: 478
• Species: Homo sapiens
• Alignment Length: 404
• Identity: 77/404 - (19%)
• Similarity: 153/404 - (37%)
• Gaps: 119/404 - (29%)

  Fly   400 AKTCFTRNLALSRTLIMCLGWMVLPFLPASNLFFPV------GFVVA-------------ERILY 445
            ||.||.:.|.:.            |..|.|:..:.:      ||.:|             :.:..
Human   160 AKACFEKVLEVD------------PENPESSAGYAISAYRLDGFKLATKNHKPFSLLPLRQAVRL 212

  Fly   446 MPSMGYC-LLVAYGFEQLQRRG-SLSWQRFSQAALAILLLTHALKTHQRNLDWRTEYSLFMSGVH 508
            .|..||. :|:|.   :||..| ....:::.:.|||             |:..:|         :
Human   213 NPDNGYIKVLLAL---KLQDEGQEAEGEKYIEEALA-------------NMSSQT---------Y 252

  Fly   509 VNQRNAKLYNNVGHALENEGKFEEALLYFQQAVRIQTDDIGAHINVGRTFNNLKRYAEAEQAYVQ 573
            |.:..||.|       ..:|..::||...::|::.....:..|..:|..:
Human   253 VFRYAAKFY-------RRKGSVDKALELLKKALQETPTSVLLHHQIGLCY--------------- 295

  Fly   574 AKALFPQAKPGVSYHARIAPNHLNVFINLANLIAKNQTRLEE----ADHLYRQAISMRSDYVQAY 634
             ||...|.|.......|                .:|:.:|::    |...:..|:..:..:..|:
Human   296 -KAQMIQIKEATKGQPR----------------GQNREKLDKMIRSAIFHFESAVEKKPTFEVAH 343

  Fly   635 INRGDILMKLNRTAQAQEVYEQAL----LYDNENADIYYNLGVVFLEQGKSQ-QAQVYFNKAIEL 694
            ::...:.::.....:|:|.:::.|    :.:....||:::.|.....|.||. .|.:::.|||::
Human   344 LDLARMYIEAGNHRKAEENFQKLLCMKPVVEETMQDIHFHYGRFQEFQKKSDVNAIIHYLKAIKI 408

  Fly   695 YPEHEQALLNSAILLQELGGEEARRVSRSRLYKVLENDDQNEKVYFNLGMLAMDESSFDEAEQFF 759
                |||.|.....:..|.....|::.|    |.|:.:..:     .||.:...|.:.:||.:::
Human   409 ----EQASLTRDKSINSLKKLVLRKLRR----KALDLESLS-----LLGFVYKLEGNMNEALEYY 460

  Fly   760 KRAIHLKADFRSAL 773
            :||:.|.|||.:::
Human   461 ERALRLAADFENSV 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	TMTC_DUF1736	323..396	CDD:462468
		TPR	507..762	CDD:440225	47/263 (18%)
		TPR repeat	514..542	CDD:276809	7/27 (26%)
		TPR repeat	547..591	CDD:276809	6/43 (14%)
		TPR repeat	598..625	CDD:276809	4/30 (13%)
		TPR repeat	630..660	CDD:276809	4/33 (12%)
		LapB	634..896	CDD:442196	33/145 (23%)
		TPR repeat	665..693	CDD:276809	9/28 (32%)
		TPR repeat	737..764	CDD:276809	7/26 (27%)
		TPR repeat	803..834	CDD:276809
		TPR repeat	839..867	CDD:276809
IFIT1	NP_001539.3	TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	52..85
		TPR repeat	54..80	CDD:276809
		TPR	55..>245	CDD:440225	20/99 (20%)
		TPR 2. /evidence=ECO:0000255	95..128
		TPR repeat	97..123	CDD:276809
		TPR repeat	128..170	CDD:276809	5/9 (56%)
		TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	141..174		6/25 (24%)
		LapB	156..465	CDD:442196	73/393 (19%)
		TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	183..216		4/32 (13%)
		TPR repeat	216..246	CDD:276809	10/45 (22%)
		TPR 5. /evidence=ECO:0000255	218..249		10/46 (22%)
		TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	251..284		9/48 (19%)
		TPR repeat	252..279	CDD:276809	8/33 (24%)
		TPR repeat	284..335	CDD:276809	11/82 (13%)
		TPR 7. /evidence=ECO:0000255	305..339		5/49 (10%)
		TPR 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	340..373		4/32 (13%)
		TPR repeat	340..367	CDD:276809	3/26 (12%)
		TPR 9. /evidence=ECO:0000255	378..412		12/37 (32%)
		TPR repeat	378..407	CDD:276809	9/28 (32%)
		TPR 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	437..470		9/37 (24%)
		TPR repeat	437..465	CDD:276809	7/32 (22%)