DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tmtc3 and IFIT2

DIOPT Version :9

Sequence 1:NP_477246.2 Gene:Tmtc3 / 37401 FlyBaseID:FBgn0020312 Length:926 Species:Drosophila melanogaster
Sequence 2:NP_001538.4 Gene:IFIT2 / 3433 HGNCID:5409 Length:472 Species:Homo sapiens


Alignment Length:399 Identity:79/399 - (19%)
Similarity:136/399 - (34%) Gaps:115/399 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   597 NVFINLANLIAKNQTRLE---EADHLYRQ----AISMRS-----DYVQAYINRG---DILMKLNR 646
            |:...|.:|..:|:..||   :|:.|.:|    ...:||     :|...|.:.|   |:.:.:::
Human    55 NLLAYLKHLKGQNEAALECLRKAEELIQQEHADQAEIRSLVTWGNYAWVYYHMGRLSDVQIYVDK 119

  Fly   647 TAQAQEVYEQALLYDNENADIYYNLGVVFLEQG--KSQQAQVYFNKAIELYPEHEQALLNSAILL 709
            .....|.:...  |..|:.::....|...|:.|  ::::|:|.|.||:|..|::.:.....||..
Human   120 VKHVCEKFSSP--YRIESPELDCEEGWTRLKCGGNQNERAKVCFEKALEKKPKNPEFTSGLAIAS 182

  Fly   710 QELGG--------EEARRVSRSRLYKVLENDDQNEKVYFNLGMLAMDESSFD--EAEQFFKRAIH 764
            ..|..        :..|:..|      |..|:|..||...|.:..|.|...:  |.|:..:.|:.
Human   183 YRLDNWPPSQNAIDPLRQAIR------LNPDNQYLKVLLALKLHKMREEGEEEGEGEKLVEEALE 241

  Fly   765 LKADFRSALFNLALLLADTKRPLDAVPFLNQLIRHHPSHV------------------------- 804
            ........|.:.|........|..|:..|.:.:.:.|::.                         
Human   242 KAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNNAYLHCQIGCCYRAKVFQVMNLRENGM 306

  Fly   805 ----KGLILLGDIYINHMKDLDEAEKCYRSILHYDPHNTQGLHNLCVVFVERKRLAKAAACLQYA 865
                |.|.|:|.. :.|:|..|||              ...|..:|.:......||.     ||.
Human   307 YGKRKLLELIGHA-VAHLKKADEA--------------NDNLFRVCSILASLHALAD-----QYE 351

  Fly   866 QRLAPAEDYIGRHLQIVLARLQKINKLPESAPERK----LAYEDYDPLEFKLPQDRPTH------ 920
            .    ||.|..:...            .|..|..|    |.|.::...:.|. :|:..|      
Human   352 D----AEYYFQKEFS------------KELTPVAKQLLHLRYGNFQLYQMKC-EDKAIHHFIEGV 399

  Fly   921 ----KSRKR 925
                |||::
Human   400 KINQKSREK 408

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tmtc3NP_477246.2 DUF1736 323..396 CDD:369859
PEP_TPR_lipo <513..871 CDD:274350 65/329 (20%)
TPR repeat 514..542 CDD:276809
TPR repeat 547..591 CDD:276809
TPR repeat 598..625 CDD:276809 8/33 (24%)
TPR repeat 630..660 CDD:276809 5/32 (16%)
TPR repeat 665..693 CDD:276809 8/29 (28%)
TPR repeat 737..764 CDD:276809 8/28 (29%)
TPR repeat 803..834 CDD:276809 9/59 (15%)
TPR repeat 839..867 CDD:276809 6/27 (22%)
IFIT2NP_001538.4 TPR_12 51..112 CDD:290160 14/56 (25%)
TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339, ECO:0000269|PubMed:22825553 51..89 9/33 (27%)
TPR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339, ECO:0000269|PubMed:22825553 90..135 8/46 (17%)
TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339, ECO:0000269|PubMed:22825553 136..171 10/34 (29%)
TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339, ECO:0000269|PubMed:22825553 172..208 6/41 (15%)
TPR repeat 208..236 CDD:276809 8/27 (30%)
TPR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339, ECO:0000269|PubMed:22825553 247..280 6/32 (19%)
TPR repeat 248..275 CDD:276809 5/26 (19%)
TPR repeat 280..329 CDD:276809 7/49 (14%)
TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339, ECO:0000269|PubMed:22825553 281..335 10/68 (15%)
TPR repeat 334..359 CDD:276809 8/33 (24%)
TPR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339, ECO:0000269|PubMed:22825553 336..366 9/50 (18%)
TPR 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339, ECO:0000269|PubMed:22825553 367..405 7/38 (18%)
TPR 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339, ECO:0000269|PubMed:22825553 406..448 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 446..472
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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