DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tmtc3 and CG31690

DIOPT Version :9

Sequence 1:	NP_477246.2	Gene:	Tmtc3 / 37401	FlyBaseID:	FBgn0020312	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster

Alignment Length:	968	Identity:	282/968 - (29%)
Similarity:	388/968 - (40%)	Gaps:	257/968 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 CICVACIVCYYNSTQCGLVFDDISAIRDNKDLRPHTPLINVFLNDFWGTPMRKEQSHKSYRPLTV 103
            |..:| .|.|.|:...|.|:||..||..|.|:....||.|:..|||||||:....||.|:|||.|
  Fly    26 CSALA-FVLYLNTLNAGFVYDDRRAILANGDVTGARPLANLLRNDFWGTPLVDSGSHGSWRPLCV 89

  Fly   104 LTFRFNYLLHALEPFGYHLVNLLLHLSVCLLWRRVCRLLLRQCAASGSNAISAPSSSSVSQLNTC 168
            |:||.|||...:.|.||||||::||.....|...|.|.||             ||...|
  Fly    90 LSFRLNYLAGGMTPLGYHLVNVMLHCVATWLVFLVARTLL-------------PSRMGV------ 135

  Fly   169 AFVASLLFAVHPVHTEAVTGVVGRAELLSSICFLAAFLSYAKSVGDSGCPRRTNW----LTLFGC 229
             ..|..||||||.|||||.|:||||:|.|.:|:|.|:|||.:.:      ....|    ||:.
  Fly   136 -LAAGALFAVHPAHTEAVAGLVGRADLASCVCYLLAYLSYRRHM------LNREWGSLILTIM-- 191

  Fly   230 FGSCLLASMLCKEQGIT---IAGICVVYELFVVHQLRPLHLCHFVLRLFDERTEQQSPKLANP-- 289
               ..||::||||..||   :.|:|.|        |.|:             ..:.|.|:.:.
  Fly   192 ---LALAALLCKETAITALLLCGLCDV--------LSPV-------------GRENSDKVCDGSI 232

  Fly   290 SGIRRWSSSTLWKRLSFLVGITLTLLVGRVYVMGSQLPIFTRFDNPASAADTP--------ERQL 346
            ||:..::....::.||.|   ..|||.| :|...|.||   |.....||||.|        .|.|
  Fly   233 SGLASFNFQRRFRSLSIL---GFTLLCG-LYCRLSLLP---RPSTAFSAADNPTAHESCFWTRTL 290

  Fly   347 TYGYLIYLNCWLLLCPSLLCCDWTMGTVPLLQGFTDSRNITTLLTFLALGAMVAKTCFTRNLA-- 409
            |:.||...|..:||.|..|..||.|..|..::...|:|||.|...:.:|.|::.|....|:.|
  Fly   291 TFLYLPVANFGILLWPQELSFDWGMEAVSRIRTLWDARNILTAGFYGSLVAILWKGSGLRSAASP 355

  Fly   410 --------LSRTLIMCLG----------------------------------------W------ 420
                    :|..|:..||                                        |
  Fly   356 MDFAEVANISLPLLRRLGGNSCHTWLGLTCDCHHQLSAPSYRSASAIYSTSSKSKSASWTAAPIL 420

  Fly   421 ----MVLPFLPASNLFFPVGFVVAERILYMPSMGYCLLVAYGFEQLQRRGSLSWQR--FSQAALA 479
                :||||||||||.|.||||:|||:||:||:|||||...||..|.:|.:.||:.  .....||
  Fly   421 GTAFLVLPFLPASNLLFYVGFVMAERVLYLPSVGYCLLFGLGFGHLWQRVNSSWRSRLMLLCGLA 485

  Fly   480 ILLLTHALKTHQRNLDWRTEYSLFMSGVHVNQRNAKLYNNVGHALENEGKFEEALLYFQQAVRIQ 544
            :||..|.::|.:||||||.|..||.|.:.:|.  .|...|:|..|..:|::|||.|..:..:..:
  Fly   486 LLLGVHGVRTFRRNLDWRDEEQLFRSAISINP--PKALGNLGSVLSAQGRYEEAELTLRMTLGHR 548

  Fly   545 TDDIGAHINVGRTFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLANLIAKN 609
            .....||.|:|                                                 ::.:.
  Fly   549 PTMADAHFNLG-------------------------------------------------VVHQK 564

  Fly   610 QTRLEEADHLYRQAISMRSDYVQAYINRGDILMKL-NRTAQAQEVYEQALLYDNENA-------- 665
            |.....|...:|:||.:|.....||:|.|..|:.| :...:|..|.......:....
  Fly   565 QLNFSSAIPCFRRAIELRPQLAVAYLNLGTSLISLGDHRQEAISVLRTGARLEGSGVRDRGAHVE 629

  Fly   666 ---DIYYNLGVVFLEQGKSQQAQVYFN---KAIELYPEHEQALLNSAI--LLQEL-GGEEARRVS 721
               ..|..|.|::...|:.|.|.....   ||:.|.|:.::|:|:..:  :|.|| ...||....
  Fly   630 ARYTCYLQLSVLYRSDGRLQDAAAALRESLKALPLLPQKQRAVLHLRLGEILAELQDWNEAEHQQ 694

  Fly   722 RSRLYKVLENDDQNEKVYFNLGM-LAMDESSFDEAEQFFKRAIHLKADFRSALFNLALLLADTKR 785
            |    ..::...:....|...|. ||.:.|...|||.:||||:.|                   .
  Fly   695 R----LAMQLQPEQGAAYVTYGQTLARNGSRLAEAESWFKRALQL-------------------A 736

  Fly   786 PLDA------VPFLNQLIRHHPS---HVKGLILLGDIY---------INHMKDLDEAEKCYRSIL 832
            ||:.      ..||.|..|||.:   .::...|....|         :..:..|.|||..||..:
  Fly   737 PLEPSSHHHYADFLEQQERHHEALGLRLRAAALAPQDYTLQSCVADALRLLNRLAEAELWYRKAV 801

  Fly   833 HYDPHNTQGLHNLCVVFVERKRLAKAAACLQYAQRLAPAEDYIGRHLQIVLARLQKIN 890
            ...|.......||..:...|....:|.||...|..|.|..       .|..|.|.::|
  Fly   802 TLQPMAAHAHANLGAILQMRGLRKEAVACYHKALELQPGH-------AISRANLARMN 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	DUF1736	323..396	CDD:369859	28/80 (35%)
		PEP_TPR_lipo	<513..871	CDD:274350	83/394 (21%)
		TPR repeat	514..542	CDD:276809	9/27 (33%)
		TPR repeat	547..591	CDD:276809	4/43 (9%)
		TPR repeat	598..625	CDD:276809	4/26 (15%)
		TPR repeat	630..660	CDD:276809	8/30 (27%)
		TPR repeat	665..693	CDD:276809	8/41 (20%)
		TPR repeat	737..764	CDD:276809	12/27 (44%)
		TPR repeat	803..834	CDD:276809	8/39 (21%)
		TPR repeat	839..867	CDD:276809	7/27 (26%)
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594	24/67 (36%)
		TPR_11	518..583	CDD:290150	18/113 (16%)
		TPR repeat	518..546	CDD:276809	9/27 (33%)
		TPR repeat	551..581	CDD:276809	9/78 (12%)
		TPR_1	552..584	CDD:278916	10/80 (13%)
		TPR	565..841	CDD:223533	71/298 (24%)
		TPR repeat	586..611	CDD:276809	8/24 (33%)
		TPR repeat	634..660	CDD:276809	6/25 (24%)
		TPR repeat	671..699	CDD:276809	8/31 (26%)
		TPR repeat	704..735	CDD:276809	12/30 (40%)
		TPR repeat	740..768	CDD:276809	6/27 (22%)
		TPR repeat	773..803	CDD:276809	7/29 (24%)
		TPR	808..841	CDD:197478	9/32 (28%)
		TPR repeat	808..836	CDD:276809	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467044
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.750