DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tmtc3 and Tmtc2

DIOPT Version :10

Sequence 1:NP_477246.2 Gene:Tmtc3 / 37401 FlyBaseID:FBgn0020312 Length:926 Species:Drosophila melanogaster
Sequence 2:NP_608558.1 Gene:Tmtc2 / 33276 FlyBaseID:FBgn0028481 Length:938 Species:Drosophila melanogaster


Alignment Length:1046 Identity:279/1046 - (26%)
Similarity:404/1046 - (38%) Gaps:334/1046 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 LEFLCI--CVACIVCYYNSTQCGLVFDDISAIRDNKDLRPHTPLINVFLNDFWGTPMRKEQSHKS 97
            ::|.|:  |....|.|.|:...|.|:||..||..|.|:...||....|.|||||||:....||.|
  Fly    31 MDFTCLFCCSLAFVLYLNTLGAGFVYDDRRAILANADVSGGTPWQRSFSNDFWGTPLTDSGSHGS 95

  Fly    98 YRPLTVLTFRFNYLL-HALEPFGYHLVNLLLHLSVCLLWRRVCRLLLRQCAASGSNAISAPSSSS 161
            :|||.||:||.|||: ....|:|:||||.|||.....|..||.|.||....|             
  Fly    96 WRPLCVLSFRLNYLIGGGFAPWGFHLVNNLLHCVATALVVRVARTLLASVWA------------- 147

  Fly   162 VSQLNTCAFVASLLFAVHPVHTEAVTGVVGRAELLSSICFLAAFLSYAKSV--GDSGCPRRTNWL 224
                   ...|..|||.||:|||||.||||||:|.:.:|:|..:|||.:.:  .:||.||:  ||
  Fly   148 -------VLAAGALFAAHPIHTEAVAGVVGRADLAACVCYLLTYLSYLRHMRWRESGDPRQ--WL 203

  Fly   225 TLFGCFGSCLL---ASMLCKEQGITIAGICVVYELFVVHQLRPLHLCHFVLRLFDERTEQQSPKL 286
            .|    |:.|:   |.:||||..||...:|.:::               |:|....:.::|.   
  Fly   204 AL----GATLILAAAGLLCKETAITALLVCALFD---------------VMRGLSGQVDKQR--- 246

  Fly   287 ANPSGIRRWSSSTLWKRLSFLVGITLTLLVGRVYVMGSQLPIFTRFDNPASAADTPE---RQLTY 348
                          .:.:..::|....:...|:.::......|:..|||  .|.||.   |.||:
  Fly   247 --------------LRSVCIVLGALFCMAYCRLVIVPGPQTAFSSADNP--IARTPSAWTRLLTF 295

  Fly   349 GYLIYLNCWLLLCPSLLCCDWTMGTVPLLQGFTDSRN-----ITTLLTFLALGAM---------- 398
            .||...|..|||.|::|..||.|..:|.:....|.||     ..::|..:|.|:.          
  Fly   296 LYLPVFNLRLLLQPNVLSFDWGMDALPRVTSLWDRRNAQSACFYSVLVGVAWGSCRQLLSGSKEV 360

  Fly   399 ----VAKT--------------------------------------------------------- 402
                |:.|                                                         
  Fly   361 THCGVSSTFPQYHIQKVASRKSRSKRKRLANNTKYQAFEAAYHQQQQEALPCRDCNNNNSSGYVY 425

  Fly   403 -----------------------------------------------------------CFTRNL 408
                                                                       |.:::.
  Fly   426 EGSSPVAQAPAQAPHLVSSAFRGSRSSSSCSNSTNSSSSSSSSSSSSSSSSSSLSGGFQCSSKDY 490

  Fly   409 AL---------SRTLIMCLGWMVLPFLPASNLFFPVGFVVAERILYMPSMGYCLLVAYGFEQL-- 462
            ||         :..|||.|.::.|||||||||.|.||||||||:||:||:|:||||.||..:|  
  Fly   491 ALEGMSPANRHACVLIMSLSFLALPFLPASNLLFYVGFVVAERLLYLPSVGFCLLVGYGVSKLMS 555

  Fly   463 --QRRGSLSWQRFSQAALAILLLTHALKTHQRNLDWRTEYSLFMSGVHVNQRNAKLYNNVGHALE 525
              ||..::....||     :||...:|:|.:||.|||.|.||:.|.:.:|.  .|...|:|..|.
  Fly   556 CNQRTRNILLLSFS-----LLLAAMSLRTLRRNADWRDEESLYRSAIAINP--PKALGNLGSVLS 613

  Fly   526 NEGKFEEALLYFQQAVRIQTDDIGAHINVGRTFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHAR 590
            ::|::|||....|:|:|.:.:....|.|:|                                   
  Fly   614 SQGRYEEAKQVLQEAIRFRPNMADVHFNLG----------------------------------- 643

  Fly   591 IAPNHLNVFINLANLIAKNQTRLEEADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEVYE 655
                          ::.:||.....|...:::||..|.:...||:|.|...:.|.:..||.|:.:
  Fly   644 --------------ILHQNQQVYPAAVECFQRAIKFRPNLAVAYLNLGISFIALGKRQQAIEILQ 694

  Fly   656 -----------QALLYDNENADIYYNLGVVFLEQGKSQQAQVYFNKAIELYPEHEQALLNSAILL 709
                       ....:|...:..|..||.:::||||.|:|...:.:|:...|...|   ...||.
  Fly   695 AGSNLDGAAVRDRTAHDQARSSAYLQLGALYVEQGKLQRALAIYREALSSLPGLPQ---QREILY 756

  Fly   710 QELGG--------EEARRVSRSRLYKVLENDDQNEKVYFNLGM-LAMDESSFDEAEQFFKRAIHL 765
            |.:|.        :||.|..|:    .||........:.:.|: ||.:.|...|||.:||||:.|
  Fly   757 QRIGDVLGRLQQWDEAERHHRA----ALELQPNQVAAHLSYGITLARNSSRASEAEMWFKRALKL 817

  Fly   766 KADFRSALFNLALLLADTKRPLDAVPFLNQLIRHHPS---HVKGLILLGDIY------INHMKDL 821
            ..:..|...:.|             .||:...|||.|   |.:...|..:.|      ...|:.|
  Fly   818 APEQASVYHHYA-------------EFLSLQSRHHESAIYHRRAAELAPNDYTLVVAAATAMRLL 869

  Fly   822 D---EAEKCYRSILHYDPHNTQGLHNLCVVFVERKRLAKAAACLQYAQRLAPAEDYIGRHLQIVL 883
            |   :||..||..:...|.:.....||..:.....|...|||..:.|.||.|.:       .|.|
  Fly   870 DRKVDAEMWYRKAVALRPGDAHAHTNLGAILHLLGRTNHAAASYKAALRLQPGD-------AITL 927

  Fly   884 ARLQKI 889
            ..|.|:
  Fly   928 GNLAKL 933

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tmtc3NP_477246.2 TMTC_DUF1736 323..396 CDD:462468 27/80 (34%)
TPR 507..762 CDD:440225 61/274 (22%)
TPR repeat 514..542 CDD:276809 10/27 (37%)
TPR repeat 547..591 CDD:276809 3/43 (7%)
TPR repeat 598..625 CDD:276809 4/26 (15%)
TPR repeat 630..660 CDD:276809 8/40 (20%)
LapB 634..896 CDD:442196 75/288 (26%)
TPR repeat 665..693 CDD:276809 10/27 (37%)
TPR repeat 737..764 CDD:276809 11/27 (41%)
TPR repeat 803..834 CDD:276809 10/39 (26%)
TPR repeat 839..867 CDD:276809 7/27 (26%)
Tmtc2NP_608558.1 TMTC_DUF1736 270..343 CDD:462468 25/74 (34%)
TPR 597..852 CDD:440225 73/325 (22%)
TPR repeat 602..630 CDD:276809 10/27 (37%)
TPR repeat 635..665 CDD:276809 8/78 (10%)
TPR repeat 670..694 CDD:276809 8/23 (35%)
TPR repeat 715..743 CDD:276809 10/27 (37%)
TPR repeat 748..782 CDD:276809 10/40 (25%)
TPR 780..>933 CDD:440225 46/172 (27%)
TPR repeat 787..816 CDD:276809 11/28 (39%)
TPR repeat 822..850 CDD:276809 9/40 (23%)
TPR repeat 855..885 CDD:276809 8/29 (28%)
TPR repeat 890..918 CDD:276809 7/27 (26%)

Return to query results.
Submit another query.