DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tmtc3 and ifit15

DIOPT Version :9

Sequence 1:	NP_477246.2	Gene:	Tmtc3 / 37401	FlyBaseID:	FBgn0020312	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_001288040.1	Gene:	ifit15 / 322336	ZFINID:	ZDB-GENE-030131-1055	Length:	429	Species:	Danio rerio

Alignment Length:	455	Identity:	82/455 - (18%)
Similarity:	153/455 - (33%)	Gaps:	149/455 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   517 YNNVGHALENEGKFEEALLYFQQAVRIQTDDIGAHINVGRTFNNLKRYAEAEQAYVQAKALFPQA 581
            ||.:|...::.|...|||...|:|                            ::.:|.:.....|
Zfish    49 YNLLGFIQKSLGSDREALESLQKA----------------------------ESVIQEQGTEETA 85

  Fly   582 KPGVSYHARIAPNHLNVFINLANL---------IAKNQTRLEEADHLYRQAISMRSDYVQAYIN- 636
                          :.:.:|.||:         :.|::..|||.:.|.|...:.....:...::
Zfish    86 --------------VRLLVNKANMAWVHFHLGELEKSRGYLEELEELQRIHPAPPGCPLHPEVSG 136

  Fly   637 -RGDILMKLNRTAQ--AQEVYEQALLYDNENADIYYNLGV------VFLEQGKSQQAQVY--FNK 690
             :|..|:|.|::.:  |.:.::.||..:.|..:.:..|.:      ::.:....|:|::.  ...
Zfish   137 EKGWTLVKFNKSKKRLAIDYFKMALEAEPERKEWHKGLAISMSKACLWYKCTPEQKAEILEKVKT 201

  Fly   691 AIELYPEHEQALLNSAILLQELG---GEEARRVSRSRLYKVLE--NDDQNEKVYFNLGMLAMDES 750
            |.|:.|..   ||..|:.|.:|.   .....|..|..|.:.||  |......:...||.::.||
Zfish   202 AAEINPND---LLLQALYLVKLSYVTKVNVEREMRDLLERCLEIVNVPGLNIILKYLGDISFDE- 262

  Fly   751 SFDEAEQFFKRAIHLKADFRSALFNLALLLADTKRPLDAVPFLNQLIRHHPSHVKGLILLGDIY- 814
            |..|.|:|.:|                                      :|..:|.|..|.|.|
Zfish   263 SIREGERFQER--------------------------------------YPESIKVLKCLADTYK 289

  Fly   815 --------------INHMKDLDEAEK-C------YR-----SILHYDPHNTQGLHNLCVVFVERK 853
                          |...|.::..|| |      :|     :.:||..|||:....:....:..:
Zfish   290 WKVYKMNEDTEERVILARKTIELLEKVCGYNPDSHRAKVALAAMHYYAHNTERADEIYQQLLLEE 354

  Fly   854 RLAK---------AAACLQYAQRLAPAEDYIGRHLQIVLARLQKINKLPESAPERKLAYEDYDPL 909
            .|:.         .|:.|...:|.:.:..:   |::.|......::|.......:|:.:...|||
Zfish   355 ELSPDKWQYIYYCYASYLNQCKRFSESVQF---HIKGVKTPGDSVDKEKSLNILKKIVWRGKDPL 416

Fly 910 909
Zfish 417 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	DUF1736	323..396	CDD:369859
		PEP_TPR_lipo	<513..871	CDD:274350	75/415 (18%)
		TPR repeat	514..542	CDD:276809	9/24 (38%)
		TPR repeat	547..591	CDD:276809	2/43 (5%)
		TPR repeat	598..625	CDD:276809	9/35 (26%)
		TPR repeat	630..660	CDD:276809	7/33 (21%)
		TPR repeat	665..693	CDD:276809	4/35 (11%)
		TPR repeat	737..764	CDD:276809	9/26 (35%)
		TPR repeat	803..834	CDD:276809	11/57 (19%)
		TPR repeat	839..867	CDD:276809	4/36 (11%)
ifit15	NP_001288040.1	TPR_11	<50..>368	CDD:330823	71/401 (18%)
		TPR repeat	323..356	CDD:276809	6/32 (19%)
		TPR repeat	361..390	CDD:276809	4/31 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900