Protein Alignment Tmtc3 and Tmtc3

DIOPT Version :10

• Sequence 1: NP_477246.2
• Gene: Tmtc3 / 37401
• FlyBaseID: FBgn0020312
• Length: 926
• Species: Drosophila melanogaster
• Sequence 2: NP_001129330.1
• Gene: Tmtc3 / 314785
• RGDID: 1306351
• Length: 920
• Species: Rattus norvegicus
• Alignment Length: 916
• Identity: 463/916 - (50%)
• Similarity: 593/916 - (64%)
• Gaps: 76/916 - (8%)

  Fly    33 NLLEFLCICVACIVCYYNSTQCGLVFDDISAIRDNKDLRPHTPLINVFLNDFWGTPMRKEQSHKS 97
            |..|...|......||:||..||.||||:|||.|||||.|.|||..:|.||||||||.:|:||||
  Rat    10 NFKEVTLIVGVVAACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEERSHKS 74

  Fly    98 YRPLTVLTFRFNYLLHALEPFGYHLVNLLLHLSVCLLWRRVCRLLLRQCAASGSNAISAPSSSSV 162
            ||||||||||.||||..|:|..|||:|.:.|..|.:::.:||||.|.:   .||
  Rat    75 YRPLTVLTFRLNYLLSELKPMSYHLLNTVFHAVVSVIFLKVCRLFLDK---RGS----------- 125

  Fly   163 SQLNTCAFVASLLFAVHPVHTEAVTGVVGRAELLSSICFLAAFLSYAKSVG-DSGCPRRTNWLTL 226
                   .:|:|||||||:|||||||||||||||||:.||||||||.||.| |:........||:
  Rat   126 -------VIAALLFAVHPIHTEAVTGVVGRAELLSSVFFLAAFLSYTKSKGPDNSIVWTPIALTV 183

  Fly   227 FGCFGSCLLASMLCKEQGITIAGICVVYELFVVHQLRPLHLCHFVLRLFDERTEQQSPKLANPSG 291
            .     .:..:.||||||||:.|||.|||:||........||                  |....
  Rat   184 L-----LVAVATLCKEQGITVVGICCVYEVFVAQGYTLPLLC------------------AVAGQ 225

  Fly   292 IRRWSSSTLWKRLSFLVGI------TLTLLVGRVYVMGSQLPIFTRFDNPASAADTPERQLTYGY 350
            ..|...|..:..|..|:.:      ||.|:|.||.|:.||||:||||||||:.:.||.||||:.|
  Rat   226 FLRGKGSIPFSMLQTLIKLIVLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPTPTRQLTFNY 290

  Fly   351 LIYLNCWLLLCPSLLCCDWTMGTVPLLQGFTDSRNITTLLTFLALGAMVAKTCFTRNLA--LSRT 413
            |:.:|.||||.||.|||||||||:||::.|.|.||:.|...|..|||:   ..|:....  .|:|
  Rat   291 LLPVNAWLLLNPSELCCDWTMGTIPLIESFLDVRNLATFAFFCFLGAL---GIFSLRYPGDSSKT 352

  Fly   414 LIMCLGWMVLPFLPASNLFFPVGFVVAERILYMPSMGYCLLVAYGFEQLQRRGSLSWQRFSQAAL 478
            ::|.|..|.|||:||||||||||||||||:||:||||:|:|||:|::::..:..|  ::.|...|
  Rat   353 VLMALSLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISNKSVL--KKLSWVCL 415

  Fly   479 AILLLTHALKTHQRNLDWRTEYSLFMSGVHVNQRNAKLYNNVGHALENEGKFEEALLYFQQAVRI 543
            ::::|||||||..||.||.:||:||||.:.||:.||||:||||||||||..||:||.||.||..:
  Rat   416 SMVILTHALKTLHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFEKALKYFLQATHV 480

  Fly   544 QTDDIGAHINVGRTFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLANLIAK 608
            |.||||||:|||||:.||.|..|||::|:.||:|.||..||..|.||||||||||:|||||||..
  Rat   481 QPDDIGAHMNVGRTYKNLNRTKEAEESYMLAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRA 545

  Fly   609 NQTRLEEADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEVYEQALLYDNENADIYYNLGV 673
            |::||||||.|||||||||.|:.||||:||::|:|:|:..:|:|.|.:||..|..|||::|||.:
  Rat   546 NESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAI 610

  Fly   674 VFLEQGKSQQAQVYFNKAIELYPEHEQALLNSAILLQELGGEEARRVSRSRLYKVLENDDQNEKV 738
            |::|..:..:|...||:|:||...|:.||.|||||:||.|..:.|..:|.||...:..:.|:...
  Rat   611 VYIELKEPDEALKNFNRALELNSRHKLALFNSAILMQESGEVKLRPEARKRLLNYINEEPQDANG 675

  Fly   739 YFNLGMLAMDESSFDEAEQFFKRAIHLKADFRSALFNLALLLADTKRPLDAVPFLNQLIRHHPSH 803
            ||||||||||:....|||.:.||||.|:.||||||||||||.:.|.:.|.|:|.|.:|:|::|.|
  Rat   676 YFNLGMLAMDDKKDSEAETWMKRAIKLQPDFRSALFNLALLYSQTAKELKALPILEELLRYYPDH 740

  Fly   804 VKGLILLGDIYINHMKDLDEAEKCYRSILHYDPHNTQGLHNLCVVFVERKRLAKAAACLQYAQRL 868
            .|||||.|||.:|..||:..|:||:..||..||.|.||.||||||:.|.|.|.||..||.....|
  Rat   741 TKGLILKGDILMNQKKDIAGAKKCFEKILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLVETLAL 805

  Fly   869 APAEDYIGRHLQIVLAR----------LQKINKLPESAPERKLAYEDYDPLEFKLPQDRP----- 918
            ||.|:||.|||.||..:          |..::|...:..:.::..||...:   :.:.||
  Rat   806 APHEEYIQRHLSIVRDKIASSGIVDQPLSPVDKTSGTEEKDEVPSEDVKEI---ISESRPAQIIK 867

  Fly   919 THKSRK 924
            |:.:||
  Rat   868 TNDNRK 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	TMTC_DUF1736	323..396	CDD:462468	44/72 (61%)
		TPR	507..762	CDD:440225	144/254 (57%)
		TPR repeat	514..542	CDD:276809	21/27 (78%)
		TPR repeat	547..591	CDD:276809	26/43 (60%)
		TPR repeat	598..625	CDD:276809	20/26 (77%)
		TPR repeat	630..660	CDD:276809	14/29 (48%)
		LapB	634..896	CDD:442196	129/271 (48%)
		TPR repeat	665..693	CDD:276809	11/27 (41%)
		TPR repeat	737..764	CDD:276809	16/26 (62%)
		TPR repeat	803..834	CDD:276809	17/30 (57%)
		TPR repeat	839..867	CDD:276809	15/27 (56%)
Tmtc3	NP_001129330.1	Stt3	77..>375	CDD:440898	142/304 (47%)
		TMTC_DUF1736	263..336	CDD:462468	34/78 (44%)
		TPR	444..673	CDD:440225	134/228 (59%)
		TPR repeat	451..479	CDD:276809	15/27 (56%)
		TPR repeat	484..528	CDD:276809	29/43 (67%)
		TPR repeat	535..562	CDD:276809	13/26 (50%)
		LapB	549..804	CDD:442196	138/254 (54%)
		TPR repeat	567..597	CDD:276809	23/29 (79%)
		TPR repeat	602..630	CDD:276809	14/27 (52%)
		TPR repeat	673..701	CDD:276809	13/27 (48%)
		TPR repeat	706..736	CDD:276809	14/29 (48%)
		TPR repeat	741..770	CDD:276809	17/28 (61%)
		TPR repeat	776..799	CDD:276809	13/22 (59%)
		ParB_N_Srx	799..>841	CDD:452888	23/41 (56%)