Protein Alignment Tmtc3 and Tmtc2

DIOPT Version :10

• Sequence 1: NP_477246.2
• Gene: Tmtc3 / 37401
• FlyBaseID: FBgn0020312
• Length: 926
• Species: Drosophila melanogaster
• Sequence 2: NP_001164648.2
• Gene: Tmtc2 / 299762
• RGDID: 1309848
• Length: 836
• Species: Rattus norvegicus
• Alignment Length: 922
• Identity: 279/922 - (30%)
• Similarity: 406/922 - (44%)
• Gaps: 235/922 - (25%)

  Fly    45 IVCYYNSTQCGLVFDDISAIRDNKDLRPHTPLINVFLNDFWGTPMRKEQSHKSYRPLTVLTFRFN 109
            :..|.|:......:||..||:.|:||.|.||..::|.||||||.:....||||||||..|:||.|
  Rat    12 LALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLCTLSFRLN 76

  Fly   110 YLLHALEPFGYHLVNLLLHLSVCLLWRRVCRLLLRQCAASGSNAISAPSSSSVSQLNTCAFVASL 174
            :.:..|.|:.|||||:|||.:|..|:.|..:.||..                    ....|:|.|
  Rat    77 HAIGGLNPWSYHLVNVLLHAAVTGLFTRFSKALLGD--------------------GYWTFMAGL 121

  Fly   175 LFAVHPVHTEAVTGVVGRAELLSSICFLAAFLSYAKSVGDSGCPRRTNWLTLFGCFGSCLLASML 239
            :||.||:|||||.|:||||::.:|:.||.:.|.|.|.....|...|| |....|. |.|...|||
  Rat   122 MFASHPIHTEAVAGIVGRADVGASLFFLLSLLCYTKHCSTRGYSART-WGWFLGT-GLCAGCSML 184

  Fly   240 CKEQGITIAGICVVYELFVVHQLRPLHLCHFVLRLFDERTEQQSPKLANPSGIRRWSSSTLWKR- 303
            .||||:|:..:..||::||.|:|:                             .|....|::||
  Rat   185 WKEQGVTVLAVSAVYDVFVFHRLK-----------------------------MRQILPTIYKRK 220

  Fly   304 -LSFLVGITL------TLLVGRVYVMGSQLPIFTRFDNPASAADT-PERQLTYGYLIYLNCWLLL 360
             ||..:.|:|      :||..|:|.||::.|.|:..||||:.:|: ..|.||:.||...|.||||
  Rat   221 NLSLFLSISLLTFWGTSLLGARLYWMGNKPPSFSNSDNPAADSDSLLARTLTFFYLPTKNLWLLL 285

  Fly   361 CPSLLCCDWTMGTVPLLQGFTDSRNITT--------LLTFLAL----------GAMVA------- 400
            ||..|..||:|..||||:...|.||:.|        ||.:..|          |..|.
  Rat   286 CPDTLSFDWSMDAVPLLKTVCDWRNLHTVAFYSGLLLLAYCGLKSPSLEGECNGKAVTNGKQNAN 350

  Fly   401 ---------------------------KTCFTRNLALSRT---LIMCLGWMVLPFLPASNLFFPV 435
                                       |:|.::...|..|   :|:.|..:::||:||:||||.|
  Rat   351 GHSCYSDVEYRNSEIKPSFASKVENGIKSCVSQRPQLPSTENIVILSLSLLIIPFIPATNLFFYV 415

  Fly   436 GFVVAERILYMPSMGYCLLVAYGFEQLQRRGSLSWQRFSQA----ALAILLLTHALKTHQRNLDW 496
            |||:|||:||:||||:|||:..|...|..:..   :||.::    |.|.|::.:.|||..||.||
  Rat   416 GFVIAERVLYIPSMGFCLLITVGARALYVKVQ---KRFLKSLVFYATATLIVFYGLKTAIRNGDW 477

  Fly   497 RTEYSLFMSGVHVNQRNAKLYNNVGHALENEGKFEEALLYFQQAVRIQTDDIGAHINVGRTFNNL 561
            :.|..|:.||:.||.  ||.:.|:|:.|:::.|.
  Rat   478 QNEEMLYRSGIKVNP--AKAWGNLGNVLKSQSKI------------------------------- 509

  Fly   562 KRYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLANLIAKNQTRLEEADHLYRQAISM 626
               :|||.||  ..||:        |.:.:|    ::..||..|:.:| :|..||.|.|:.|:..
  Rat   510 ---SEAEIAY--RNALY--------YRSNMA----DMLYNLGLLLQEN-SRFAEALHYYKLAVGS 556

  Fly   627 RSDYVQAYINRGDILMKLNRTAQAQEVYEQALLYDNEN-----------ADIYYNLGVVFLEQGK 680
            |.....||:|.|.|||...:|.:|:..:.:.....:||           ....||||.::.|||:
  Rat   557 RPTLASAYLNTGIILMNQGKTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGR 621

  Fly   681 SQQAQVYFNKAIELYPEH--EQALLNSAILLQELGGEEARRVS-------------RSR------ 724
            .::|...:.:||:..|..  .|:|.|       :.||...|:|             ||:
  Rat   622 YEEALSVYREAIQKMPRQFAPQSLYN-------MMGEAYMRLSKLPEAEHWYMESLRSKTDHIPA 679

  Fly   725 --------------------LYKVLENDDQNEKVYFNLGMLAMDESSFDEAEQFFKRAIHLKADF 769
                                ..|.:|.|......|.:.|...::||...||.:..|:|..|.:..
  Rat   680 HLTYGKLLALTGRKSEAEKFFLKAIELDPTKGNCYMHYGQFLLEESRLTEAAEMAKKAAELDSTE 744

  Fly   770 RSALFNLALLLADTKRPLDAVPFLNQLIRHHPSHVKGLILLGDIYINHMKD-LDEAEKCYRSILH 833
            ...:||.|.:|........|..:.:...|..|::...|:.||.|.  |:.. |.:||..|...|.
  Rat   745 FDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAIL--HLNGRLQKAEANYLRALQ 807

  Fly   834 YDPHNTQGLHNL 845
            ..|.:.....||
  Rat   808 LKPDDVITQSNL 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	TMTC_DUF1736	323..396	CDD:462468	35/91 (38%)
		TPR	507..762	CDD:440225	69/306 (23%)
		TPR repeat	514..542	CDD:276809	6/27 (22%)
		TPR repeat	547..591	CDD:276809	8/43 (19%)
		TPR repeat	598..625	CDD:276809	10/26 (38%)
		TPR repeat	630..660	CDD:276809	9/29 (31%)
		LapB	634..896	CDD:442196	62/265 (23%)
		TPR repeat	665..693	CDD:276809	9/27 (33%)
		TPR repeat	737..764	CDD:276809	8/26 (31%)
		TPR repeat	803..834	CDD:276809	10/31 (32%)
		TPR repeat	839..867	CDD:276809	2/7 (29%)
Tmtc2	NP_001164648.2	ArnT	<78..>198	CDD:441412	53/141 (38%)
		TMTC_DUF1736	247..321	CDD:462468	32/73 (44%)
		TadD	439..558	CDD:444034	44/172 (26%)
		TPR repeat	493..521	CDD:276809	12/63 (19%)
		LapB	511..807	CDD:442196	79/319 (25%)
		TPR repeat	527..555	CDD:276809	11/32 (34%)
		TPR repeat	560..590	CDD:276809	9/29 (31%)
		TPR repeat	595..634	CDD:276809	9/38 (24%)
		TPR repeat	642..671	CDD:276809	7/35 (20%)
		TPR repeat	679..705	CDD:276809	1/25 (4%)
		TPR repeat	710..774	CDD:276809	14/63 (22%)
		TPR repeat	779..807	CDD:276809	9/29 (31%)