DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tmtc3 and Ifit2

DIOPT Version :9

Sequence 1:	NP_477246.2	Gene:	Tmtc3 / 37401	FlyBaseID:	FBgn0020312	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_001019924.1	Gene:	Ifit2 / 294091	RGDID:	1307804	Length:	464	Species:	Rattus norvegicus

Alignment Length:	407	Identity:	85/407 - (20%)
Similarity:	146/407 - (35%)	Gaps:	133/407 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   602 LANLIA-------KNQTRLE---EADHLYRQ----AISMRS-----DYVQAYINRGDILMK---L 644
            :.||:|       .|:..|:   ||:...||    .|.::|     :|...|.:.|.:...   |
  Rat    53 MCNLLAYVKHCRGLNEAALKCLGEAEDFIRQQHPDQIEIKSLVTWGNYAWVYYHMGQLSKAQEYL 117

  Fly   645 NRTAQAQEVYEQALLYDNENADIYYNLGVVFLEQGKSQQAQVYFNKAIELYPEHEQALLNSAILL 709
            ::..|..:.:......:|...|.......:...:.::::.:|.|.||:|..|::.::....||..
  Rat   118 DKVKQVCKKFSSPYRIENPVLDCEEGWARLKCTKNQNERMKVCFEKALEKDPKNPESTSGWAIAN 182

  Fly   710 QELGG-----------EEARRVSRSRLY-KV-----LENDDQNEKVYFNLGMLAMDESSF----- 752
            ..|..           |:|..:|....| ||     ||...:|.........|..|.|:.
  Rat   183 YRLDDWPASNDYIDSLEQAISLSPDNTYVKVLLAMKLEEVHENRAKELVEEALKKDPSAIDTMLG 247

  Fly   753 -----------DEAEQFFKRAI-----------HLKADFRSALFNLALLLADT-----KRPLDAV 790
                       |.|.|..|:|:           :|...:||.:.:: |...:|     :..|:|:
  Rat   248 AAKFYVKVHDTDRAIQLLKKALESMPNNAYVHYYLGCCYRSKVLHI-LNTEETTSNGNREKLEAL 311

  Fly   791 --PFLN---------QLIRHHPSHVKGLILLGDIYINHMKDLDEAEKCYRSILHYD--PHNTQGL 842
              |.||         ::|.:..||:.||      |:. .|..:||:..::...:.|  |...|.|
  Rat   312 IQPALNHLRKAEDIKEMIENSCSHLAGL------YVT-TKQYEEADYYFQKEFNKDLRPLPKQLL 369

  Fly   843 H----NLCVVFVERKRLAKAAACLQYAQRLAPAEDYIGRHLQIVLARLQKINKLPESAPE----- 898
            |    |.  .|.|||  .:..|...|.:.:                   |||:  ||.|:
  Rat   370 HLRYGNF--QFYERK--CEDRAIYHYMEGV-------------------KINR--ESKPKGKMRD 409

  Fly   899 -------RKLAYEDYDP 908
                   |:|:.::.||
  Rat   410 KLRKLALRRLSRDESDP 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	DUF1736	323..396	CDD:369859
		PEP_TPR_lipo	<513..871	CDD:274350	75/356 (21%)
		TPR repeat	514..542	CDD:276809
		TPR repeat	547..591	CDD:276809
		TPR repeat	598..625	CDD:276809	9/36 (25%)
		TPR repeat	630..660	CDD:276809	5/32 (16%)
		TPR repeat	665..693	CDD:276809	5/27 (19%)
		TPR repeat	737..764	CDD:276809	8/53 (15%)
		TPR repeat	803..834	CDD:276809	7/30 (23%)
		TPR repeat	839..867	CDD:276809	10/31 (32%)
Ifit2	NP_001019924.1	TPR_12	51..126	CDD:290160	16/72 (22%)
		TPR repeat	96..122	CDD:276809	4/25 (16%)
		TPR repeat	127..167	CDD:276809	6/39 (15%)
		TPR repeat	242..270	CDD:276809	5/27 (19%)
		TPR repeat	275..325	CDD:276809	10/50 (20%)
		TPR repeat	330..355	CDD:276809	8/31 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900