DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tmtc3 and Ifit1bl

DIOPT Version :9

Sequence 1:NP_477246.2 Gene:Tmtc3 / 37401 FlyBaseID:FBgn0020312 Length:926 Species:Drosophila melanogaster
Sequence 2:XP_220058.2 Gene:Ifit1bl / 294090 RGDID:1304872 Length:473 Species:Rattus norvegicus


Alignment Length:419 Identity:84/419 - (20%)
Similarity:163/419 - (38%) Gaps:90/419 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   539 QAVRIQTDDIGAHINVGRTFNNLKRYA--------EAEQAYVQAKALFPQAKPG----------- 584
            :|..::|:.:..:.|:|  .:||..|.        ||.|:..:|:||....:.|           
  Rat    45 EAKILETEFLDTNYNMG--MHNLMAYVRHLKGEQEEALQSLKEAEALIEGEQLGKRSLVTWGNCA 107

  Fly   585 -VSYHARIAPNHLNVFINLANLIAKNQTRLEEADHLYRQAIS---MRSDYVQAYINRGDILMKL- 644
             |.||              ...:|:.|..|::.:::.|:..|   .|.:..:.....|..|:|. 
  Rat   108 WVHYH--------------RGSLAEAQIYLDKVENVCREFASPFRYRMECAEIDCEEGWALLKCG 158

  Fly   645 -NRTAQAQEVYEQALLYDNENADIYYNLG---VVFLEQGKSQQAQVYFNKAIELYPE--HEQALL 703
             :...:|...:.:||..:.||.:  ||.|   ..|.....::.:.....||:.|.||  |.:.||
  Rat   159 GSNCTRAMACFAKALQEEPENPE--YNAGYAITAFRMDFSNEISLEPLRKAVRLNPEDPHLKVLL 221

  Fly   704 NSAILLQELG-GEEARRVSRSRLYKVLENDDQNEKVYFNLGMLAMDESSFDEAEQFFKRAIHLKA 767
              |:.||:|| .:||.:.....|.|:    .....::..:......:...:||.:|.:||:..|.
  Rat   222 --ALKLQDLGKQDEAEKHIEEALPKI----PSRNNIFGYVAKFYRRKGCVEEALEFLERALKTKP 280

  Fly   768 D-----------FRSALF------NLALLLADTKRP----LDAVPFLNQLIRHHPSHVKGLILLG 811
            .           .:|.:|      |:.....|.:|.    ..|:.:..:.:...|::.:..|.|.
  Rat   281 SSVYLHFQIGLCHKSRVFQIKEATNMHPKGKDRERADQSIRSAIYYFEKTLDLKPTYERAYIDLA 345

  Fly   812 DIYINHMKDLDEAEKCYRSIL----HYDPHNTQGLHNLCVVFVERKRLAKAAACLQYAQRLAPAE 872
            ::|. ..|..:|||:.::.:|    :.:.|..|.:|.....|.:....::..|...|.:      
  Rat   346 EMYA-ESKQFEEAEEAFQKVLSMLSNLEVHMQQEIHFRYGKFQQFHMKSENIAITHYLK------ 403

  Fly   873 DYIGRHLQIVLARLQKINKLPESAPERKL 901
               |..:::......|:.|..:...||::
  Rat   404 ---GLKIEVTSIFRDKLLKALQKLAERRM 429

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tmtc3NP_477246.2 DUF1736 323..396 CDD:369859
PEP_TPR_lipo <513..871 CDD:274350 79/387 (20%)
TPR repeat 514..542 CDD:276809 1/2 (50%)
TPR repeat 547..591 CDD:276809 15/63 (24%)
TPR repeat 598..625 CDD:276809 4/26 (15%)
TPR repeat 630..660 CDD:276809 6/31 (19%)
TPR repeat 665..693 CDD:276809 6/30 (20%)
TPR repeat 737..764 CDD:276809 5/26 (19%)
TPR repeat 803..834 CDD:276809 8/34 (24%)
TPR repeat 839..867 CDD:276809 5/27 (19%)
Ifit1blXP_220058.2 TPR_12 62..132 CDD:290160 16/83 (19%)
TNFRSF <124..>167 CDD:304602 7/42 (17%)
TPR repeat 144..174 CDD:276809 5/29 (17%)
TPR_11 214..280 CDD:290150 17/71 (24%)
TPR repeat 214..244 CDD:276809 11/31 (35%)
TPR repeat 282..333 CDD:276809 6/50 (12%)
TPR repeat 338..366 CDD:276809 7/28 (25%)
TPR repeat 371..406 CDD:276809 7/43 (16%)
TPR repeat 412..464 CDD:276809 4/18 (22%)
TPR_1 437..473 CDD:278916
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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