DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tmtc3 and Tmtc4

DIOPT Version :9

Sequence 1:NP_477246.2 Gene:Tmtc3 / 37401 FlyBaseID:FBgn0020312 Length:926 Species:Drosophila melanogaster
Sequence 2:XP_006252585.1 Gene:Tmtc4 / 290501 RGDID:1560183 Length:773 Species:Rattus norvegicus


Alignment Length:809 Identity:268/809 - (33%)
Similarity:406/809 - (50%) Gaps:124/809 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 LCICVACIVCYYNSTQCGLVFDDISAIRDNKDLRPHTPLINVFLNDFWGTPMRKEQSHKSYRPLT 102
            |.:....::|:..|.....||||..||.:||||:..|||.:::.:||||:.:....|||||||||
  Rat    55 LVVGFVSLLCFARSYDGDFVFDDSEAIVNNKDLQSDTPLADLWHHDFWGSRLSSNTSHKSYRPLT 119

  Fly   103 VLTFRFNYLLH-ALEPFGYHLVNLLLHLSVCLLWRRVCRLLL--RQCAASGSNAISAPSSSSVSQ 164
            |||||.||.|. ...|.|:|:||:|||..:.:|...|..:|.  .|.::.|.....||.:|    
  Rat   120 VLTFRVNYYLSGGFHPVGFHVVNILLHGGISILMLDVFSVLFGGLQYSSKGRRVHLAPRAS---- 180

  Fly   165 LNTCAFVASLLFAVHPVHTEAVTGVVGRAELLSSICFLAAFLSYAKSVGDSGCPRRTN----WLT 225
                 .:|:|||||||||||.|.||||||:||.::.||.:||.|.::..::|....|:    |:.
  Rat   181 -----LLAALLFAVHPVHTECVAGVVGRADLLCALFFLLSFLGYCRAFKETGNKEGTHSSTFWVL 240

  Fly   226 LFGCFGSCLLASMLCKEQGITIAGICVVYELFVVHQLRPLHLCHFVLRLFDERTEQQSPKLANPS 290
            |....|:   .:|||||||:|:.|:..|:::.|:.:|..|.....|||  .:::.:.:..|.|  
  Rat   241 LSIFLGA---VAMLCKEQGVTVLGLNAVFDILVIGRLDILVAVRKVLR--KDKSLESTGMLKN-- 298

  Fly   291 GIRRWSSSTLWKRLSFLVGITLTLLVGRVYVMGSQLPIFTRFDNPASAADTP-ERQLTYGYLIYL 354
                  ...|::.....:|.: |:|..|..:||:..|.||..|||||.||:. .|.:.|.|...|
  Rat   299 ------GGLLFRMALLTIGGS-TMLYIRWKIMGTGPPAFTEVDNPASFADSVLVRAINYNYYYSL 356

  Fly   355 NCWLLLCPSLLCCDWTMGTVPLLQGFTDSRNITTLLTFLALGAMVAKTCFTRNLALSRTLIMCLG 419
            |.||||||..||.||:||.:||::...|.|.|.....:|.|..::.:...:.:....|.|.:.||
  Rat   357 NAWLLLCPWWLCFDWSMGCIPLIKSVGDWRVIALAALWLCLIGLIFQALCSEDSCKRRILTLGLG 421

  Fly   420 WMVLPFLPASNLFFPVGFVVAERILYMPSMGYCLLVAYGFEQLQRRGSLSWQRFSQAALAI-LLL 483
            ::|:||||||||||.||||||||:||:||.|||:|:.:||..|.|.   :.::...||:.: :||
  Rat   422 FLVIPFLPASNLFFRVGFVVAERVLYLPSAGYCMLLTFGFGTLSRH---TKKKKPVAAIILGILL 483

  Fly   484 THALKTHQRNLDWRTEYSLFMSGVHVNQRNAKLYNNVGHALENEGKFEEALLYFQQAVRIQTDDI 548
            .:||:...|:.:||:|..||.|.:.|...|||::.|:|..|.::|....|:.|:::|||:.    
  Rat   484 INALRCVIRSGEWRSEDRLFRSALSVCPLNAKVHYNIGKNLADQGNQTAAIKYYREAVRLN---- 544

  Fly   549 GAHINVGRTFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLANLIAKNQTRL 613
                                                        |.:::...||.|:: |.:..|
  Rat   545 --------------------------------------------PKYVHAMNNLGNIL-KERNEL 564

  Fly   614 EEADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEVYEQALLYDNENADIYYNLGVVFLEQ 678
            :||:.|...|:.::.|:..|::|.|.:...|.|..:|::.|..|:.:..:..|.|||||.::.:.
  Rat   565 QEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEEAEQSYRTAIKHRRKYPDCYYNLGRLYADL 629

  Fly   679 GKSQQAQVYFNKAIELYPEHEQALLNSAILLQELGG-EEARRVSRSRLYKVLENDDQNEKVYFNL 742
            .:...|...:..|..:.|||..|..|..|||...|. .:|..|.|..| :::.||   ..:.|:|
  Rat   630 NRHVDALNAWRNATVMKPEHSLAWNNMVILLDNTGNLAQAEAVGREAL-QLIPND---HSLMFSL 690

  Fly   743 GMLAMDESSFDEAEQFFKRAIHLKADFRSALFNLALLLADTKRPLDAVPFLNQLIRHHPSHVKGL 807
            ..:......:.|:|..|.:||....:..|...|||:|.                  |...|    
  Rat   691 ANVLGKSQKYKESEALFLKAIKANPNVASYHGNLAVLY------------------HRWGH---- 733

  Fly   808 ILLGDIYINHMKDLDEAEKCYRSILHYDP 836
                         ||.|:|.|...|..||
  Rat   734 -------------LDSAKKHYEISLQLDP 749

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tmtc3NP_477246.2 DUF1736 323..396 CDD:369859 34/73 (47%)
PEP_TPR_lipo <513..871 CDD:274350 76/325 (23%)
TPR repeat 514..542 CDD:276809 9/27 (33%)
TPR repeat 547..591 CDD:276809 0/43 (0%)
TPR repeat 598..625 CDD:276809 9/26 (35%)
TPR repeat 630..660 CDD:276809 8/29 (28%)
TPR repeat 665..693 CDD:276809 8/27 (30%)
TPR repeat 737..764 CDD:276809 6/26 (23%)
TPR repeat 803..834 CDD:276809 7/30 (23%)
TPR repeat 839..867 CDD:276809
Tmtc4XP_006252585.1 DUF1736 324..398 CDD:285594 34/73 (47%)
TPR 513..771 CDD:223533 76/325 (23%)
TPR_1 514..547 CDD:278916 12/80 (15%)
TPR repeat 514..542 CDD:276809 9/27 (33%)
TPR_17 536..569 CDD:290167 12/81 (15%)
TPR repeat 547..577 CDD:276809 9/30 (30%)
TPR_1 582..615 CDD:278916 8/32 (25%)
TPR repeat 582..610 CDD:276809 8/27 (30%)
TPR repeat 616..642 CDD:276809 7/25 (28%)
TPR repeat 650..678 CDD:276809 10/28 (36%)
TPR repeat 683..713 CDD:276809 8/32 (25%)
TPR_17 706..739 CDD:290167 13/67 (19%)
TPR repeat 718..746 CDD:276809 12/62 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1320023at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

Return to query results.
Submit another query.