DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tmtc3 and Kdm6b

DIOPT Version :9

Sequence 1:	NP_477246.2	Gene:	Tmtc3 / 37401	FlyBaseID:	FBgn0020312	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	XP_030101676.1	Gene:	Kdm6b / 216850	MGIID:	2448492	Length:	1642	Species:	Mus musculus

Alignment Length:	262	Identity:	51/262 - (19%)
Similarity:	88/262 - (33%)	Gaps:	93/262 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   420 WMVLPFLPASNLFFPVGFVVAERILYMPSMGYCLLVAYGFEQLQRRGSLSWQRFSQAALAILLLT 484
            |.:|..|.|||:  ||                     |.|  :||.|.|.|             .
Mouse  1437 WPILDDLYASNI--PV---------------------YRF--VQRPGDLVW-------------I 1463

  Fly   485 HALKTHQ-------RNLDWRT------EYSLFMSGVHVNQ-RNAKLYNNVGHALENEGKFEEALL 535
            :|...|.       .|:.|..      :|.|.:.....|: :|.|....:.|...|..:
Mouse  1464 NAGTVHWVQATGWCNNIAWNVGPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVAR------ 1522

  Fly   536 YFQQAVRIQTDDIGAHINVGRTFNNLK--RYAEAEQAYVQAKALFPQAKPGVSYHARIAP----- 593
                .|:|...|:         |..:|  .....:...||.::|....|. ::|..|:..
Mouse  1523 ----TVKISDPDL---------FKMIKFCLLQSMKHCQVQRESLVRAGKK-IAYQGRVKDEPAYY 1573

  Fly   594 -NHLNVFI-NLANLIAKNQTR---LEEADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEV 653
             |..:|.: |:..:.::|.:|   |...:...|:    ||..:|     |.::::..||.:..:.
Mouse  1574 CNECDVEVFNILFVTSENGSRNTYLVHCEGCARR----RSAGLQ-----GVVVLEQYRTEELAQA 1629

  Fly   654 YE 655
            |:
Mouse  1630 YD 1631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	DUF1736	323..396	CDD:369859
		PEP_TPR_lipo	<513..871	CDD:274350	29/155 (19%)
		TPR repeat	514..542	CDD:276809	3/27 (11%)
		TPR repeat	547..591	CDD:276809	8/45 (18%)
		TPR repeat	598..625	CDD:276809	6/30 (20%)
		TPR repeat	630..660	CDD:276809	5/26 (19%)
		TPR repeat	665..693	CDD:276809
		TPR repeat	737..764	CDD:276809
		TPR repeat	803..834	CDD:276809
		TPR repeat	839..867	CDD:276809
Kdm6b	XP_030101676.1	TPR repeat	106..136	CDD:276809
		JmjC	1342..1406	CDD:214721
		JmjC	1376..1484	CDD:396791	19/84 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900