DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tmtc3 and Ttc24

DIOPT Version :9

Sequence 1:	NP_477246.2	Gene:	Tmtc3 / 37401	FlyBaseID:	FBgn0020312	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_766114.1	Gene:	Ttc24 / 214191	MGIID:	2443841	Length:	334	Species:	Mus musculus

Alignment Length:	151	Identity:	39/151 - (25%)
Similarity:	61/151 - (40%)	Gaps:	17/151 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   650 AQEVYEQAL---LYDNENADIYYNLGVVFLEQGKSQQAQVYFNKAIELYP------EHEQALLNS 705
            |.|.:.|||   ...:|.|.:..|||:.....|...:||.:..||..|:.      |..::....
Mouse    54 AVEAFLQALPLCRQPSEQATVLQNLGMTHNVLGNYWEAQEFHQKAASLHGSVGQRWEQGRSFSGL 118

  Fly   706 AILLQELGGEEARRVSRSRLYKVLENDDQNE-----KVYFNLGMLAMDESSFDEAEQFFKRAIHL 765
            |..|.:||  :.|....|.|:.:....|..:     :....||..|......|:|.:::|.|:.|
Mouse   119 AFSLSQLG--DHRAAWDSYLHALQAAQDTGDVKGQWQACEGLGAAAARLGQHDQALKYYKEALAL 181

  Fly   766 -KADFRSALFNLALLLADTKR 785
             :.:..|....|...|||..|
Mouse   182 CQHEPSSVRERLVAKLADAMR 202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	DUF1736	323..396	CDD:369859
		PEP_TPR_lipo	<513..871	CDD:274350	39/151 (26%)
		TPR repeat	514..542	CDD:276809
		TPR repeat	547..591	CDD:276809
		TPR repeat	598..625	CDD:276809
		TPR repeat	630..660	CDD:276809	5/12 (42%)
		TPR repeat	665..693	CDD:276809	9/27 (33%)
		TPR repeat	737..764	CDD:276809	7/26 (27%)
		TPR repeat	803..834	CDD:276809
		TPR repeat	839..867	CDD:276809
Ttc24	NP_766114.1	TPR 1	35..68		5/13 (38%)
		TPR repeat	38..66	CDD:276809	5/11 (45%)
		TPR_12	68..144	CDD:290160	19/77 (25%)
		TPR 2	72..105		10/32 (31%)
		TPR repeat	72..100	CDD:276809	9/27 (33%)
		TPR repeat	111..141	CDD:276809	7/31 (23%)
		TPR 3	112..145		7/34 (21%)
		TPR_12	113..183	CDD:290160	16/71 (23%)
		TPR 4	152..185		8/32 (25%)
		TPR_1	152..184	CDD:278916	8/31 (26%)
		TPR repeat	152..180	CDD:276809	7/27 (26%)
		TPR_12	158..214	CDD:290160	14/45 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..258
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900