Protein Alignment Tmtc3 and F38B6.6

DIOPT Version :10

• Sequence 1: NP_477246.2
• Gene: Tmtc3 / 37401
• FlyBaseID: FBgn0020312
• Length: 926
• Species: Drosophila melanogaster
• Sequence 2: NP_509123.2
• Gene: F38B6.6 / 185454
• WormBaseID: WBGene00018175
• Length: 690
• Species: Caenorhabditis elegans
• Alignment Length: 845
• Identity: 234/845 - (27%)
• Similarity: 376/845 - (44%)
• Gaps: 184/845 - (21%)

  Fly    10 HQYAPSTLPRERE-REGATNSPQRNLLEFLCICVACIVCYYNSTQCGLVFDDISAIRDNKDLRPH 73
            |:.:.|..|.:|. :|...:...||||..:.:   .|:.|.:......||||..:|.:|..:...
 Worm     7 HKVSGSCDPGDRSPKEKGRSQGIRNLLILISL---SIIPYLSCLGGDFVFDDAESIVNNPIVNGK 68

  Fly    74 TPLINVFLNDFWGTPMRKEQSHKSYRPLTVLTFRFNYLLHALEPFGYHLVNLLLHLSVCLLWRRV 138
            .||:.:|..||||..:....|||||||:|..||..||.||.....|||:||::.|....|::.::
 Worm    69 DPLLQIFSRDFWGRSISSSNSHKSYRPVTTFTFWLNYKLHETSTLGYHVVNIICHTVATLVFYKL 133

  Fly   139 CRLLLRQCAASGSNAISAPSSSSVSQLNTCAFVASLLFAVHPVHTEAVTGVVGRAELLSSICFLA 203
            .:.|                 ..:......||.||:||||||||||||..:.||||||.:|..||
 Worm   134 GKQL-----------------EHIFDFFNIAFSASILFAVHPVHTEAVANITGRAELLMTIFSLA 181

  Fly   204 AFLSYAKSVGDSGCPRRTNWLTLFGC-FGSCLLASMLCKEQGITIAGICVVYELFVVHQLRPLHL 267
            |.:.:.|:       |..|      | |...::.|.|.||||:....|.:..: |:.|:     .
 Worm   182 ALILHVKN-------REIN------CKFVLLVILSTLSKEQGLMTIPIAICID-FLAHR-----S 227

  Fly   268 CHFVLRLFDERTEQQSPKLANPSGIRRWSSSTLWKRLSFLVGITLTLLVG--RVYVMGSQLPIFT 330
            |                                  |.:|:..|.|.:.:|  |:.|.|.:...||
 Worm   228 C----------------------------------RSNFVRMICLLVAIGFLRMMVNGFEAAKFT 258

  Fly   331 RFDNPASAADTP-ERQLTYGYLIYLNCWLLLCPSLLCCDWTMGTVPLLQGFTDSRNITTLL--TF 392
            :.|||.:..::. .|.:.|.|:...:.:||:.|..||.|::||.:..:....|.|.::.:|  |.
 Worm   259 KLDNPTAFLNSKFYRMINYTYIWLYHAYLLVIPVNLCFDYSMGCISSITTMWDLRALSPVLIFTI 323

  Fly   393 LALGAMVAKTCFTRNLALSRTLIMCLGWMVLPFLPASNLFFPVGFVVAERILYMPSMGYCLLVAY 457
            :.:|......|      .:.||...:|  ::.||||||:||.|||.:|||:||:||.|:|||.|.
 Worm   324 VIIGVKFQNEC------RAFTLSSLMG--IISFLPASNIFFTVGFSIAERVLYLPSAGFCLLCAI 380

  Fly   458 GFEQLQRRGSLSWQRFSQAALAILLLTHALKTHQRNLDWRTEYSLFMSGVHVNQRNAKLYNNVGH 522
            .|::|    |:.::.....::.::||..: ||::|:.:|:||.||:.||:.|...|||::.|:|.
 Worm   381 IFKKL----SVHFKNADVLSITLILLLIS-KTYRRSGEWKTELSLYSSGLSVCPTNAKIHYNLGK 440

  Fly   523 ALENEGKFEEALLYFQQAVRIQTDDIGAHINVGRTFNNLKRYAEAEQAYVQAKALFPQAKPGVSY 587
            .|.:.|..::|...:..|:::                        :.:|.||
 Worm   441 VLGDNGLTKDAEKNYWNAIKL------------------------DPSYEQA------------- 468

  Fly   588 HARIAPNHLNVFINLANLIAKNQTRLEEADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQE 652
                    ||   ||.||:.|:... :.|:.|..:|:::|..:..|::|.|...|.|.:..:|::
 Worm   469 --------LN---NLGNLLEKSGDS-KTAESLLARAVTLRPSFAVAWMNLGISQMNLKKYYEAEK 521

  Fly   653 VYEQALLYDNENADIYYNLGVVFLEQGKSQQAQVYFNKAIELYPEHEQALLNSAILLQELGGEEA 717
            ..:.:||....:|...:||||::....:.:.|...:..|..:.|.|.|:..|..::|..| .:.:
 Worm   522 SLKNSLLIRPNSAHCLFNLGVLYQRTNRDEMAMSAWKNATRIDPSHSQSWTNLFVVLDHL-SQCS 585

  Fly   718 RRVSRSRLYKVLENDDQNEKVYFNLGMLAMDESSFDEAEQFFKRAIHLKADFRSALF--NLALLL 780
            :.:..|  |:.|.:.....:|:..:|......|:|..||...|.||.|..  .|.||  ||.:|
 Worm   586 QVIDLS--YQALSSVPNESRVHMQIGSCHAKHSNFTAAENHIKSAIDLNP--TSVLFHANLGIL- 645

  Fly   781 ADTKRPLDAVPFLNQLIRHHPSHVKGLILLGDIYINHMKDLDEAEKCYRSILHYDPHNTQGLHNL 845
                        ..::.||                      .|||..||.:|..|..|.....||
 Worm   646 ------------YQRMSRH----------------------KEAESQYRIVLALDSKNIVAKQNL 676

  Fly   846  845
             Worm   677  676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	TMTC_DUF1736	323..396	CDD:462468	21/75 (28%)
		TPR	507..762	CDD:440225	55/254 (22%)
		TPR repeat	514..542	CDD:276809	8/27 (30%)
		TPR repeat	547..591	CDD:276809	3/43 (7%)
		TPR repeat	598..625	CDD:276809	8/26 (31%)
		TPR repeat	630..660	CDD:276809	7/29 (24%)
		LapB	634..896	CDD:442196	51/214 (24%)
		TPR repeat	665..693	CDD:276809	7/27 (26%)
		TPR repeat	737..764	CDD:276809	8/26 (31%)
		TPR repeat	803..834	CDD:276809	6/30 (20%)
		TPR repeat	839..867	CDD:276809	2/7 (29%)
F38B6.6	NP_509123.2	TMTC_DUF1736	251..325	CDD:462468	21/73 (29%)
		TPR	425..>595	CDD:440225	47/221 (21%)
		TPR repeat	432..460	CDD:276809	8/27 (30%)
		TPR repeat	467..494	CDD:276809	12/51 (24%)
		TPR repeat	499..529	CDD:276809	7/29 (24%)
		NrfG	518..679	CDD:443378	47/199 (24%)
		TPR repeat	534..560	CDD:276809	6/25 (24%)
		TPR repeat	568..596	CDD:276809	6/30 (20%)
		TPR repeat	601..631	CDD:276809	9/29 (31%)
		TPR repeat	636..664	CDD:276809	12/62 (19%)