DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tmtc3 and TTC24

DIOPT Version :9

Sequence 1:NP_477246.2 Gene:Tmtc3 / 37401 FlyBaseID:FBgn0020312 Length:926 Species:Drosophila melanogaster
Sequence 2:NP_001099139.2 Gene:TTC24 / 164118 HGNCID:32348 Length:582 Species:Homo sapiens


Alignment Length:298 Identity:71/298 - (23%)
Similarity:115/298 - (38%) Gaps:47/298 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   519 NVGHALENEGKFEEALLYFQQAV---RIQTDDIGAHINVGRTFNNLKR-------YAEAEQAYVQ 573
            ||..|....|:..:||.::.:|:   :.|.|...|...:|..:..|.:       ..||.|||.|
Human   122 NVALAYHALGELPQALAWYHRALGHYQPQGDQGEAWAKMGACYQALGQPELAAHCLQEASQAYAQ 186

  Fly   574 -----AKALFPQAKPGVSYHA-RIAPNHLNVFINLANLIAKNQTRLEEADHLYRQAISMRSDYVQ 632
                 |.||...|..|....: |.....:...:..:..:|:..|......|||       :|...
Human   187 ERQLRAAALALGAAAGCMLKSGRHRVGEVVQVLEKSRRLAERSTERRLLGHLY-------NDLGL 244

  Fly   633 AYINRGDILMKLNRTAQAQEVYEQAL---LYDNENADIYYNLGVVFLEQGKSQQAQVYFNKAIEL 694
            .|       .:|.....|.|.:.|||   ....|.|.:..|||:.....|..|:|:.:..||.:|
Human   245 GY-------SQLQLFPLAVEAFLQALPLCWVPGEQATVLRNLGMAHNALGNYQEAREFHQKAADL 302

  Fly   695 YP------EHEQALLNSAILLQELGGEEARRVSRSRLYKVLENDDQNE-----KVYFNLGMLAMD 748
            :.      |..::..:.|..|.:||..:|.|  .:.|:.:....|..:     :....||..|..
Human   303 HGSVGQRWEQGRSFGSLAFALSQLGDHKAAR--DNYLHALQAARDSGDMKGQWQACEGLGAAAAR 365

  Fly   749 ESSFDEAEQFFKRAI-HLKADFRSALFNLALLLADTKR 785
            ...:|:|.:::|.|: ..:.:..|....|...||||.|
Human   366 LGQYDQALKYYKEALAQCQKEPDSVRERLVAKLADTVR 403

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tmtc3NP_477246.2 DUF1736 323..396 CDD:369859
PEP_TPR_lipo <513..871 CDD:274350 71/298 (24%)
TPR repeat 514..542 CDD:276809 7/25 (28%)
TPR repeat 547..591 CDD:276809 14/56 (25%)
TPR repeat 598..625 CDD:276809 5/26 (19%)
TPR repeat 630..660 CDD:276809 7/32 (22%)
TPR repeat 665..693 CDD:276809 9/27 (33%)
TPR repeat 737..764 CDD:276809 7/27 (26%)
TPR repeat 803..834 CDD:276809
TPR repeat 839..867 CDD:276809
TTC24NP_001099139.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..31
TPR_12 36..105 CDD:290160
TPR 1 36..69
TPR repeat 36..64 CDD:276809
TPR 2 79..112
TPR_12 80..148 CDD:290160 7/25 (28%)
TPR repeat 81..111 CDD:276809
TPR repeat 116..146 CDD:276809 7/23 (30%)
TPR 3 117..150 7/27 (26%)
TPR_11 121..180 CDD:290150 12/57 (21%)
TPR 4 154..187 8/32 (25%)
TPR repeat 154..180 CDD:276809 3/25 (12%)
TPR_12 232..302 CDD:290160 21/83 (25%)
TPR 5 236..271 11/48 (23%)
TPR repeat 238..264 CDD:276809 9/39 (23%)
TPR_12 271..345 CDD:290160 19/75 (25%)
TPR 6 273..306 10/32 (31%)
TPR 273..302 CDD:197478 9/28 (32%)
TPR repeat 273..301 CDD:276809 9/27 (33%)
TPR repeat 312..342 CDD:276809 7/31 (23%)
TPR 7 313..346 7/34 (21%)
TPR_12 314..385 CDD:290160 15/72 (21%)
TPR 8 353..386 7/32 (22%)
TPR repeat 353..381 CDD:276809 7/27 (26%)
TPR_1 353..>380 CDD:278916 6/26 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 418..481
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 548..582
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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