DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tmtc3 and DNAAF4

DIOPT Version :9

Sequence 1:	NP_477246.2	Gene:	Tmtc3 / 37401	FlyBaseID:	FBgn0020312	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_570722.2	Gene:	DNAAF4 / 161582	HGNCID:	21493	Length:	420	Species:	Homo sapiens

Alignment Length:	319	Identity:	67/319 - (21%)
Similarity:	117/319 - (36%)	Gaps:	83/319 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   451 YCLLVAYGFEQLQRRGSLSWQRFSQAALAILLLTHALKTHQRNLD----WRTEYSLFMSGVHVNQ 511
            |.|.|....|:.:|: .:...:.::...|...| .|.|.:||..:    .:.|..|......:.:
Human   128 YALSVMMKIEEEERK-KIEDMKENERIKATKAL-EAWKEYQRKAEEQKKIQREEKLCQKEKQIKE 190

  Fly   512 RNAKL------YNNVGHALENEGKFEEALLYFQQAVRIQTDDIGAHINVG--------RTFNNLK 562
            ...|:      .|.....|..:|:..|.:.    ..:::.|.|.|..:||        |.|....
Human   191 ERKKIKYKSLTRNLASRNLAPKGRNSENIF----TEKLKEDSIPAPRSVGSIKINFTPRVFPTAL 251

  Fly   563 RYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLANLI-----AKNQTRLEE------- 615
            |.::..:   :.:.|..||:      ||.|.|     .::|.|.     .||...|::
Human   252 RESQVAE---EEEWLHKQAE------ARRAMN-----TDIAELCDLKEEEKNPEWLKDKGNKLFA 302

  Fly   616 ------ADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEVYEQAL------LYDNENADI- 667
                  |.:.|..||.:.:.....|:||....:||....:|.|...:||      :.||.||.:
Human   303 TENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKALELLMPPVTDNANARMK 367

  Fly   668 -YYNLGVVFLEQGKSQQAQVYFNKAIELYPE----HEQAL-LNSAILLQELGGEEARRV 720
             :...|..|.:              :|||.|    :|.|| ::.:..:.::..|:.|.|
Human   368 AHVRRGTAFCQ--------------LELYVEGLQDYEAALKIDPSNKIVQIDAEKIRNV 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	DUF1736	323..396	CDD:369859
		PEP_TPR_lipo	<513..871	CDD:274350	54/253 (21%)
		TPR repeat	514..542	CDD:276809	5/33 (15%)
		TPR repeat	547..591	CDD:276809	11/51 (22%)
		TPR repeat	598..625	CDD:276809	8/44 (18%)
		TPR repeat	630..660	CDD:276809	9/35 (26%)
		TPR repeat	665..693	CDD:276809	3/29 (10%)
		TPR repeat	737..764	CDD:276809
		TPR repeat	803..834	CDD:276809
		TPR repeat	839..867	CDD:276809
DNAAF4	NP_570722.2	Mediates interaction with ESR1 and STUB1. /evidence=ECO:0000269\|PubMed:19423554	7..103
		p23_DYX1C1_like	10..87	CDD:107226
		TPR_11	289..353	CDD:290150	15/63 (24%)
		TPR 1	290..323		5/32 (16%)
		TPR repeat	290..318	CDD:276809	4/27 (15%)
		TPR repeat	323..353	CDD:276809	9/29 (31%)
		TPR 2	324..357		9/32 (28%)
		TPR repeat	364..394	CDD:276809	9/43 (21%)
		TPR 3	366..399		9/46 (20%)
		TPR_1	367..399	CDD:278916	9/45 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900