DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tmtc3 and TMTC3

DIOPT Version :9

Sequence 1:	NP_477246.2	Gene:	Tmtc3 / 37401	FlyBaseID:	FBgn0020312	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_861448.2	Gene:	TMTC3 / 160418	HGNCID:	26899	Length:	914	Species:	Homo sapiens

Alignment Length:	884	Identity:	457/884 - (51%)
Similarity:	585/884 - (66%)	Gaps:	68/884 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 NLLEFLCICVACIVCYYNSTQCGLVFDDISAIRDNKDLRPHTPLINVFLNDFWGTPMRKEQSHKS 97
            ||.|...|......||:||..||.||||:|||.|||||.|.|||..:|.||||||||.:|:||||
Human     5 NLKEITLIVGVVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEERSHKS 69

  Fly    98 YRPLTVLTFRFNYLLHALEPFGYHLVNLLLHLSVCLLWRRVCRLLLRQCAASGSNAISAPSSSSV 162
            ||||||||||.||||..|:|..|||:|::.|..|.:::.:||:|.|             .:.|||
Human    70 YRPLTVLTFRLNYLLSELKPMSYHLLNMIFHAVVSVIFLKVCKLFL-------------DNKSSV 121

  Fly   163 SQLNTCAFVASLLFAVHPVHTEAVTGVVGRAELLSSICFLAAFLSYAKSVGDSGCPRRTNW---- 223
                    :|||||||||:||||||||||||||||||.||||||||.:|.|..   ....|
Human   122 --------IASLLFAVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYTRSKGPD---NSIIWTPIA 175

  Fly   224 LTLFGCFGSCLLASMLCKEQGITIAGICVVYELFVVHQLRPLHLCHFVLRLFDERTEQQSPKLAN 288
            ||:|     .:..:.||||||||:.|||.|||:|:..        .:.|           |.|..
Human   176 LTVF-----LVAVATLCKEQGITVVGICCVYEVFIAQ--------GYTL-----------PLLCT 216

  Fly   289 PSG-IRRWSSSTLWKRLSFLVGI------TLTLLVGRVYVMGSQLPIFTRFDNPASAADTPERQL 346
            .:| ..|...|..:..|..||.:      ||.|:|.||.|:.||||:||||||||:.:.||.|||
Human   217 TAGQFLRGKGSIPFSMLQTLVKLIVLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPTPTRQL 281

  Fly   347 TYGYLIYLNCWLLLCPSLLCCDWTMGTVPLLQGFTDSRNITTLLTFLALGAMVAKTCFTRNLALS 411
            |:.||:.:|.||||.||.|||||||||:||::...|.||:.|...|..|| |:.......:...|
Human   282 TFNYLLPVNAWLLLNPSELCCDWTMGTIPLIESLLDIRNLATFTFFCFLG-MLGVFSIRYSGDSS 345

  Fly   412 RTLIMCLGWMVLPFLPASNLFFPVGFVVAERILYMPSMGYCLLVAYGFEQLQRRG---SLSWQRF 473
            :|::|.|..|.|||:||||||||||||||||:||:||||:|:|||:|::::..:.   .|||
Human   346 KTVLMALCLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISTKSVFKKLSW--- 407

  Fly   474 SQAALAILLLTHALKTHQRNLDWRTEYSLFMSGVHVNQRNAKLYNNVGHALENEGKFEEALLYFQ 538
              ..|::::|||:|||..||.||.:||:||||.:.||:.||||:||||||||||..||.||.||.
Human   408 --ICLSMVILTHSLKTFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFL 470

  Fly   539 QAVRIQTDDIGAHINVGRTFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLA 603
            ||..:|.||||||:|||||:.||.|..|||::|:.||:|.||..||..|.||||||||||:||||
Human   471 QATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLA 535

  Fly   604 NLIAKNQTRLEEADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEVYEQALLYDNENADIY 668
            |||..|::||||||.|||||||||.|:.||||:||::|:|:|:..:|:|.|.:||..|..|||::
Human   536 NLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLW 600

  Fly   669 YNLGVVFLEQGKSQQAQVYFNKAIELYPEHEQALLNSAILLQELGGEEARRVSRSRLYKVLENDD 733
            |||.:|.:|..:..:|...||:|:||.|:|:.||.||||::||.|..:.|..:|.||...:..:.
Human   601 YNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEP 665

  Fly   734 QNEKVYFNLGMLAMDESSFDEAEQFFKRAIHLKADFRSALFNLALLLADTKRPLDAVPFLNQLIR 798
            .:...||||||||||:...:|||.:.|:||.|:|||||||||||||.:.|.:.|.|:|.|.:|:|
Human   666 LDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLR 730

  Fly   799 HHPSHVKGLILLGDIYINHMKDLDEAEKCYRSILHYDPHNTQGLHNLCVVFVERKRLAKAAACLQ 863
            ::|.|:|||||.|||.:|..||:..|:||:..||..||.|.||.||||||:.|.|.|.||..||.
Human   731 YYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLL 795

  Fly   864 YAQRLAPAEDYIGRHLQIVLARLQKINKLPESAPERKLA 902
            ....|||.|:||.|||.||..::...:.:....|..|::
Human   796 ETLALAPHEEYIQRHLNIVRDKISSSSFIEPIFPTSKIS 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	DUF1736	323..396	CDD:369859	43/72 (60%)
		PEP_TPR_lipo	<513..871	CDD:274350	202/357 (57%)
		TPR repeat	514..542	CDD:276809	21/27 (78%)
		TPR repeat	547..591	CDD:276809	26/43 (60%)
		TPR repeat	598..625	CDD:276809	20/26 (77%)
		TPR repeat	630..660	CDD:276809	14/29 (48%)
		TPR repeat	665..693	CDD:276809	11/27 (41%)
		TPR repeat	737..764	CDD:276809	15/26 (58%)
		TPR repeat	803..834	CDD:276809	17/30 (57%)
		TPR repeat	839..867	CDD:276809	15/27 (56%)
TMTC3	NP_861448.2	DUF1736	259..331	CDD:312047	43/71 (61%)
		TPR 1	412..445		18/32 (56%)
		TPR_11	<435..802	CDD:330823	206/366 (56%)
		TPR 2	446..479		22/32 (69%)
		TPR repeat	446..474	CDD:276809	21/27 (78%)
		TPR repeat	479..523	CDD:276809	26/43 (60%)
		TPR 3	481..513		19/31 (61%)
		TPR 4	528..562		26/33 (79%)
		TPR repeat	530..557	CDD:276809	20/26 (77%)
		TPR repeat	562..592	CDD:276809	14/29 (48%)
		TPR 5	563..596		15/32 (47%)
		TPR repeat	597..625	CDD:276809	11/27 (41%)
		TPR 7	668..701		18/32 (56%)
		TPR repeat	668..696	CDD:276809	15/27 (56%)
		TPR repeat	701..731	CDD:276809	17/29 (59%)
		TPR 8	703..735		17/31 (55%)
		TPR 9	736..770		18/33 (55%)
		TPR repeat	736..765	CDD:276809	15/28 (54%)
		TPR repeat	771..799	CDD:276809	15/27 (56%)
		TPR 10	772..804		18/31 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	847..891
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158858
Domainoid	1	1.000	229	1.000	Domainoid score	I2487
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H27616
Inparanoid	1	1.050	844	1.000	Inparanoid score	I445
Isobase	1	0.950	-	0	Normalized mean entropy	S3607
OMA	1	1.010	-	-		QHG45272
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	1	1.000	-	-		FOG0007335
OrthoInspector	1	1.000	-	-		oto89206
orthoMCL	1	0.900	-	-		OOG6_106603
Panther	1	1.100	-	-	LDO	PTHR44395
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4792
SonicParanoid	1	1.000	-	-		X4132
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750