DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tmtc3 and TMTC2

DIOPT Version :9

Sequence 1:	NP_477246.2	Gene:	Tmtc3 / 37401	FlyBaseID:	FBgn0020312	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_689801.1	Gene:	TMTC2 / 160335	HGNCID:	25440	Length:	836	Species:	Homo sapiens

Alignment Length:	915	Identity:	279/915 - (30%)
Similarity:	409/915 - (44%)	Gaps:	221/915 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 IVCYYNSTQCGLVFDDISAIRDNKDLRPHTPLINVFLNDFWGTPMRKEQSHKSYRPLTVLTFRFN 109
            :..|.|:......:||..||:.|:||.|.||..::|.||||||.:....||||||||..|:||.|
Human    12 LALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLCTLSFRLN 76

  Fly   110 YLLHALEPFGYHLVNLLLHLSVCLLWRRVCRLLLRQCAASGSNAISAPSSSSVSQLNTCAFVASL 174
            :.:..|.|:.|||||:|||.:|..|:....::||..                    ....|:|.|
Human    77 HAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGD--------------------GYWTFMAGL 121

  Fly   175 LFAVHPVHTEAVTGVVGRAELLSSICFLAAFLSYAKSVGDSGCPRRTNWLTLFGCFGSCLLASML 239
            :||.||:|||||.|:||||::.:|:.||.:.|.|.|.....|...|| |....|. |.|...|||
Human   122 MFASHPIHTEAVAGIVGRADVGASLFFLLSLLCYIKHCSTRGYSART-WGWFLGS-GLCAGCSML 184

  Fly   240 CKEQGITIAGICVVYELFVVHQLRPLHLCHFVLRLFDERTEQQSPKLANPSGIRRWSSSTLWKR- 303
            .||||:|:..:..||::||.|:|               :.:|..|              |::||
Human   185 WKEQGVTVLAVSAVYDVFVFHRL---------------KIKQILP--------------TIYKRK 220

  Fly   304 -LSFLVGITL------TLLVGRVYVMGSQLPIFTRFDNPASAADT-PERQLTYGYLIYLNCWLLL 360
             ||..:.|:|      :||..|:|.||::.|.|:..||||:.:|: ..|.||:.||...|.||||
Human   221 NLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLL 285

  Fly   361 CPSLLCCDWTMGTVPLLQGFTDSRNITT--------LLTFLAL----------GAMV-------- 399
            ||..|..||:|..||||:...|.||:.|        ||.:..|          |..|
Human   286 CPDTLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNAN 350

  Fly   400 --------------AKTCFT-------RNLALSRT--------LIMCLGWMVLPFLPASNLFFPV 435
                          .|:.|.       :|....||        :::.|..:::||:||:||||.|
Human   351 GHSCLSDVEYQNSETKSSFASKVENGIKNDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYV 415

  Fly   436 GFVVAERILYMPSMGYCLLVAYGFEQLQRRGSLSWQRFSQA----ALAILLLTHALKTHQRNLDW 496
            |||:|||:||:||||:|||:..|...|..:..   :||.::    |.|.|::.:.|||..||.||
Human   416 GFVIAERVLYIPSMGFCLLITVGARALYVKVQ---KRFLKSLIFYATATLIVFYGLKTAIRNGDW 477

  Fly   497 RTEYSLFMSGVHVNQRNAKLYNNVGHALENEGKFEEALLYFQQAVRIQTDDIGAHINVGRTFNNL 561
            :.|..|:.||:.||.  ||.:.|:|:.|:::.|.
Human   478 QNEEMLYRSGIKVNP--AKAWGNLGNVLKSQSKI------------------------------- 509

  Fly   562 KRYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLANLIAKNQTRLEEADHLYRQAISM 626
               :|||.||  ..||:        |.:.:|    ::..||..|:.:| :|..||.|.|:.||..
Human   510 ---SEAESAY--RNALY--------YRSNMA----DMLYNLGLLLQEN-SRFAEALHYYKLAIGS 556

  Fly   627 RSDYVQAYINRGDILMKLNRTAQAQEVYEQALLYDNEN-----------ADIYYNLGVVFLEQGK 680
            |.....||:|.|.|||...||.:|:..:.:.....:||           ....||||.::.|||.
Human   557 RPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGH 621

  Fly   681 SQQAQVYFNKAIELYPEH--EQALLN----SAILLQELGGEE----------------------- 716
            .::|...:.:||:..|..  .|:|.|    :.:.|.:|...|
Human   622 YEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKL 686

  Fly   717 ----ARRVSRSRLY-KVLENDDQNEKVYFNLGMLAMDESSFDEAEQFFKRAIHLKADFRSALFNL 776
                .|:....:|: |.:|.|......|.:.|...::|:...||.:..|:|..|.:.....:||.
Human   687 LALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNA 751

  Fly   777 ALLLADTKRPLDAVPFLNQLIRHHPSHVKGLILLGDIYINHMKD-LDEAEKCYRSILHYDPHNTQ 840
            |.:|........|..:.:...|..|::...|:.||.|.  |:.. |.:||..|...|...|.:..
Human   752 AHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAIL--HLNGRLQKAEANYLRALQLKPDDVI 814

  Fly   841 GLHNL 845
            ...||
Human   815 TQSNL 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	DUF1736	323..396	CDD:369859	35/91 (38%)
		PEP_TPR_lipo	<513..871	CDD:274350	89/379 (23%)
		TPR repeat	514..542	CDD:276809	6/27 (22%)
		TPR repeat	547..591	CDD:276809	8/43 (19%)
		TPR repeat	598..625	CDD:276809	10/26 (38%)
		TPR repeat	630..660	CDD:276809	10/29 (34%)
		TPR repeat	665..693	CDD:276809	9/27 (33%)
		TPR repeat	737..764	CDD:276809	7/26 (27%)
		TPR repeat	803..834	CDD:276809	10/31 (32%)
		TPR repeat	839..867	CDD:276809	2/7 (29%)
TMTC2	NP_689801.1	DUF1736	247..318	CDD:285594	32/70 (46%)
		TPR 1	462..492		13/29 (45%)
		TPR_11	493..554	CDD:290150	24/109 (22%)
		TPR 2	493..526		14/76 (18%)
		TPR repeat	493..521	CDD:276809	12/63 (19%)
		TPR_1	493..>520	CDD:278916	11/62 (18%)
		TPR 3	527..560		13/37 (35%)
		TPR repeat	527..555	CDD:276809	11/32 (34%)
		TPR_12	557..634	CDD:290160	22/76 (29%)
		TPR repeat	560..590	CDD:276809	10/29 (34%)
		TPR 4	562..594		10/31 (32%)
		TPR repeat	595..634	CDD:276809	9/38 (24%)
		TPR 5	606..639		11/32 (34%)
		TPR_2	609..638	CDD:285020	10/28 (36%)
		TPR repeat	642..671	CDD:276809	6/28 (21%)
		TPR 6	643..676		6/32 (19%)
		TPR_11	645..708	CDD:290150	9/62 (15%)
		TPR 7	677..710		5/32 (16%)
		TPR repeat	679..705	CDD:276809	3/25 (12%)
		TPR repeat	710..774	CDD:276809	13/63 (21%)
		TPR 8	712..744		8/31 (26%)
		TPR 9	746..778		7/31 (23%)
		TPR_19	755..822	CDD:291240	17/67 (25%)
		TPR 10	779..812		11/34 (32%)
		TPR_1	779..812	CDD:278916	11/34 (32%)
		TPR repeat	779..807	CDD:276809	9/29 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820