Protein Alignment Tmtc3 and TTC16

DIOPT Version :10

• Sequence 1: NP_477246.2
• Gene: Tmtc3 / 37401
• FlyBaseID: FBgn0020312
• Length: 926
• Species: Drosophila melanogaster
• Sequence 2: NP_659402.1
• Gene: TTC16 / 158248
• HGNCID: 26536
• Length: 873
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 108/529 - (20%)
• Similarity: 182/529 - (34%)
• Gaps: 172/529 - (32%)

  Fly   276 DERTEQQSPK---LANPSGIRR--WSSSTLWKRL----SFLVGITLTLLVGRVYVMGSQ------ 325
            |:...:..||   :..|.||.:  :.:|.:::.:    ..:.|:|:.|.|...|..|.|
Human    12 DQGPSRDIPKPWVIPAPKGILQHIFGTSHVFQSICDVKPKVTGLTVPLKVREYYSRGQQCLEQAD 76

  Fly   326 ----LPIFTRFDNPASAADTPERQLTYGYLIYLNCWLLLCPSLLCCDWTMGTVPLLQGFT---DS 383
                :.:|:|       |...:.||...|.:....:|.|      ||::.....|.:.::   |:
Human    77 WETAVLLFSR-------ALHLDPQLVDFYALRAEAYLQL------CDFSSAAQNLRRAYSLQQDN 128

  Fly   384 RNITTLLTFLAL--GAMVAKTCFTRNLALSRTLIMCLGWMVLPFLPASNLFFPVGFVVAERILYM 446
            ......|||:..  |..:.:.|                    .||.|.|:|.....:..|:..:.
Human   129 CKHLERLTFVLYLQGQCLFEQC--------------------AFLDALNVFSHAAELQPEKPCFR 173

  Fly   447 PSMGYCLLVAYGFEQLQRRGSLSWQRFSQAALAILLLTHALKTHQRNLD---WRTEYSLFMSGVH 508
            .....|||.                 ..|....:.|:|:.||....|.|   :|.....|:...|
Human   174 YRCMACLLA-----------------LKQHQACLTLITNELKQDTTNADVYIFRARLYNFLQKPH 221

  Fly   509 VNQRNAKLYNNVGHALENEGKFEEALLYFQQAVRIQTDDIGAHINVGRTFNNLKRYAEAEQAYVQ 573
            :      .|.::..||....|..:|.:..|:.|                       |:|:||...
Human   222 L------CYRDLHSALLLNPKHPQARMLLQKMV-----------------------AQAQQARQD 257

  Fly   574 AKALFPQAKPGVSYHA-----RIAPNH-----------------------LNVFINLANLIAKNQ 610
            |..|..|.|   ..||     |...|:                       :..|:.:.:::.::|
Human   258 AGILAVQGK---LQHALQRINRAIENNPLDPSLFLFRGTMYRRLQEFDGAVEDFLKVLDMVTEDQ 319

  Fly   611 -------------TRLEEADHLYRQAI----------SMRSDYVQ--AYINRGDILMKLNRTAQA 650
                         |..:.|.|.|||..          ::|.:..:  .||||||...:|...|.|
Human   320 EDMVRQAQRQLLLTYNDFAVHCYRQGAYQEGVLLLNKALRDEQQEKGLYINRGDCFFQLGNLAFA 384

  Fly   651 QEVYEQALLYDNENADIYYNLGVV-----FLEQGKS--QQAQVYFNKAIELYPEHEQALL---NS 705
            :..|:|||....::......:|::     |.||.:.  |:|:.:|:.||...|:..|..|   .|
Human   385 EADYQQALALSPQDEGANTRMGLLQEKMGFCEQRRKQFQKAENHFSTAIRHNPQKAQYYLYRAKS 449

  Fly   706 AILLQELGG 714
            ..|||.:.|
Human   450 RQLLQNIFG 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	TMTC_DUF1736	323..396	CDD:462468	17/87 (20%)
		TPR	507..762	CDD:440225	59/271 (22%)
		TPR repeat	514..542	CDD:276809	6/27 (22%)
		TPR repeat	547..591	CDD:276809	10/48 (21%)
		TPR repeat	598..625	CDD:276809	8/49 (16%)
		TPR repeat	630..660	CDD:276809	13/31 (42%)
		LapB	634..896	CDD:442196	30/91 (33%)
		TPR repeat	665..693	CDD:276809	8/34 (24%)
		TPR repeat	737..764	CDD:276809
		TPR repeat	803..834	CDD:276809
		TPR repeat	839..867	CDD:276809
TTC16	NP_659402.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		1/7 (14%)
		TPR 1	61..94		7/39 (18%)
		TPR repeat	61..89	CDD:276809	7/34 (21%)
		LapB	64..359	CDD:442196	66/376 (18%)
		TPR repeat	94..124	CDD:276809	7/35 (20%)
		TPR 2	96..128		6/37 (16%)
		TPR repeat	129..164	CDD:276809	10/54 (19%)
		TPR 3	136..169		9/52 (17%)
		TPR repeat	169..199	CDD:276809	7/46 (15%)
		TPR repeat	204..231	CDD:276809	5/32 (16%)
		TPR repeat	237..280	CDD:276809	14/68 (21%)
		TPR 4	251..284		11/35 (31%)
		TPR	260..454	CDD:440225	43/196 (22%)
		TPR 5	285..318		1/32 (3%)
		TPR repeat	285..313	CDD:276809	1/27 (4%)
		TPR 6	331..364		7/32 (22%)
		TPR repeat	333..359	CDD:276809	6/25 (24%)
		TPR repeat	364..394	CDD:276809	13/29 (45%)
		TPR 7	365..398		13/32 (41%)
		TPR repeat	399..434	CDD:276809	8/34 (24%)
		TPR 8	406..439		10/32 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	553..626
		COG5099	594..>772	CDD:227430
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	639..873