DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tmtc3 and TTC16

DIOPT Version :9

Sequence 1:	NP_477246.2	Gene:	Tmtc3 / 37401	FlyBaseID:	FBgn0020312	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_659402.1	Gene:	TTC16 / 158248	HGNCID:	26536	Length:	873	Species:	Homo sapiens

Alignment Length:	529	Identity:	108/529 - (20%)
Similarity:	182/529 - (34%)	Gaps:	172/529 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 DERTEQQSPK---LANPSGIRR--WSSSTLWKRL----SFLVGITLTLLVGRVYVMGSQ------ 325
            |:...:..||   :..|.||.:  :.:|.:::.:    ..:.|:|:.|.|...|..|.|
Human    12 DQGPSRDIPKPWVIPAPKGILQHIFGTSHVFQSICDVKPKVTGLTVPLKVREYYSRGQQCLEQAD 76

  Fly   326 ----LPIFTRFDNPASAADTPERQLTYGYLIYLNCWLLLCPSLLCCDWTMGTVPLLQGFT---DS 383
                :.:|:|       |...:.||...|.:....:|.|      ||::.....|.:.::   |:
Human    77 WETAVLLFSR-------ALHLDPQLVDFYALRAEAYLQL------CDFSSAAQNLRRAYSLQQDN 128

  Fly   384 RNITTLLTFLAL--GAMVAKTCFTRNLALSRTLIMCLGWMVLPFLPASNLFFPVGFVVAERILYM 446
            ......|||:..  |..:.:.|                    .||.|.|:|.....:..|:..:.
Human   129 CKHLERLTFVLYLQGQCLFEQC--------------------AFLDALNVFSHAAELQPEKPCFR 173

  Fly   447 PSMGYCLLVAYGFEQLQRRGSLSWQRFSQAALAILLLTHALKTHQRNLD---WRTEYSLFMSGVH 508
            .....|||.                 ..|....:.|:|:.||....|.|   :|.....|:...|
Human   174 YRCMACLLA-----------------LKQHQACLTLITNELKQDTTNADVYIFRARLYNFLQKPH 221

  Fly   509 VNQRNAKLYNNVGHALENEGKFEEALLYFQQAVRIQTDDIGAHINVGRTFNNLKRYAEAEQAYVQ 573
            :      .|.::..||....|..:|.:..|:.|                       |:|:||...
Human   222 L------CYRDLHSALLLNPKHPQARMLLQKMV-----------------------AQAQQARQD 257

  Fly   574 AKALFPQAKPGVSYHA-----RIAPNH-----------------------LNVFINLANLIAKNQ 610
            |..|..|.|   ..||     |...|:                       :..|:.:.:::.::|
Human   258 AGILAVQGK---LQHALQRINRAIENNPLDPSLFLFRGTMYRRLQEFDGAVEDFLKVLDMVTEDQ 319

  Fly   611 -------------TRLEEADHLYRQAI----------SMRSDYVQ--AYINRGDILMKLNRTAQA 650
                         |..:.|.|.|||..          ::|.:..:  .||||||...:|...|.|
Human   320 EDMVRQAQRQLLLTYNDFAVHCYRQGAYQEGVLLLNKALRDEQQEKGLYINRGDCFFQLGNLAFA 384

  Fly   651 QEVYEQALLYDNENADIYYNLGVV-----FLEQGKS--QQAQVYFNKAIELYPEHEQALL---NS 705
            :..|:|||....::......:|::     |.||.:.  |:|:.:|:.||...|:..|..|   .|
Human   385 EADYQQALALSPQDEGANTRMGLLQEKMGFCEQRRKQFQKAENHFSTAIRHNPQKAQYYLYRAKS 449

  Fly   706 AILLQELGG 714
            ..|||.:.|
Human   450 RQLLQNIFG 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	DUF1736	323..396	CDD:369859	17/87 (20%)
		PEP_TPR_lipo	<513..871	CDD:274350	58/265 (22%)
		TPR repeat	514..542	CDD:276809	6/27 (22%)
		TPR repeat	547..591	CDD:276809	10/48 (21%)
		TPR repeat	598..625	CDD:276809	8/49 (16%)
		TPR repeat	630..660	CDD:276809	13/31 (42%)
		TPR repeat	665..693	CDD:276809	8/34 (24%)
		TPR repeat	737..764	CDD:276809
		TPR repeat	803..834	CDD:276809
		TPR repeat	839..867	CDD:276809
TTC16	NP_659402.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		1/7 (14%)
		TPR 1	61..94		7/39 (18%)
		TPR repeat	61..89	CDD:276809	7/34 (21%)
		TPR_11	62..124	CDD:290150	14/74 (19%)
		TPR repeat	94..124	CDD:276809	7/35 (20%)
		TPR 2	96..128		6/37 (16%)
		TPR repeat	129..164	CDD:276809	10/54 (19%)
		TPR 3	136..169		9/52 (17%)
		TPR repeat	169..199	CDD:276809	7/46 (15%)
		TPR repeat	204..231	CDD:276809	5/32 (16%)
		TPR repeat	237..280	CDD:276809	14/68 (21%)
		TPR 4	251..284		11/35 (31%)
		TPR_11	<264..314	CDD:290150	7/52 (13%)
		TPR 5	285..318		1/32 (3%)
		TPR repeat	285..313	CDD:276809	1/27 (4%)
		TPR 6	331..364		7/32 (22%)
		TPR_11	332..396	CDD:290150	20/63 (32%)
		TPR repeat	333..359	CDD:276809	6/25 (24%)
		TPR repeat	364..394	CDD:276809	13/29 (45%)
		TPR 7	365..398		13/32 (41%)
		TPR_11	367..437	CDD:290150	22/69 (32%)
		TPR_1	368..398	CDD:278916	13/29 (45%)
		TPR repeat	399..434	CDD:276809	8/34 (24%)
		TPR 8	406..439		10/32 (31%)
		TPR_11	407..471	CDD:290150	16/52 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..626
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..873
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900