DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tmtc3 and TTC32

DIOPT Version :9

Sequence 1:	NP_477246.2	Gene:	Tmtc3 / 37401	FlyBaseID:	FBgn0020312	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_001008238.1	Gene:	TTC32 / 130502	HGNCID:	32954	Length:	151	Species:	Homo sapiens

Alignment Length:	145	Identity:	40/145 - (27%)
Similarity:	60/145 - (41%)	Gaps:	16/145 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   550 AHINVGRTFNNLKRYAEAE---QAYVQ--AKALFPQAKPGVSYHARIAPNHLNVFINLANLIAKN 609
            ||.|.|       .|||||   .||::  |.|......||    ::.:|..|....|....|...
Human    17 AHFNNG-------EYAEAEALYSAYIRRCACAASSDESPG----SKCSPEDLATAYNNRGQIKYF 70

  Fly   610 QTRLEEADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEVYEQALLYDNENADIYYNLGVV 674
            :....||...|..||.::.::...|.|||.||.:|.....|.|.:::.|..:....|...:|...
Human    71 RVDFYEAMDDYTSAIEVQPNFEVPYYNRGLILYRLGYFDDALEDFKKVLDLNPGFQDATLSLKQT 135

  Fly   675 FLEQGKSQQAQVYFN 689
            .|::.:.|:..|..|
Human   136 ILDKEEKQRRNVAKN 150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	DUF1736	323..396	CDD:369859
		PEP_TPR_lipo	<513..871	CDD:274350	40/145 (28%)
		TPR repeat	514..542	CDD:276809
		TPR repeat	547..591	CDD:276809	15/45 (33%)
		TPR repeat	598..625	CDD:276809	6/26 (23%)
		TPR repeat	630..660	CDD:276809	10/29 (34%)
		TPR repeat	665..693	CDD:276809	6/25 (24%)
		TPR repeat	737..764	CDD:276809
		TPR repeat	803..834	CDD:276809
		TPR repeat	839..867	CDD:276809
TTC32	NP_001008238.1	TPR_11	2..>143	CDD:330823	37/136 (27%)
		TPR 1	8..41		12/30 (40%)
		PLN03088	<55..>123	CDD:330826	18/67 (27%)
		TPR repeat	57..87	CDD:276809	8/29 (28%)
		TPR 2	58..91		7/32 (22%)
		TPR 3	92..125		10/32 (31%)
		TPR repeat	92..120	CDD:276809	9/27 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900