Protein Alignment Tmtc3 and LOC1280064

DIOPT Version :10

• Sequence 1: NP_477246.2
• Gene: Tmtc3 / 37401
• FlyBaseID: FBgn0020312
• Length: 926
• Species: Drosophila melanogaster
• Sequence 2: XP_061518907.1
• Gene: LOC1280064 / 1280064
• VectorBaseID: AGAMI1_007711
• Length: 1154
• Species: Anopheles gambiae
• Alignment Length: 1294
• Identity: 291/1294 - (22%)
• Similarity: 409/1294 - (31%)
• Gaps: 580/1294 - (44%)

  Fly    31 QRN--LLEFLCI--CVACIVCYYNSTQCGLVFDDISAIRDNKDLRPHTPLINVFLNDFWGTPMRK 91
            |||  .::::.:  |....|.|.|:...|.|:||..||..|.|:........:..|||||||:..
Mosquito     3 QRNKSSMDYVSLGCCTLAFVLYINTLSAGFVYDDRRAILGNPDVLGTGSWSQMLHNDFWGTPLVD 67

  Fly    92 EQSHKSYRPLTVLTFRFNYLLHALEPFGYHLVNLLLHLSVCLLWRRVCRLLLRQCAASGSNAISA 156
            ..||.|||||.|.:|:.||||...:||||||||:|||.....|..::.|.||    .:|.:.::
Mosquito    68 SGSHGSYRPLCVASFKLNYLLDGFKPFGYHLVNVLLHSLATGLVVKLARHLL----PAGRSGVA- 127

  Fly   157 PSSSSVSQLNTCAFVASLLFAVHPVHTEAVTGVVGRAELLSSICFLAAFLSYAKSV-----GDSG 216
                          :|.||||.||:|||||.||||||:|...|.:|.|.|:|.:.|     ||
Mosquito   128 --------------IAGLLFAAHPIHTEAVAGVVGRADLTGCIFYLLALLAYIRHVRWRQWGD-- 176

  Fly   217 CPRRTNWLTLFGCFGSCLL--ASMLCKEQGITIAGICVVYELFV-------VHQLRPLHLCHFVL 272
               |..||.|   ..:.||  |::||||..:|...:|.:|::..       .|:.|.|
Mosquito   177 ---RRQWLAL---AATVLLAAAALLCKETAVTALVVCAIYDIIKGYAGSRDKHRARSL------- 228

  Fly   273 RLFDERTEQQSPKLANPSGIRRWSSSTLWKRLSFLVGITLTLLVGRVYVMGSQLPIFTRFDNP-A 336
                              ||...|       |:|:|...|||        .....:|:..||| |
Mosquito   229 ------------------GIIALS-------LAFIVHCRLTL--------PRPATLFSTADNPTA 260

  Fly   337 SAADTPERQLTYGYLIYLNCWLLLCPSLLCCDWTMGTVPLLQGFTDSRNITTLLTFLALGAMVAK 401
            .:.....|.||:.||..:|..|||.|.:|..||.|..:|.|....|.:.....|.:||||..:..
Mosquito   261 RSGSLWTRFLTFTYLPVVNFKLLLLPDVLSFDWGMDAIPRLGTVCDRKVALAALFYLALGWALWS 325

  Fly   402 TC------------------------FTRNLA----LSR-------------------------- 412
            :|                        |.|.||    |:|
Mosquito   326 SCRALVNRQQTPVRPSGSKTTPNASSFNRKLANKLNLARLRAGEEGSSVPSLPVVQLDDRENGDG 390

  Fly   413 ----------------------------------------------------------------- 412
                                                                             
Mosquito   391 GGGCALCKQDAGLHHTSSCRTLHNNNGLSSIMCGCGYAPEYKYLSLAAPSQLASYFCRTAGSSSS 455

  Fly   413 ----------------------------------------------------------------- 412
                                                                             
Mosquito   456 SSSSKGTVRTTTTNNNDSASINYNQSFQGAVVGKKFACHWPLGTVGDGASKEKPFPFTTLLTAPA 520

  Fly   413 -----------------------------------------------------------TLIMCL 418
                                                                       .|:|.:
Mosquito   521 DMCSPSLSSSSYTSSSSSSSSSSTSSSCASSVRGDSADGSTDEPCLPDEGSSLHNSPAAALLMSV 585

  Fly   419 GWMVLPFLPASNLFFPVGFVVAERILYMPSMGYCLLVAYG------------------------- 458
            ..:.|||||||||.|.|||||||||||:||:||||||..|
Mosquito   586 ALLALPFLPASNLLFYVGFVVAERILYLPSVGYCLLVGLGAGALIDGGGGGRSSPVSGSSISGKL 650

  Fly   459 ----------------------------------------------------------------- 458
                                                                             
Mosquito   651 SSYGRGGRRNGPPARWLGTFVRKCLSALVPPGDRSVGGAVCSDGAAVRDDASGSIHRTASDNGSG 715

  Fly   459 ----FEQLQRR--------------------GSLSWQRFSQA----------------------- 476
                :.:.||.                    ||:|.:....|
Mosquito   716 VSGRYGKFQRTNGMGAPSVSVQAVSGGGGGGGSVSGKASRPATAGRGGRAGRSTKPFGPRRRQLV 780

  Fly   477 --ALAILLLTHALKTHQRNLDWRTEYSLFMSGVHVNQRNAKLYNNVGHALENEGKFEEALLYFQQ 539
              .:.:||:.::.||.:||.||..|.|||.|.|.||.  .|...|:|..|..:|:::||
Mosquito   781 LVCVGLLLIAYSAKTVRRNRDWADEESLFRSAVAVNP--PKALGNLGSVLSAQGRYQEA------ 837

  Fly   540 AVRIQTDDIGAHINVGRTFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLAN 604
                                     .||.:|.:..:                 ||..:|..|| .
Mosquito   838 -------------------------KEALKAALNHR-----------------PNMADVHYNL-G 859

  Fly   605 LIAKNQTRLEEADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEVYEQALLYD-------- 661
            ::.:||....||...:|:||..|.....||:|.|..|:.|.|..:|..|..:....|
Mosquito   860 ILLQNQQDYNEAVESFRKAIRFRPSLALAYLNLGTSLIALGRCQEAASVLREGTKLDGAGLRDRA 924

  Fly   662 -NENADI--YYNLGVVFLEQGKSQQAQVYFNKAIELYPEH--EQALLNSAILLQELGG------- 714
             :|||.|  ...||.::.:|||.|:|...:.:|:...||.  .|.:.:      .||.
Mosquito   925 AHENARISALLQLGNLYADQGKLQRALAIYREALHTLPERYPPQGIYH------RLGDIFARLNQ 983

  Fly   715 -EEARRVSRSRLYKVLENDDQNEKVYFNLG-MLAMDESSFDEAEQFFKRAIHLKADFRSALFNLA 777
             .||.|..|:    .||....:...:.:.| |||.:.|...||||:|:||:.|..:..|...:.|
Mosquito   984 WSEAERFQRA----ALEAQPDHIAAHLSYGTMLARNSSRTSEAEQWFRRALRLAPNDASVHHHYA 1044

  Fly   778 LLLADTKRPLDAVPFLNQLIRHHPSHVKGLILLGDIY------INHMKDLD---EAEKCYRSILH 833
            ..|:..:|..:|..:          .||...|..:.|      .:.::.||   |||:.||..:.
Mosquito  1045 EFLSSQRRTEEAFQY----------RVKAAELAPEDYALVMAAASSLRLLDRKLEAERWYRQAVK 1099

  Fly   834 YDPHNTQGLHNLCVVFVERKRLAKAAACLQYAQRLAPAEDYIGRHLQIVLARLQKINKL 892
            ..|...:...||..:.....|..:||...:.|.||.|.:          |..|..:.||
Mosquito  1100 LRPQEARAHTNLGAILHLLGRTQEAANSYREALRLQPDD----------LTTLSNLAKL 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	TMTC_DUF1736	323..396	CDD:462468	25/73 (34%)
		TPR	507..762	CDD:440225	69/276 (25%)
		TPR repeat	514..542	CDD:276809	7/27 (26%)
		TPR repeat	547..591	CDD:276809	3/43 (7%)
		TPR repeat	598..625	CDD:276809	9/26 (35%)
		TPR repeat	630..660	CDD:276809	9/29 (31%)
		LapB	634..896	CDD:442196	75/290 (26%)
		TPR repeat	665..693	CDD:276809	10/29 (34%)
		TPR repeat	737..764	CDD:276809	12/27 (44%)
		TPR repeat	803..834	CDD:276809	11/39 (28%)
		TPR repeat	839..867	CDD:276809	6/27 (22%)
LOC1280064	XP_061518907.1	None