DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tmtc3 and Ifit1bl2

DIOPT Version :9

Sequence 1:	NP_477246.2	Gene:	Tmtc3 / 37401	FlyBaseID:	FBgn0020312	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_001349059.1	Gene:	Ifit1bl2 / 112419	MGIID:	2148249	Length:	466	Species:	Mus musculus

Alignment Length:	334	Identity:	73/334 - (21%)
Similarity:	142/334 - (42%)	Gaps:	59/334 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   462 LQRRGSLSWQRFSQAALAILLLTHALKTHQRNLDWRTEYSLFMSGVHVNQRNAKLYNNVGHALEN 526
            |::.||.::.|      |:.....|||....|.::...|:  ....|::..:......:..|:
Mouse   154 LRKCGSQNYTR------AMACFERALKVEPENPEYNAGYA--DVAYHLDYYDGNSLQPLKKAV-- 208

  Fly   527 EGKFEEALLYFQQAVRIQ----TDDIGAHINVG----RTFNNL--------KRYAEAEQAY-VQA 574
            ..|.|:..|....|:::|    ||:...||...    .:.||:        :|....|:|. ...
Mouse   209 SVKPEDPYLKVLLALKLQDLRKTDEAEKHIKEATLTISSQNNIFGYVAKFYRRKGCVEEALGFLK 273

  Fly   575 KALFPQAKPGVSY-HARIAPNHLNVFINLANLIAK-NQTRLEEADHL----YRQAISMRSDYVQA 633
            |||  :.||...| |.:|...|...|..:....:: |:.|.:::.||    :::.:.::..|.:|
Mouse   274 KAL--ETKPSSPYLHFQIGLCHKTQFFQMKKATSRENRKRADQSCHLAICHFKKTLELKPTYDRA 336

  Fly   634 YINRGDILMKLNRTAQAQEVYEQAL----LYDNENADIYYNLGVVFLEQGKSQQAQV-YFNKA-- 691
            ||:..::..|.::..:|::.:::.|    |.|....:|::..|.......||::|.: ::.|.
Mouse   337 YIDLAEVYAKNHQQKEAEDNFQEVLSMSNLGDYMQQEIHFRYGNFQQYYKKSEEAAITHYLKGLK 401

  Fly   692 IELYPEHEQALLNSAILLQELGGEEARRVSRSRLYKVLENDDQNEKVYFNLGMLAMDESSFDEAE 756
            ||:...:...||.:   |:||.  |.|:...     |||:       ...||::........||.
Mouse   402 IEVTSHYRDKLLKA---LEELA--EGRKEDH-----VLES-------LSLLGLVCRLRGDTSEAM 449

  Fly   757 QFFKRAIHL 765
            ..:::|:.|
Mouse   450 SCYEKALRL 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	DUF1736	323..396	CDD:369859
		PEP_TPR_lipo	<513..871	CDD:274350	62/283 (22%)
		TPR repeat	514..542	CDD:276809	5/27 (19%)
		TPR repeat	547..591	CDD:276809	14/57 (25%)
		TPR repeat	598..625	CDD:276809	5/31 (16%)
		TPR repeat	630..660	CDD:276809	7/33 (21%)
		TPR repeat	665..693	CDD:276809	6/30 (20%)
		TPR repeat	737..764	CDD:276809	5/26 (19%)
		TPR repeat	803..834	CDD:276809
		TPR repeat	839..867	CDD:276809
Ifit1bl2	NP_001349059.1	TPR_11	<63..>353	CDD:330823	45/210 (21%)
		TPR repeat	63..94	CDD:276809
		TPR repeat	99..129	CDD:276809
		TPR repeat	144..174	CDD:276809	6/25 (24%)
		TPR repeat	179..210	CDD:276809	4/34 (12%)
		TPR repeat	215..241	CDD:276809	7/25 (28%)
		TPR repeat	282..329	CDD:276809	9/46 (20%)
		TPR_11	<324..>458	CDD:330823	32/150 (21%)
		TPR repeat	334..362	CDD:276809	5/27 (19%)
		TPR repeat	372..401	CDD:276809	6/28 (21%)
		TPR repeat	429..457	CDD:276809	7/34 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900