Protein Alignment Tmtc3 and TOMM34

DIOPT Version :10

• Sequence 1: NP_477246.2
• Gene: Tmtc3 / 37401
• FlyBaseID: FBgn0020312
• Length: 926
• Species: Drosophila melanogaster
• Sequence 2: NP_006800.2
• Gene: TOMM34 / 10953
• HGNCID: 15746
• Length: 309
• Species: Homo sapiens
• Alignment Length: 341
• Identity: 72/341 - (21%)
• Similarity: 120/341 - (35%)
• Gaps: 82/341 - (24%)

  Fly   460 EQLQRRGSLSWQRFSQAALAILLLTHALKTHQRNLDWRTEYSLFMSGVHVNQRNAKLYNNVGHAL 524
            |:|:..|:.|: |..|.|.|..|...||:..|            ..|....:..:.||:|.....
Human    10 EELRAAGNESF-RNGQYAEASALYGRALRVLQ------------AQGSSDPEEESVLYSNRAACH 61

  Fly   525 ENEGKFEEALLYFQQAVRIQTDDIGAHINVGRTFNNLKRYAEAEQAYVQAKALF------PQAKP 583
            ..:|...:.:.....|:.:....|...:.....:..|::|   ..|||..|.:.      ..|..
Human    62 LKDGNCRDCIKDCTSALALVPFSIKPLLRRASAYEALEKY---PMAYVDYKTVLQIDDNVTSAVE 123

  Fly   584 GVSYHARIAPNHLN-------VFINLANLIA-KNQTRLEEADHLYRQAISMRSDYVQAYINR--- 637
            |::...|...:.|.       ..|.|..:.| |....|...:|  ::....:|....|..||
Human   124 GINRMTRALMDSLGPEWRLKLPSIPLVPVSAQKRWNSLPSENH--KEMAKSKSKETTATKNRVPS 186

  Fly   638 -GDILMKLNRTAQAQEVYEQALLYDNENADIYYNLGVVFLEQGKSQQAQVYFNKAIELYPEHEQA 701
             ||:                      |.|.:....|...:::|..:       ||||.|.|
Human   187 AGDV----------------------EKARVLKEEGNELVKKGNHK-------KAIEKYSE---- 218

  Fly   702 LLNSAILLQELGGEEARRVSRSRLYKVLENDDQNEKVYFNLGMLAMDESSFDEAEQFFKRAIHLK 766
                ::|...|  |.|...:|:..|.||:  ...|.|......|.:|..:   .:.|::||...|
Human   219 ----SLLCSNL--ESATYSNRALCYLVLK--QYTEAVKDCTEALKLDGKN---VKAFYRRAQAHK 272

  Fly   767 A--DFRSALFNLALLL 780
            |  |::|:..:::.||
Human   273 ALKDYKSSFADISNLL 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	TMTC_DUF1736	323..396	CDD:462468
		TPR	507..762	CDD:440225	51/272 (19%)
		TPR repeat	514..542	CDD:276809	5/27 (19%)
		TPR repeat	547..591	CDD:276809	9/49 (18%)
		TPR repeat	598..625	CDD:276809	6/27 (22%)
		TPR repeat	630..660	CDD:276809	5/33 (15%)
		LapB	634..896	CDD:442196	35/153 (23%)
		TPR repeat	665..693	CDD:276809	5/27 (19%)
		TPR repeat	737..764	CDD:276809	6/26 (23%)
		TPR repeat	803..834	CDD:276809
		TPR repeat	839..867	CDD:276809
TOMM34	NP_006800.2	TPR 1	9..42		12/44 (27%)
		TPR repeat	9..37	CDD:276809	10/27 (37%)
		3a0801s09	<12..>294	CDD:273380	71/339 (21%)
		TPR repeat	50..80	CDD:276809	5/29 (17%)
		TPR 2	51..84		5/32 (16%)
		TPR repeat	85..113	CDD:276809	7/30 (23%)
		TPR 3	86..118		6/34 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..189		6/29 (21%)
		TPR 4	193..226		11/49 (22%)
		TPR repeat	193..221	CDD:276809	9/42 (21%)
		TPR repeat	226..256	CDD:276809	9/31 (29%)
		TPR 5	227..260		9/34 (26%)
		TPR repeat	261..289	CDD:276809	9/28 (32%)
		TPR 6	262..294		9/27 (33%)