DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tmtc3 and Bbs4

DIOPT Version :10

Sequence 1:NP_477246.2 Gene:Tmtc3 / 37401 FlyBaseID:FBgn0020312 Length:926 Species:Drosophila melanogaster
Sequence 2:NP_780534.1 Gene:Bbs4 / 102774 MGIID:2143311 Length:520 Species:Mus musculus


Alignment Length:397 Identity:88/397 - (22%)
Similarity:162/397 - (40%) Gaps:75/397 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   527 EGKFEEALLYFQQAVRIQTDDIGAHINVGRTFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHARI 591
            ||..:|:|..||....:..........|.|:...|.::..|.:.|.:| |...|....:.::..:
Mouse    80 EGNIQESLELFQTCAVLSPQCADNLKQVARSLFLLGKHKAATEVYNEA-AKLNQKDWEICHNLGV 143

  Fly   592 APNHLNVFINLANLIAKNQTRLEEADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEVYEQ 656
            ...:|..|       .|.|.:|..|..|.:..::        ||..|.|.:......:|.|:|::
Mouse   144 CYTYLKQF-------NKAQDQLHSALQLNKHDLT--------YIMLGKIHLLQGDLDKAIEIYKK 193

  Fly   657 ALLYDNENADIYYNLGVVFLEQGKSQQAQVYFNKAIELYPEHEQALLNSAILLQELGGEEARRVS 721
            |:.:..||.::...||:::|:.|..|:|..:...|:...|.:.:|:|.:..::|..|..:   |:
Mouse   194 AVEFSPENTELLTTLGLLYLQLGVYQKAFEHLGNALTYDPANYKAILAAGSMMQTHGDFD---VA 255

  Fly   722 RSRLYKVLENDDQNEKVYFNLGMLAMDESSFDEAEQFFKRAIHLKADFRSALFNLALLLADTKRP 786
            .::...|.....::..::.|:||....:..:..|....|||.:|.......|:||.|:....::.
Mouse   256 LTKYRVVACAIPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQY 320

  Fly   787 LDAVPFLNQLIRHHPSHVKGLILLGDIY------INHMKDLDEAEKCYRSILHYDPHNTQGLHNL 845
            ..|..||:..|...|.       :|::|      :.:::|::.|.:.|                 
Mouse   321 ASAFHFLSAAINFQPK-------MGELYMLLAVALTNLEDIENARRAY----------------- 361

  Fly   846 CVVFVERKRLAKAAAC-----LQYAQRLAPAEDYIGRHLQIVLARLQKINKLPESAPERKLAY-E 904
                ||..||.|   |     |.||..|     |.....:..||:.|::        |:|:.: :
Mouse   362 ----VEAVRLDK---CNPLVNLNYAVLL-----YNQGEKKSALAQYQEM--------EKKVNFLK 406

  Fly   905 DYDPLEF 911
            |..||||
Mouse   407 DNSPLEF 413

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tmtc3NP_477246.2 TMTC_DUF1736 323..396 CDD:462468
TPR 507..762 CDD:440225 50/234 (21%)
TPR repeat 514..542 CDD:276809 6/14 (43%)
TPR repeat 547..591 CDD:276809 8/43 (19%)
TPR repeat 598..625 CDD:276809 6/26 (23%)
TPR repeat 630..660 CDD:276809 8/29 (28%)
LapB 634..896 CDD:442196 60/272 (22%)
TPR repeat 665..693 CDD:276809 7/27 (26%)
TPR repeat 737..764 CDD:276809 7/26 (27%)
TPR repeat 803..834 CDD:276809 5/36 (14%)
TPR repeat 839..867 CDD:276809 9/32 (28%)
Bbs4NP_780534.1 Required for localization to centrosomes. /evidence=ECO:0000250 1..66
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
BepA 66..201 CDD:443813 29/136 (21%)
TPR 1 67..100 6/19 (32%)
TPR repeat 68..95 CDD:276809 6/14 (43%)
Interaction with PCM1. /evidence=ECO:0000250 101..337 56/261 (21%)
TPR repeat 101..129 CDD:276809 6/28 (21%)
TPR repeat 134..164 CDD:276809 6/36 (17%)
LapB 141..398 CDD:442196 67/310 (22%)
TPR repeat 169..196 CDD:276809 8/34 (24%)
TPR repeat 202..229 CDD:276809 6/26 (23%)
TPR repeat 236..264 CDD:276809 6/30 (20%)
TPR repeat 270..298 CDD:276809 7/27 (26%)
TPR repeat 303..333 CDD:276809 8/29 (28%)
Required for localization to centrosomes. /evidence=ECO:0000250 338..520 26/113 (23%)
TPR repeat 338..366 CDD:276809 7/48 (15%)
TPR repeat 372..397 CDD:276809 7/29 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 488..520
Blue background indicates that the domain is not in the aligned region.

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